{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T21:20:01Z","timestamp":1777929601301,"version":"3.51.4"},"reference-count":21,"publisher":"SAGE Publications","issue":"1","license":[{"start":{"date-parts":[[2018,1,1]],"date-time":"2018-01-01T00:00:00Z","timestamp":1514764800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Photomedicine and Laser Surgery"],"published-print":{"date-parts":[[2018,1]]},"abstract":"<jats:p>\n                    <jats:bold>\n                      <jats:italic toggle=\"yes\">Background:<\/jats:italic>\n                    <\/jats:bold>\n                    Retinal capillary hemangioma (RCH) is a rare and refractory eye tumor.\n                    <jats:bold>\n                      <jats:italic toggle=\"yes\">Objective:<\/jats:italic>\n                    <\/jats:bold>\n                    The aim of this study was to investigate the therapeutic efficacy of two laser-based therapies for RCH, photodynamic therapy (PDT), and focal photocoagulation-based treatment.\n                    <jats:bold>\n                      <jats:italic toggle=\"yes\">Materials and methods:<\/jats:italic>\n                    <\/jats:bold>\n                    This was a retrospective study. Eight RCH patients (10 eyes) receiving laser treatment and followed up from November 2011 to December 2016 in our hospital were selected and their medical records reviewed. Clinical results and correlations between various clinicodemographic factors and vision outcome were analyzed.\n                    <jats:bold>\n                      <jats:italic toggle=\"yes\">Results:<\/jats:italic>\n                    <\/jats:bold>\n                    A total of 39 RCH tumor bodies were found and treated. Eleven sessions of PDT and 25 sessions of photocoagulation were administered. Other treatments included five intravitreal injections of antivascular endothelial growth factor or triamcinolone acetonide and one vitreoretinal surgery. After the follow-up period of 54.3\u2009\u00b1\u200929.8 months, 35 tumor bodies were stable or regressed, and 4 were recurrent. Vision was improved in four eyes, stable in one, and reduced in five relative to baseline. Photocoagulation was more likely to induce tumor bleeding than PDT (4 eyes vs. 1) and to increase subretinal fluid (3 eyes vs. 1). In correlation analysis, subretinal fluid accumulation was predictive of poor vision outcome (\n                    <jats:italic toggle=\"yes\">r<\/jats:italic>\n                    \u2009=\u20090.69,\n                    <jats:italic toggle=\"yes\">p<\/jats:italic>\n                    \u2009=\u20090.03).\n                    <jats:bold>\n                      <jats:italic toggle=\"yes\">Conclusions:<\/jats:italic>\n                    <\/jats:bold>\n                    Photodynamic- and photocoagulation-based therapies are both reasonably effective against most RCH tumor bodies, but PDT carries lower risks of bleeding and subretinal fluid refraction. Formation of subretinal fluid may predict poor vision outcome in RCH.\n                  <\/jats:p>","DOI":"10.1089\/pho.2017.4296","type":"journal-article","created":{"date-parts":[[2017,10,25]],"date-time":"2017-10-25T14:25:43Z","timestamp":1508941543000},"page":"10-17","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":13,"title":["Long-Term Therapeutic Outcomes of Photodynamic Therapy-Based or Photocoagulation-Based Treatments on Retinal Capillary Hemangioma"],"prefix":"10.1177","volume":"36","author":[{"given":"Chuangxin","family":"Huang","sequence":"first","affiliation":[{"name":"Sun Yat-sen University","place":["China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhen","family":"Tian","sequence":"additional","affiliation":[{"name":"Sun Yat-sen University","place":["China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kunbei","family":"Lai","sequence":"additional","affiliation":[{"name":"Sun Yat-sen University","place":["China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaojin","family":"Zhong","sequence":"additional","affiliation":[{"name":"Sun Yat-sen University","place":["China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lijun","family":"Zhou","sequence":"additional","affiliation":[{"name":"Sun Yat-sen University","place":["China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fabao","family":"Xu","sequence":"additional","affiliation":[{"name":"Sun Yat-sen University","place":["China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Huasheng","family":"Yang","sequence":"additional","affiliation":[{"name":"Sun Yat-sen University","place":["China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lin","family":"Lu","sequence":"additional","affiliation":[{"name":"Sun Yat-sen University","place":["China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chenjin","family":"Jin","sequence":"additional","affiliation":[{"name":"Sun Yat-sen University","place":["China"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2018,1]]},"reference":[{"key":"e_1_3_3_2_2","first-page":"OP446","article-title":"Fifteen year review of treated cases of retinal angiomatosis","volume":"83","author":"Annesley WH","year":"1977","unstructured":"Annesley WHJr, , Leonard BC, , Shields JA, , Tasman WS. Fifteen year review of treated cases of retinal angiomatosis. Trans Sect Ophthalmol Am Acad Ophthalmol Otolaryngol, 1977; 83:OP446\u2013OP453.","journal-title":"Trans Sect Ophthalmol Am Acad Ophthalmol Otolaryngol"},{"key":"e_1_3_3_3_2","doi-asserted-by":"crossref","first-page":"663","DOI":"10.1056\/NEJMicm0912768","article-title":"Images in clinical medicine. Retinal hemangioblastoma in von Hippel\u2013Lindau disease","volume":"363","author":"Bastos-Carvalho A","year":"2010","unstructured":"Bastos-Carvalho A, , Damato B. Images in clinical medicine. Retinal hemangioblastoma in von Hippel\u2013Lindau disease. N Engl J Med, 2010; 363:663.","journal-title":"N Engl J Med"},{"key":"e_1_3_3_4_2","doi-asserted-by":"crossref","first-page":"2479","DOI":"10.1097\/IAE.0000000000000254","article-title":"Therapeutic outcomes of retinal hemangioblastomas","volume":"34","author":"Kim H","year":"2014","unstructured":"Kim H, , Yi JH, , Kwon HJ, , Lee CS, , Lee SC. Therapeutic outcomes of retinal hemangioblastomas. Retina, 2014; 34:2479\u20132486.","journal-title":"Retina"},{"key":"e_1_3_3_5_2","doi-asserted-by":"crossref","first-page":"442","DOI":"10.1016\/j.optm.2005.06.011","article-title":"Juxtapapillary hemangioma: a case report and review of clinical features and management of von Hippel\u2013Lindau disease","volume":"76","author":"Aumiller MS.","year":"2005","unstructured":"Aumiller MS. Juxtapapillary hemangioma: a case report and review of clinical features and management of von Hippel\u2013Lindau disease. Optometry, 2005; 76:442\u2013449.","journal-title":"Optometry"},{"key":"e_1_3_3_6_2","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1159\/000335954","article-title":"A large retinal capillary hemangioma in the anterior retina treated with photodynamic therapy","volume":"3","author":"Cheung J","year":"2012","unstructured":"Cheung J, , Lee GK, , Tham CC. 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