{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T17:03:57Z","timestamp":1790442237931,"version":"4.1.0"},"reference-count":41,"publisher":"SAGE Publications","issue":"11","license":[{"start":{"date-parts":[[2014,11,1]],"date-time":"2014-11-01T00:00:00Z","timestamp":1414800000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Photomedicine and Laser Surgery"],"published-print":{"date-parts":[[2014,11]]},"abstract":"<jats:p>\n                    <jats:bold>\n                      <jats:italic toggle=\"yes\">Objective:<\/jats:italic>\n                    <\/jats:bold>\n                    The purpose of this study was to assess the systemic effects of low-level laser therapy (LLLT) on thyroid gland function and, consequently, calcium regulation \u2013 as measured by serum triiodothyronine (T3), thyroxine (T4), and free calcium levels \u2013 when administered after dental implant placement in a rabbit model.\n                    <jats:bold>\n                      <jats:italic toggle=\"yes\">Background data:<\/jats:italic>\n                    <\/jats:bold>\n                    Protocols for the use of laser therapy in several clinical procedures are currently under investigation, as not all of the actions and systemic effects of laser irradiation have been clearly established.\n                    <jats:bold>\n                      <jats:italic toggle=\"yes\">Materials and methods:<\/jats:italic>\n                    <\/jats:bold>\n                    Forty male adult New Zealand rabbits were distributed across five groups of eight animals each: two control groups (C-I and C-II) of unirradiated animals, and three experimental groups (E-5, E-10, and E-20), each exposed to a distinct dose of gallium-aluminum-arsenide (GaAlAs) laser [\u03bb=830\u2009nm, 50\u2009mW, continuous wave (CW)] every 48\u2009h for a total of seven sessions. The total dose per session was 5\u2009J\/cm\n                    <jats:sup>2<\/jats:sup>\n                    in E-5, 10\u2009J\/cm\n                    <jats:sup>2<\/jats:sup>\n                    in E-10, and 20\u2009J\/cm\n                    <jats:sup>2<\/jats:sup>\n                    in E-20. Animals in C-II and all experimental groups underwent surgical extraction of the mandibular left incisor followed by immediate placement of an osseointegrated implant (Nanotite\n                    <jats:sup>\u00ae<\/jats:sup>\n                    , Biomet 3i\n                    <jats:sup>\u2122<\/jats:sup>\n                    ) into the socket. Animals in group C-I served as an absolute control for T3, T4, and calcium measurements. The level of significance was set at 5% (\n                    <jats:italic toggle=\"yes\">p<\/jats:italic>\n                    \u22640.05).\n                    <jats:bold>\n                      <jats:italic toggle=\"yes\">Results:<\/jats:italic>\n                    <\/jats:bold>\n                    ANOVA with Tukey's post-hoc test revealed significant differences in T3 and calcium levels among experimental groups, as well as significant within-group differences in T3, T4, and calcium levels over time.\n                    <jats:bold>\n                      <jats:italic toggle=\"yes\">Conclusions:<\/jats:italic>\n                    <\/jats:bold>\n                    Although not reaching abnormal values, LLLT applied to the mandible influenced thyroid function in this model.\n                  <\/jats:p>","DOI":"10.1089\/pho.2014.3756","type":"journal-article","created":{"date-parts":[[2014,9,29]],"date-time":"2014-09-29T10:17:19Z","timestamp":1411985839000},"page":"612-617","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":19,"title":["Effect of Three Different Protocols of Low-Level Laser Therapy on Thyroid Hormone Production After Dental Implant Placement in an Experimental Rabbit Model"],"prefix":"10.1177","volume":"32","author":[{"given":"Jo\u00e3o Batista Blessmann","family":"Weber","sequence":"first","affiliation":[{"name":"Pontif\u00edcia Universidade Cat\u00f3lica do Rio Grande do Sul (PUCRS)","place":["Brazil"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luciano","family":"Mayer","sequence":"additional","affiliation":[{"name":"Pontif\u00edcia Universidade Cat\u00f3lica do Rio Grande do Sul (PUCRS)","place":["Brazil"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rodrigo Alberto","family":"Cenci","sequence":"additional","affiliation":[{"name":"Pontif\u00edcia Universidade Cat\u00f3lica do Rio Grande do Sul (PUCRS)","place":["Brazil"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carlos Eduardo","family":"Baraldi","sequence":"additional","affiliation":[{"name":"Universidade Federal do Rio Grande do Sul","place":["Brazil"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Deise","family":"Ponzoni","sequence":"additional","affiliation":[{"name":"Universidade Federal do Rio Grande do Sul","place":["Brazil"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mar\u00edlia","family":"Gerhardt de Oliveira","sequence":"additional","affiliation":[{"name":"Hospital Cristo Redentor \u2013 Grupo Hospitalar Concei\u00e7\u00e3o (GHC)","place":["Brazil"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2014,11]]},"reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0025-6196(12)62034-5"},{"key":"e_1_3_2_3_2","doi-asserted-by":"crossref","first-page":"703","DOI":"10.1007\/s10103-011-0948-4","article-title":"Stability of dental implants after irradiation with an 830-nm low-level laser: a double-blind randomized clinical study","volume":"27","author":"Garcia\u2013Morales J.M.","year":"2012","unstructured":"Garcia\u2013Morales J.M., , Tortamano\u2013Neto P., , Todescan F.F., , de Andrade J.C.Jr., , Marotti J., , and Zezell D.M. 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