{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T21:18:45Z","timestamp":1777929525604,"version":"3.51.4"},"reference-count":61,"publisher":"SAGE Publications","issue":"11","license":[{"start":{"date-parts":[[2016,11,1]],"date-time":"2016-11-01T00:00:00Z","timestamp":1477958400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Photomedicine and Laser Surgery"],"published-print":{"date-parts":[[2016,11]]},"abstract":"<jats:p>\n                    <jats:bold>\n                      <jats:italic toggle=\"yes\">Objective:<\/jats:italic>\n                    <\/jats:bold>\n                    The purpose of this article was to review the molecular mechanisms of low-level laser irradiation (LLLI) preconditioning for heart cell therapy.\n                    <jats:bold>\n                      <jats:italic toggle=\"yes\">Background data:<\/jats:italic>\n                    <\/jats:bold>\n                    Stem cell transplantation appears to offer a better alternative to cardiac regenerative therapy. Previous studies have confirmed that the application of LLLI plays a positive role in regulating stem cell proliferation and in remodeling the hostile milieu of infarcted myocardium. Greater understanding of LLLI's underlying mechanisms would be helpful in translating cell transplantation therapy into the clinic.\n                    <jats:bold>\n                      <jats:italic toggle=\"yes\">Methods:<\/jats:italic>\n                    <\/jats:bold>\n                    Studies investigating LLLI preconditioning for cardiac regenerative therapy published up to 2015 were retrieved from library sources and Pubmed databases.\n                    <jats:bold>\n                      <jats:italic toggle=\"yes\">Results:<\/jats:italic>\n                    <\/jats:bold>\n                    LLLI preconditioning stimulates proliferation and differentiation of stem cells through activation of cell proliferation signaling pathways and alteration of microRNA expression. It also could stimulate paracrine secretion of stem cells and alter cardiac cytokine expression in infarcted myocardium.\n                    <jats:bold>\n                      <jats:italic toggle=\"yes\">Conclusions:<\/jats:italic>\n                    <\/jats:bold>\n                    LLLI preconditioning provides a promising approach to maximize the efficacy of cardiac cell-based therapy. Although many studies have reported possible molecular mechanisms involved in LLLI preconditioning, the exact mechanisms are still not clearly understood.\n                  <\/jats:p>","DOI":"10.1089\/pho.2015.4058","type":"journal-article","created":{"date-parts":[[2016,9,14]],"date-time":"2016-09-14T12:11:10Z","timestamp":1473855070000},"page":"572-579","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":13,"title":["Low-Level Laser Irradiation Precondition for Cardiac Regenerative Therapy"],"prefix":"10.1177","volume":"34","author":[{"given":"Yiwei","family":"Liu","sequence":"first","affiliation":[{"name":"Chinese Academy of Medical Sciences and Peking Union Medical College","place":["China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hao","family":"Zhang","sequence":"additional","affiliation":[{"name":"Chinese Academy of Medical Sciences and Peking Union Medical College","place":["China"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2016,11]]},"reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1582-4934.2008.00439.x"},{"key":"e_1_3_3_3_2","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1002\/lsm.1900020209","article-title":"Transventricular revascularization by laser","volume":"2","author":"Mirhoseini