{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T05:31:13Z","timestamp":1791351073325,"version":"4.3.1"},"reference-count":43,"publisher":"SAGE Publications","issue":"11","license":[{"start":{"date-parts":[[2015,11,1]],"date-time":"2015-11-01T00:00:00Z","timestamp":1446336000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Photomedicine and Laser Surgery"],"published-print":{"date-parts":[[2015,11]]},"abstract":"<jats:p>\n                    <jats:bold>\n                      <jats:italic toggle=\"yes\">Objective and background data:<\/jats:italic>\n                    <\/jats:bold>\n                    Studies suggest that intraoral low-level laser therapy (LLLT) can ameliorate oral mucositis in adult patients receiving high-dose chemotherapy. The objective of this study was to evaluate the use of a combined protocol of intraoral and extraoral LLLT in children undergoing hematopoietic stem cell transplantation (HSCT).\n                    <jats:bold>\n                      <jats:italic toggle=\"yes\">Methods:<\/jats:italic>\n                    <\/jats:bold>\n                    Twelve children undergoing HSCT were treated four times a week with a combined protocol of intraoral and extraoral LLLT, for a mean duration of 22 days. Clinical and functional mucositis scores were assessed using the National Cancer Institute Common Terminology Criteria for Adverse Events (NCI-CTCAE). These scores were compared with a matched retrospective control group of 12 children who did not receive LLLT during HSCT.\n                    <jats:bold>\n                      <jats:italic toggle=\"yes\">Results:<\/jats:italic>\n                    <\/jats:bold>\n                    Clinical mucositis scores were significantly lower in the LLLT group than in the control group (\n                    <jats:italic toggle=\"yes\">p<\/jats:italic>\n                    \u2009=\u20090.004). Incidence of ulcerative oral mucositis was also significantly lower in the LLLT group (\n                    <jats:italic toggle=\"yes\">p<\/jats:italic>\n                    \u2009=\u20090.027). Functional limitation associated with diet\/swallowing was less severe in the LLLT group; however, this was not statistically significant.\n                    <jats:bold>\n                      <jats:italic toggle=\"yes\">Conclusions:<\/jats:italic>\n                    <\/jats:bold>\n                    This study indicates that a combined protocol of intraoral and extraoral application of LLLT can reduce the severity of oral mucositis in pediatric patients undergoing HSCT. Randomized double-blind clinical trials with a larger number of subjects are needed to further test such combined protocols.\n                  <\/jats:p>","DOI":"10.1089\/pho.2015.3954","type":"journal-article","created":{"date-parts":[[2015,10,26]],"date-time":"2015-10-26T16:39:48Z","timestamp":1445877588000},"page":"540-546","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":36,"title":["Pilot Study on the Efficacy of Combined Intraoral and Extraoral Low-Level Laser Therapy for Prevention of Oral Mucositis in Pediatric Patients Undergoing Hematopoietic Stem Cell Transplantation"],"prefix":"10.1177","volume":"33","author":[{"given":"Marcos","family":"Soto","sequence":"first","affiliation":[{"name":"Universidade Federal de S\u00e3o Paulo","place":["Brazil"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rajesh V.","family":"Lalla","sequence":"additional","affiliation":[{"name":"University of Connecticut Health Center"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roseane Vasconcelos","family":"Gouveia","sequence":"additional","affiliation":[{"name":"Universidade Federal de S\u00e3o Paulo","place":["Brazil"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Victor Gattardello","family":"Zecchin","sequence":"additional","affiliation":[{"name":"Universidade Federal de S\u00e3o Paulo","place":["Brazil"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adriana","family":"Seber","sequence":"additional","affiliation":[{"name":"Universidade Federal de S\u00e3o Paulo","place":["Brazil"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nilza Nelly Fontana","family":"Lopes","sequence":"additional","affiliation":[{"name":"Universidade Federal de S\u00e3o Paulo","place":["Brazil"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2015,11]]},"reference":[{"issue":"9","key":"e_1_3_3_2_2","doi-asserted-by":"crossref","first-page":"1995","DOI":"10.1002\/cncr.20162","article-title":"Perspectives on cancer therapy-induced mucosal injury: pathogenesis, measurement, epidemiology, and consequences for patients","volume":"100","author":"Sonis ST","year":"2004","unstructured":"Sonis ST, , Elting LS, , Keefe D, et al. 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