{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,11]],"date-time":"2026-09-11T02:56:31Z","timestamp":1789095391915,"version":"build-2803163510"},"reference-count":33,"publisher":"SAGE Publications","issue":"1","license":[{"start":{"date-parts":[[2018,1,1]],"date-time":"2018-01-01T00:00:00Z","timestamp":1514764800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Photomedicine and Laser Surgery"],"published-print":{"date-parts":[[2018,1]]},"abstract":"<jats:p>\n                    <jats:bold>\n                      <jats:italic toggle=\"yes\">Background:<\/jats:italic>\n                    <\/jats:bold>\n                    Diabetes Mellitus is a chronic disease that can lead to lower-limb ulceration. The photodynamic therapy (PDT) is based on light interaction with a photosensitizer capable to promote bacterial death and acceleration of wound healing.\n                    <jats:bold>\n                      <jats:italic toggle=\"yes\">Objective:<\/jats:italic>\n                    <\/jats:bold>\n                    This study aims to accomplish a macroscopic morphometry evaluation on diabetic ulcer area in humans that were under PDT.\n                    <jats:bold>\n                      <jats:italic toggle=\"yes\">Materials and methods:<\/jats:italic>\n                    <\/jats:bold>\n                    A clinical study was conducted by convenience sample, experimental, controlled, and blinded, composed of 12 patients of both sexes with diabetic ulcers in lower limbs that were divided into two groups, control (\n                    <jats:italic toggle=\"yes\">n<\/jats:italic>\n                    \u2009=\u20096) and PDT (\n                    <jats:italic toggle=\"yes\">n<\/jats:italic>\n                    \u2009=\u20096). They were all treated with collagenase\/chloramphenicol during the experimental period, in which six of them had received PDT with Methylene Blue dye (0.01%) associated with laser therapy (660\u2009nm, 30\u2009mW, 8\u2009sec, 6\u2009J\/cm\n                    <jats:sup>2<\/jats:sup>\n                    , beam area of 0.04\u2009mm\n                    <jats:sup>2<\/jats:sup>\n                    ), three times per week, totaling 10 sessions. Ulcer areas were analyzed by their nominal area and photographed for analysis through the ImageJ\n                    <jats:sup>\u00ae<\/jats:sup>\n                    software. Then, the Ulcer Healing Index and the wound area reduction were calculated for both groups.\n                    <jats:bold>\n                      <jats:italic toggle=\"yes\">Results:<\/jats:italic>\n                    <\/jats:bold>\n                    Data from the UHI and wound area reduction parameters show that there is a statistically significant difference (\n                    <jats:italic toggle=\"yes\">p<\/jats:italic>\n                    \u2009&lt;\u20090.05) between the control group and PDT group, with the PDT group showing a greater reduction of the diabetic ulcer area than the control group. In the ImageJ software area analysis, both patient groups presented significant differences (\n                    <jats:italic toggle=\"yes\">p<\/jats:italic>\n                    \u2009&lt;\u20090.05) between pre and post-treatment in relation to lesion reduction area, the PDT being better.\n                    <jats:bold>\n                      <jats:italic toggle=\"yes\">Conclusions:<\/jats:italic>\n                    <\/jats:bold>\n                    Results show that PDT accelerates the closure of ulcer wounds and to evaluate the wound area, different measurement methods can be used to follow-up the tissue repair process.\n                  <\/jats:p>","DOI":"10.1089\/pho.2017.4305","type":"journal-article","created":{"date-parts":[[2017,10,12]],"date-time":"2017-10-12T12:25:59Z","timestamp":1507811159000},"page":"44-50","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":26,"title":["A Study on the Macroscopic Morphometry of the Lesion Area on Diabetic Ulcers in Humans Treated with Photodynamic Therapy Using Two Methods of Measurement"],"prefix":"10.1177","volume":"36","author":[{"given":"Patr\u00edcia Michelassi","family":"Carrinho","sequence":"first","affiliation":[{"name":"Brazil University","place":["Brazil"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dora In\u00e9s Kozusny","family":"Andreani","sequence":"additional","affiliation":[{"name":"Brazil University","place":["Brazil"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vislaine de Aguiar","family":"Morete","sequence":"additional","affiliation":[{"name":"Brazil University","place":["Brazil"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shizumi","family":"Iseri","sequence":"additional","affiliation":[{"name":"Brazil University","place":["Brazil"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ricardo Scarparo","family":"Navarro","sequence":"additional","affiliation":[{"name":"Brazil University","place":["Brazil"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antonio Balbin","family":"Villaverde","sequence":"additional","affiliation":[{"name":"Anhembi Morumbi University (UAM)","place":["Brazil"]},{"name":"Technology and Education\u2014CIT\u00c9","place":["Brazil"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2018,1]]},"reference":[{"key":"e_1_3_3_2_2","first-page":"157","article-title":"Management of diabetic skin wounds with a natural l\u00e1tex biomembrane","volume":"32","author":"Frade MAC","year":"2004","unstructured":"Frade MAC, , Cursi IB, , Andrade FF, , Coutinho-Netto J, , Barbetta FM, , Foss NT. 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