{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,15]],"date-time":"2026-06-15T21:54:54Z","timestamp":1781560494271,"version":"3.54.5"},"reference-count":20,"publisher":"SAGE Publications","issue":"3","license":[{"start":{"date-parts":[[2016,12,30]],"date-time":"2016-12-30T00:00:00Z","timestamp":1483056000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Photomedicine and Laser Surgery"],"published-print":{"date-parts":[[2017,3]]},"abstract":"<jats:p>\n                    <jats:bold>\n                      <jats:italic toggle=\"yes\">Background:<\/jats:italic>\n                    <\/jats:bold>\n                    The CO\n                    <jats:sub>2<\/jats:sub>\n                    laser has become the gold standard treatment in dermatologic surgery for the treatment of a large number of skin and mucosal lesions. The introduction of the fractional micro-ablative technology represented an integration to the ablative resurfacing technique, reducing the healing time and the side effects.\n                    <jats:bold>\n                      <jats:italic toggle=\"yes\">Objective:<\/jats:italic>\n                    <\/jats:bold>\n                    Vaginal rejuvenation performed with this technique is a minimally invasive procedure that stimulates internal tissues of the female lower genital tract to regenerate the mucosa, improving tissue trophism and restoring the correct functionality.\n                    <jats:bold>\n                      <jats:italic toggle=\"yes\">Methods:<\/jats:italic>\n                    <\/jats:bold>\n                    In our experience, 386 menopausal women affected with vulvo-vaginal atrophy (VVA) were treated with three section of fractional micro-ablative CO\n                    <jats:sub>2<\/jats:sub>\n                    laser.\n                    <jats:bold>\n                      <jats:italic toggle=\"yes\">Results:<\/jats:italic>\n                    <\/jats:bold>\n                    After three treatments, patients reported a complete improvement of the symptoms (59.94% dryness, 56.26% burn, sensation, 48.75% dyspareunia, 56.37% itch, 73.15% soreness, and 48.79% vaginal introitus pain).\n                    <jats:bold>\n                      <jats:italic toggle=\"yes\">Conclusions:<\/jats:italic>\n                    <\/jats:bold>\n                    Fractional micro-ablative CO\n                    <jats:sub>2<\/jats:sub>\n                    laser seems to reduce symptoms related to vaginal atrophy. The beneficial effects were reported just after the first session and confirmed 12 months after the last session.\n                  <\/jats:p>","DOI":"10.1089\/pho.2016.4173","type":"journal-article","created":{"date-parts":[[2017,1,5]],"date-time":"2017-01-05T17:40:07Z","timestamp":1483638007000},"page":"171-175","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":68,"title":["Fractional CO\n                    <sub>2<\/sub>\n                    Laser: From Skin Rejuvenation to Vulvo-Vaginal Reshaping"],"prefix":"10.1177","volume":"35","author":[{"given":"Maurizio","family":"Filippini","sequence":"first","affiliation":[{"name":"Hospital State of Republic of San Marino"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ester","family":"Del Duca","sequence":"additional","affiliation":[{"name":"University of Rome Tor Vergata","place":["Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francesca","family":"Negosanti","sequence":"additional","affiliation":[{"name":"Dermatology Center srl","place":["Italy"]},{"name":"\u201d University of Rome Tor Vergata","place":["Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Diletta","family":"Bonciani","sequence":"additional","affiliation":[{"name":"University of Florence","place":["Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luca","family":"Negosanti","sequence":"additional","affiliation":[{"name":"S.Orsola-Malpighi University Hospital Bologna","place":["Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mario","family":"Sannino","sequence":"additional","affiliation":[{"name":"\u201d University of Rome Tor Vergata","place":["Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giovanni","family":"Cannarozzo","sequence":"additional","affiliation":[{"name":"\u201d University of Rome Tor Vergata","place":["Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Steven Paul","family":"Nistic\u00f2","sequence":"additional","affiliation":[{"name":"\u201d University of Rome Tor Vergata","place":["Italy"]},{"name":"\u201cMagna Grecia\u201d University of Catanzaro","place":["Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2016,12,30]]},"reference":[{"key":"e_1_3_2_2_2","unstructured":"Campolmi P Bonan P Cannarozzo G. 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Am J Clin Dermatol, 2013; 14:27\u201347.","journal-title":"Am J Clin Dermatol"},{"key":"e_1_3_2_14_2","doi-asserted-by":"publisher","DOI":"10.1177\/074880681102800309"},{"key":"e_1_3_2_15_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.maturitas.2014.12.006"},{"key":"e_1_3_2_16_2","doi-asserted-by":"publisher","DOI":"10.3109\/13697137.2014.975197"},{"key":"e_1_3_2_17_2","doi-asserted-by":"crossref","first-page":"504","DOI":"10.1097\/GCO.0000000000000230","article-title":"The use of pulsed CO2 lasers for the treatment of vulvovaginal atrophy","volume":"27","author":"Stefano S","year":"2015","unstructured":"Stefano S, , Stavros A, , Massimo C. The use of pulsed CO2 lasers for the treatment of vulvovaginal atrophy. 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