{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T21:18:47Z","timestamp":1777929527092,"version":"3.51.4"},"reference-count":24,"publisher":"SAGE Publications","issue":"10","license":[{"start":{"date-parts":[[2015,10,1]],"date-time":"2015-10-01T00:00:00Z","timestamp":1443657600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Photomedicine and Laser Surgery"],"published-print":{"date-parts":[[2015,10]]},"abstract":"<jats:p>\n                    <jats:bold>\n                      <jats:italic toggle=\"yes\">Objective:<\/jats:italic>\n                    <\/jats:bold>\n                    The purpose of this study was to report the application of antimicrobial photodynamic therapy (aPDT) via sinus tract associated with laser phototherapy (LPT) in conservative treatment of a late failure of endodontic retreatment in two clinical cases of post-treatment apical periodontitis.\n                    <jats:bold>\n                      <jats:italic toggle=\"yes\">Background data:<\/jats:italic>\n                    <\/jats:bold>\n                    Post-treatment apical periodontitis is a microbiological matter, because infection is present in almost all cases associated with this condition, even in teeth with apparently adequate root canal treatments. Infection is usually located within the root canal system, but in a few cases it may spread to the periradicular tissues. Many biofilms are susceptible to aPDT, particularly in dental disease. In the present two cases reports, aPDT was applied via sinus tract.\n                    <jats:bold>\n                      <jats:italic toggle=\"yes\">Methods:<\/jats:italic>\n                    <\/jats:bold>\n                    In the two clinical cases, endodontic retreatment was unsuccessful, with the presence of a persistent swelling sinus tract, despite the standard quality of the endodontic retreatment. Before any surgical intervention, a noninvasive aPDT via sinus tract was performed. The photosensitizer methylene blue (0.01%) was inserted through the entrance of the sinus tract. Laser irradiation was performed perpendicularly (660\u2009nm, 40\u2009mW, 90\u2009J\/cm\n                    <jats:sup>2<\/jats:sup>\n                    , 63\u2009sec\/point) directly over the entrance of the sinus tract. LPT (808\u2009nm, 100\u2009mW, 210\u2009J\/cm\n                    <jats:sup>2<\/jats:sup>\n                    , 59\u2009sec\/ point) was applied after each aPDT session. Seven (case 1) and 10 (case 2) successive aPDT applications were performed followed by LPT.\n                    <jats:bold>\n                      <jats:italic toggle=\"yes\">Results:<\/jats:italic>\n                    <\/jats:bold>\n                    The 18 month follow-up after treatment revealed control of the swelling sinus tract and diminishing of persistent apical periodontitis. The treatment succeeded, avoiding both surgical interventions and antimicrobial prescription.\n                    <jats:bold>\n                      <jats:italic toggle=\"yes\">Conclusions:<\/jats:italic>\n                    <\/jats:bold>\n                    The protocol of aPDT associated with LPT applied via sinus tract was revealed to be efficient for clinical infection control, and was found to be safe and conservative.\n                  <\/jats:p>","DOI":"10.1089\/pho.2015.3936","type":"journal-article","created":{"date-parts":[[2015,9,8]],"date-time":"2015-09-08T19:25:57Z","timestamp":1441740357000},"page":"524-528","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":13,"title":["Post-Treatment Apical Periodontitis Successfully Treated with Antimicrobial Photodynamic Therapy Via Sinus Tract and Laser Phototherapy: Report of Two Cases"],"prefix":"10.1177","volume":"33","author":[{"given":"Maria Stella Nunes Ara\u00fajo","family":"Moreira","sequence":"first","affiliation":[{"name":"Universidade de S\u00e3o Paulo","place":["Brazil"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jos\u00e9 Ricardo","family":"de FreitasArchilla","sequence":"additional","affiliation":[{"name":"Universidade de S\u00e3o Paulo","place":["Brazil"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cesar Angelo","family":"Lascala","sequence":"additional","affiliation":[{"name":"Universidade de S\u00e3o Paulo","place":["Brazil"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Karen M\u00fcller","family":"Ramalho","sequence":"additional","affiliation":[{"name":"Universidade de S\u00e3o Paulo","place":["Brazil"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Norbert","family":"Gutknecht","sequence":"additional","affiliation":[{"name":"University of Aachen","place":["Germany"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M\u00e1rcia Martins","family":"Marques","sequence":"additional","affiliation":[{"name":"Universidade de S\u00e3o Paulo","place":["Brazil"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2015,10]]},"reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.00531-12"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.joen.2012.12.008"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bdj.2014.200"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.joen.2006.04.007"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.1586\/14787210.2013.811861"},{"key":"e_1_3_3_7_2","article-title":"Antimicrobial photodynamic therapy: a promise candidate for caries lesions treatment","author":"Diniz IM","year":"2015","unstructured":"Diniz IM, , Horta ID, , Azevedo CS, et al. 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