M","year":"1982","unstructured":"Mirhoseini M, , Muckerheide M, , Cayton MM. Transventricular revascularization by laser. Lasers Surg Med, 1982; 2:187\u2013198.","journal-title":"Lasers Surg Med"},{"key":"e_1_3_3_4_2","doi-asserted-by":"crossref","first-page":"13542","DOI":"10.3390\/ijms140713542","article-title":"Regulation of miRNA expression by low-level laser therapy (LLLT) and photodynamic therapy (PDT)","volume":"14","author":"Kushibiki T","year":"2013","unstructured":"Kushibiki T, , Hirasawa T, , Okawa S, , Ishihara M. Regulation of miRNA expression by low-level laser therapy (LLLT) and photodynamic therapy (PDT). Int J Mol Sci, 2013; 14:13542\u201313558.","journal-title":"Int J Mol Sci"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1582-4934.2009.00886.x"},{"key":"e_1_3_3_6_2","doi-asserted-by":"crossref","first-page":"436","DOI":"10.1136\/pgmj.2004.027755","article-title":"It is time to test low level laser therapy in Great Britain","volume":"81","author":"Moshkovska T","year":"2005","unstructured":"Moshkovska T, , Mayberry J. It is time to test low level laser therapy in Great Britain. Postgrad Med J, 2005; 81:436\u2013441.","journal-title":"Postgrad Med J"},{"key":"e_1_3_3_7_2","doi-asserted-by":"publisher","DOI":"10.1002\/lsm.20383"},{"key":"e_1_3_3_8_2","doi-asserted-by":"crossref","first-page":"509","DOI":"10.1007\/s10103-011-0995-x","article-title":"Effects of low-level laser irradiation on mesenchymal stem cell proliferation: a microarray analysis","volume":"27","author":"Wu YH","year":"2012","unstructured":"Wu YH, , Wang J, , Gong DX, , Gu HY, , Hu SS, , Zhang H. Effects of low-level laser irradiation on mesenchymal stem cell proliferation: a microarray analysis. Lasers Med Sci, 2012; 27:509\u2013519.","journal-title":"Lasers Med Sci"},{"key":"e_1_3_3_9_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-051X.1996.tb00580.x"},{"key":"e_1_3_3_10_2","doi-asserted-by":"crossref","first-page":"374","DOI":"10.1002\/ar.1092350306","article-title":"Promotion of muscle regeneration in the toad (Bufo viridis) gastrocnemius muscle by low-energy laser irradiation","volume":"235","author":"Bibikova A","year":"1993","unstructured":"Bibikova A, , Oron U. Promotion of muscle regeneration in the toad (Bufo viridis) gastrocnemius muscle by low-energy laser irradiation. Anat Rec, 1993; 235:374\u2013380.","journal-title":"Anat Rec"},{"key":"e_1_3_3_11_2","doi-asserted-by":"publisher","DOI":"10.1007\/s10103-015-1730-9"},{"key":"e_1_3_3_12_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.103.2.296"},{"key":"e_1_3_3_13_2","doi-asserted-by":"publisher","DOI":"10.1002\/lsm.20709"},{"key":"e_1_3_3_14_2","doi-asserted-by":"publisher","DOI":"10.1002\/lsm.20492"},{"key":"e_1_3_3_15_2","doi-asserted-by":"publisher","DOI":"10.1067\/mtc.2000.110250"},{"key":"e_1_3_3_16_2","doi-asserted-by":"crossref","first-page":"376","DOI":"10.1196\/annals.1341.033","article-title":"Stem cells for cardiomyocyte regeneration: state of the art","volume":"1047","author":"Peschle C","year":"2005","unstructured":"Peschle C, , Condorelli G. Stem cells for cardiomyocyte regeneration: state of the art. Ann N Y Acad Sci, 2005; 1047:376\u2013385.","journal-title":"Ann N Y Acad Sci"},{"key":"e_1_3_3_17_2","doi-asserted-by":"publisher","DOI":"10.1080\/07853890500422982"},{"key":"e_1_3_3_18_2","doi-asserted-by":"publisher","DOI":"10.1007\/s10103-011-0885-2"},{"key":"e_1_3_3_19_2","doi-asserted-by":"publisher","DOI":"10.1007\/s10103-005-0355-9"},{"key":"e_1_3_3_20_2","doi-asserted-by":"publisher","DOI":"10.1186\/1423-0127-16-4"},{"key":"e_1_3_3_21_2","doi-asserted-by":"publisher","DOI":"10.1002\/lsm.20759"},{"key":"e_1_3_3_22_2","doi-asserted-by":"crossref","first-page":"423","DOI":"10.1007\/s10103-011-0930-1","article-title":"The