{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,29]],"date-time":"2026-10-29T21:55:53Z","timestamp":1793310953781,"version":"4.5.0"},"reference-count":27,"publisher":"SAGE Publications","issue":"8","license":[{"start":{"date-parts":[[2016,8,1]],"date-time":"2016-08-01T00:00:00Z","timestamp":1470009600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Photomedicine and Laser Surgery"],"published-print":{"date-parts":[[2016,8]]},"abstract":"<jats:p>\n                    <jats:bold>\n                      <jats:italic toggle=\"yes\">Objective:<\/jats:italic>\n                    <\/jats:bold>\n                    The present study aimed to assess the impact of low-level laser (LLL) on low salivary flow rate in patients undergoing radiochemotherapy (RT-CT) for head and neck cancer.\n                    <jats:bold>\n                      <jats:italic toggle=\"yes\">Background data:<\/jats:italic>\n                    <\/jats:bold>\n                    LLL has shown efficiency in preventing hyposalivation in patients under different pathological conditions, including those undergoing RT-CT.\n                    <jats:bold>\n                      <jats:italic toggle=\"yes\">Methods:<\/jats:italic>\n                    <\/jats:bold>\n                    During all RT-CT, 17 patients received laser therapy and 10 received clinical care only. An Indium-Gallium-Aluminum-Phosphorus diode laser was punctually used for intraoral (660\u2009nm, 40 mW, 10\u2009J\/cm\n                    <jats:sup>2<\/jats:sup>\n                    , illuminated area 0.04\u2009cm\n                    <jats:sup>2<\/jats:sup>\n                    , 10\u2009sec) and extraoral irradiation (780\u2009nm, 15 mW, 3.8\u2009J\/cm\n                    <jats:sup>2<\/jats:sup>\n                    , illuminated area 0.04\u2009cm\n                    <jats:sup>2<\/jats:sup>\n                    , 10\u2009sec), three times a week and on alternate days, for a total of 21 sessions. Unstimulated salivary flow rate was assessed before the first RT session (N0), at the 15th RT session (N15), at the last RT session (Nf), and at 30 (N30) and 90 days after the end of the oncologic treatment (N90).\n                    <jats:bold>\n                      <jats:italic toggle=\"yes\">Results:<\/jats:italic>\n                    <\/jats:bold>\n                    At N15, Nf, and N30, patients treated with LLL showed significantly higher averages of salivary flow rate when compared with patients receiving clinical care only.\n                    <jats:bold>\n                      <jats:italic toggle=\"yes\">Conclusions:<\/jats:italic>\n                    <\/jats:bold>\n                    LLL seems to be an efficient tool for mitigation of salivary hypofunction in patients undergoing RT for head and neck cancer.\n                  <\/jats:p>","DOI":"10.1089\/pho.2016.4104","type":"journal-article","created":{"date-parts":[[2016,5,20]],"date-time":"2016-05-20T02:57:51Z","timestamp":1463713071000},"page":"326-330","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":39,"title":["Low-Level Laser for Mitigation of Low Salivary Flow Rate in Head and Neck Cancer Patients Undergoing Radiochemotherapy: A Prospective Longitudinal Study"],"prefix":"10.1177","volume":"34","author":[{"given":"Fernanda Aurora Stabile","family":"Gonnelli","sequence":"first","affiliation":[{"name":"Universidade Federal de S\u00e3o Paulo\/Escola Paulista de Medicina\/Hospital S\u00e3o Paulo \u2013 UNIFESP\/EPM\/HSP","place":["Brazil"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luiz Felipe","family":"Palma","sequence":"additional","affiliation":[{"name":"Universidade Federal de S\u00e3o Paulo\/Escola Paulista de Medicina\/Hospital S\u00e3o Paulo \u2013 UNIFESP\/EPM\/HSP","place":["Brazil"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adelmo Jos\u00e9","family":"Giordani","sequence":"additional","affiliation":[{"name":"Universidade Federal de S\u00e3o Paulo\/Escola Paulista de Medicina\/Hospital S\u00e3o Paulo \u2013 UNIFESP\/EPM\/HSP","place":["Brazil"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aline Lima Silva","family":"Deboni","sequence":"additional","affiliation":[{"name":"Universidade Federal de S\u00e3o Paulo\/Escola Paulista de Medicina\/Hospital S\u00e3o Paulo \u2013 UNIFESP\/EPM\/HSP","place":["Brazil"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rodrigo Souza","family":"Dias","sequence":"additional","affiliation":[{"name":"Universidade Federal de S\u00e3o Paulo\/Escola Paulista de Medicina\/Hospital S\u00e3o Paulo \u2013 UNIFESP\/EPM\/HSP","place":["Brazil"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roberto Ara\u00fajo","family":"Segreto","sequence":"additional","affiliation":[{"name":"Universidade Federal de S\u00e3o Paulo\/Escola Paulista de Medicina\/Hospital S\u00e3o Paulo \u2013 UNIFESP\/EPM\/HSP","place":["Brazil"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Helena Regina Comodo","family":"Segreto","sequence":"additional","affiliation":[{"name":"Universidade Federal de S\u00e3o Paulo\/Escola Paulista de Medicina\/Hospital S\u00e3o Paulo \u2013 UNIFESP\/EPM\/HSP","place":["Brazil"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2016,8]]},"reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijrobp.2007.04.021"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0360-3016(01)01717-5"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1590\/S1806-83242007000300014"},{"key":"e_1_3_2_5_2","doi-asserted-by":"crossref","first-page":"393","DOI":"10.1259\/bjr\/66754762","article-title":"Assessment of post-radiotherapy salivary glands","volume":"1001","author":"Cheng SC","year":"2011","unstructured":"Cheng SC, , Wu VW, , Kwong DL, , Ying MT. 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