effects of low-level laser irradiation on differentiation and proliferation of human bone marrow mesenchymal stem cells into neurons and osteoblasts\u2014an in vitro study","volume":"27","author":"Soleimani M","year":"2012","unstructured":"Soleimani M, , Abbasnia E, , Fathi M, , Sahraei H, , Fathi Y, , Kaka G. The effects of low-level laser irradiation on differentiation and proliferation of human bone marrow mesenchymal stem cells into neurons and osteoblasts\u2014an in vitro study. Lasers Med Sci, 2012; 27:423\u2013430.","journal-title":"Lasers Med Sci"},{"issue":"1","key":"e_1_3_3_23_2","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1111\/ocr.12081","article-title":"Visible red and infrared light alters gene expression in human marrow stromal fibroblast cells","volume":"18","author":"Guo J","year":"2015","unstructured":"Guo J, , Wang Q, , Wai D, et al. Visible red and infrared light alters gene expression in human marrow stromal fibroblast cells. Orthod Craniofac Res, 2015; 18 Suppl 1:50\u201361.","journal-title":"Orthod Craniofac Res"},{"key":"e_1_3_3_24_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2007.06.009"},{"key":"e_1_3_3_25_2","doi-asserted-by":"crossref","first-page":"1746","DOI":"10.1096\/fj.10-178053","article-title":"Modification of Akt1 by methylglyoxal promotes the proliferation of vascular smooth muscle cells","volume":"25","author":"Chang T","year":"2011","unstructured":"Chang T, , Wang R, , Olson DJ, , Mousseau DD, , Ross AR, , Wu L. Modification of Akt1 by methylglyoxal promotes the proliferation of vascular smooth muscle cells. FASEB J, 2011; 25:1746\u20131757.","journal-title":"FASEB J"},{"key":"e_1_3_3_26_2","doi-asserted-by":"publisher","DOI":"10.1291\/hypres.27.887"},{"key":"e_1_3_3_27_2","doi-asserted-by":"crossref","first-page":"588","DOI":"10.1038\/emm.2005.72","article-title":"Prostaglandin E2 stimulates angiogenesis by activating the nitric oxide\/cGMP pathway in human umbilical vein endothelial cells","volume":"37","author":"Namkoong S","year":"2005","unstructured":"Namkoong S, , Lee SJ, , Kim CK, et al. Prostaglandin E2 stimulates angiogenesis by activating the nitric oxide\/cGMP pathway in human umbilical vein endothelial cells. Exp Mol Med, 2005; 37:588\u2013600.","journal-title":"Exp Mol Med"},{"key":"e_1_3_3_28_2","doi-asserted-by":"crossref","first-page":"172","DOI":"10.1002\/jcp.24119","article-title":"Photoactivation of bone marrow mesenchymal stromal cells with diode laser: effects and mechanisms of action","volume":"228","author":"Giannelli M","year":"2013","unstructured":"Giannelli M, , Chellini F, , Sassoli C, et al. Photoactivation of bone marrow mesenchymal stromal cells with diode laser: effects and mechanisms of action. J Cell Physiol, 2013; 228:172\u2013181.","journal-title":"J Cell Physiol"},{"key":"e_1_3_3_29_2","doi-asserted-by":"publisher","DOI":"10.2174\/138945012799499749"},{"key":"e_1_3_3_30_2","doi-asserted-by":"publisher","DOI":"10.1007\/s13105-010-0050-6"},{"key":"e_1_3_3_31_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrm2621"},{"key":"e_1_3_3_32_2","doi-asserted-by":"publisher","DOI":"10.1089\/scd.2011.0695"},{"key":"e_1_3_3_33_2","doi-asserted-by":"publisher","DOI":"10.1002\/jcp.20843"},{"key":"e_1_3_3_34_2","doi-asserted-by":"publisher","DOI":"10.1002\/term.1483"},{"issue":"1","key":"e_1_3_3_35_2","first-page":"II253","article-title":"Mesenchymal progenitor cells differentiate into an endothelial phenotype, enhance vascular density, and improve heart function in a rat cellular cardiomyoplasty model","volume":"108","author":"Davani S","year":"2003","unstructured":"Davani S, , Marandin A, , Mersin N, et al. Mesenchymal progenitor cells differentiate into an endothelial phenotype, enhance vascular density, and improve heart function in a rat cellular cardiomyoplasty model. Circulation, 2003; 108 Suppl 1:II253\u2013II258.","journal-title":"Circulation"},{"key":"e_1_3_3_36_2","first-page":"150","article-title":"Insulin-like growth factor 1 induces bone mesenchymal stem cells differentiation into cardiomyocyte-like cells","volume":"41","author":"Wang XL","year":"2013","unstructured":"Wang XL, , Li CM, , Lu Q, , Wang L, , Wang J, , Gong HB. Insulin-like growth factor 1 induces bone mesenchymal stem cells differentiation into cardiomyocyte-like cells. Zhonghua Xin Xue Guan Bing Za Zhi, 2013; 41:150\u2013155.","journal-title":"Zhonghua Xin Xue Guan Bing Za Zhi"},{"key":"e_1_3_3_37_2","doi-asserted-by":"crossref","first-page":"336","DOI":"10.1097\/00029330-200802020-00011","article-title":"Hepatocyte growth factor combined with insulin like growth factor-1 improves expression of GATA-4 in mesenchymal stem cells cocultured with cardiomyocytes","volume":"121","author":"Li Z","year":"2008","unstructured":"Li Z, , Gu TX, , Zhang YH. Hepatocyte growth factor combined with insulin like growth factor-1 improves expression of GATA-4 in mesenchymal stem cells cocultured with cardiomyocytes. Chin Med J (Engl), 2008; 121:336\u2013340.","journal-title":"Chin Med J (Engl)"},{"key":"e_1_3_3_38_2","doi-asserted-by":"publisher","DOI":"10.1038\/nm0405-367"},{"key":"e_1_3_3_39_2","doi-asserted-by":"publisher","DOI":"10.1096\/fj.05-5211com"},{"key":"e_1_3_3_40_2","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.200608093"},{"key":"e_1_3_3_41_2","doi-asserted-by":"publisher","DOI":"10.1902\/jop.1992.63.12.960"},{"key":"e_1_3_3_42_2","doi-asserted-by":"publisher","DOI":"10.1006\/dbio.1998.9094"},{"key":"e_1_3_3_43_2","doi-asserted-by":"publisher","DOI":"10.1096\/fj.02-0072com"},{"key":"e_1_3_3_44_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2007.12.095"},{"key":"e_1_3_3_45_2","doi-asserted-by":"publisher","DOI":"10.1093\/cvr\/cvm025"},{"key":"e_1_3_3_46_2","doi-asserted-by":"publisher","DOI":"10.1089\/scd.2008.0352"},{"key":"e_1_3_3_47_2","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1016\/j.jphotobiol.2007.08.005","article-title":"Anti-inflammatory effects of low-level laser therapy (LLLT) with two different red wavelengths (660\u2009nm and 684\u2009nm) in carrageenan-induced rat paw edema","volume":"89","author":"Albertini R","year":"2007","unstructured":"Albertini R, , Villaverde AB, , Aimbire F, et al. Anti-inflammatory effects of low-level laser therapy (LLLT) with two different red wavelengths (660\u2009nm and 684\u2009nm) in carrageenan-induced rat paw edema. J Photochem Photobiol B, 2007; 89:50\u201355.","journal-title":"J Photochem Photobiol B"},{"key":"e_1_3_3_48_2","doi-asserted-by":"publisher","DOI":"10.1002\/lsm.20658"},{"key":"e_1_3_3_49_2","doi-asserted-by":"publisher","DOI":"10.1007\/s10103-007-0491-5"},{"key":"e_1_3_3_50_2","doi-asserted-by":"publisher","DOI":"10.1089\/pho.2008.2420"},{"key":"e_1_3_3_51_2","doi-asserted-by":"publisher","DOI":"10.1089\/pho.2010.2866"},{"key":"e_1_3_3_52_2","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1016\/j.ijcard.2006.06.014","article-title":"Effects of GM-CSF on the stem cells mobilization and plasma C-reactive protein levels in patients with acute myocardial infarction","volume":"113","author":"Deng Z","year":"2006","unstructured":"Deng Z, , Yang C, , Deng H, et al. Effects of GM-CSF on the stem cells mobilization and plasma C-reactive protein levels in patients with acute myocardial infarction. Int J Cardiol, 2006; 113:92\u201396.","journal-title":"Int J Cardiol"},{"key":"e_1_3_3_53_2","doi-asserted-by":"publisher","DOI":"10.1161\/hc4201.097835"},{"key":"e_1_3_3_54_2","doi-asserted-by":"publisher","DOI":"10.1038\/33340"},{"key":"e_1_3_3_55_2","first-page":"35","article-title":"Effect of light emitting diode irradiation on proliferation of human bone marrow mesenchymal stem cells","volume":"26","author":"Li WT","year":"2006","unstructured":"Li WT, , Chen HL, , Wang CT. Effect of light emitting diode irradiation on proliferation of human bone marrow mesenchymal stem cells. J Med Biol Eng, 2006; 26:35\u201342.","journal-title":"J Med Biol Eng"},{"key":"e_1_3_3_56_2","doi-asserted-by":"publisher","DOI":"10.1007\/s10103-007-0479-1"},{"key":"e_1_3_3_57_2","doi-asserted-by":"publisher","DOI":"10.1007\/s10103-008-0550-6"},{"key":"e_1_3_3_58_2","doi-asserted-by":"crossref","first-page":"463","DOI":"10.1002\/lsm.20791","article-title":"In vitro effect of carboplatin, cytarabine, paclitaxel, vincristine, and low-power laser irradiation on murine mesenchymal stem cells","volume":"41","author":"Horvat-Karajz K","year":"2009","unstructured":"Horvat-Karajz K, , Balogh Z, , Kovacs V, , Drrernat AH, , Sreter L, , Uher F. In vitro effect of carboplatin, cytarabine, paclitaxel, vincristine, and low-power laser irradiation on murine mesenchymal stem cells. Lasers Surg Med, 2009; 41:463\u2013469.","journal-title":"Lasers Surg Med"},{"key":"e_1_3_3_59_2","doi-asserted-by":"publisher","DOI":"10.1089\/pho.2009.2540"},{"key":"e_1_3_3_60_2","article-title":"Low-power GaAlAs laser irradiation promotes the proliferation and osteogenic differentiation of stem cells via IGF1 and BMP2","volume":"7","author":"Wu JY","year":"2012","unstructured":"Wu JY, , Wang YH, , Wang GJ, et al. Low-power GaAlAs laser irradiation promotes the proliferation and osteogenic differentiation of stem cells via IGF1 and BMP2. PLoS One, 2012; 7:e44027.","journal-title":"PLoS One"},{"key":"e_1_3_3_61_2","doi-asserted-by":"crossref","first-page":"645","DOI":"10.1007\/s10103-011-1005-z","article-title":"The effect of noncoherent red light irradiation on proliferation and osteogenic differentiation of bone marrow mesenchymal stem cells","volume":"27","author":"Peng F","year":"2012","unstructured":"Peng F, , Wu H, , Zheng Y, , Xu X, , Yu J. The effect of noncoherent red light irradiation on proliferation and osteogenic differentiation of bone marrow mesenchymal stem cells. Lasers Med Sci, 2012; 27:645\u2013653.","journal-title":"Lasers Med Sci"},{"key":"e_1_3_3_62_2","doi-asserted-by":"publisher","DOI":"10.1007\/s10103-012-1067-6"}],"container-title":["Photomedicine and Laser Surgery"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1089\/pho.2015.4058","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1089\/pho.2015.4058","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1089\/pho.2015.4058","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T23:40:37Z","timestamp":1777678837000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/full\/10.1089\/pho.2015.4058"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,11]]},"references-count":61,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2016,11]]}},"alternative-id":["10.1089\/pho.2015.4058"],"URL":"https:\/\/doi.org\/10.1089\/pho.2015.4058","relation":{},"ISSN":["1549-5418","1557-8550"],"issn-type":[{"value":"1549-5418","type":"print"},{"value":"1557-8550","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,11]]}}}