{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T17:02:46Z","timestamp":1790874166943,"version":"4.1.0"},"reference-count":46,"publisher":"SAGE Publications","issue":"11","license":[{"start":{"date-parts":[[2018,11,1]],"date-time":"2018-11-01T00:00:00Z","timestamp":1541030400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Photomedicine and Laser Surgery"],"published-print":{"date-parts":[[2018,11]]},"abstract":"<jats:sec>\n                    <jats:title>Objective:<\/jats:title>\n                    <jats:p>The aim of this study was to compare the effects of laser photobiomodulation (PBM) and topical ozone therapy on the reepithelialization of palatal donor site wounds through clinical assessment and computer-aided image analysis and to assess the patient morbidity following free gingival graft (FGG) surgeries.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Material and methods:<\/jats:title>\n                    <jats:p>\n                      Thirty-six patients requiring FGG were randomly allocated into three groups: laser group (\n                      <jats:italic toggle=\"yes\">n<\/jats:italic>\n                      \u2009=\u200912), ozone group (\n                      <jats:italic toggle=\"yes\">n<\/jats:italic>\n                      \u2009=\u200912), and control group (\n                      <jats:italic toggle=\"yes\">n<\/jats:italic>\n                      \u2009=\u200912). Epithelialization was evaluated by applying 3% hydrogen peroxide (H\n                      <jats:sub>2<\/jats:sub>\n                      O\n                      <jats:sub>2<\/jats:sub>\n                      ) to the wound area and also measured by using digital image analysis (ImageJ). Bland\u2013Altman plots were used for assessing agreement between H\n                      <jats:sub>2<\/jats:sub>\n                      O\n                      <jats:sub>2<\/jats:sub>\n                      and ImageJ measurements. Parameters in relation to patient morbidity were assessed by using visual analog scale (VAS) on the first 3, 7, 14, and 30 days postoperatively.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>\n                      At day 14, statistically significant smaller wounds were observed with digital image analysis in the ozone group as compared with the control group (\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      \u2009=\u20090.034). However, intergroup comparison of the remaining wound area evaluated by the clinician using the H\n                      <jats:sub>2<\/jats:sub>\n                      O\n                      <jats:sub>2<\/jats:sub>\n                      method did not reveal any significant differences (\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      \u2009&gt;\u20090.05). Nonetheless, according to Bland\u2013Altman analysis, the lower and upper limits showed a moderate agreement between the two measurement methods. The mean VAS sores exhibiting postoperative discomfort was observed to be significantly higher in the control group compared with the laser group (\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      \u2009=\u20090.002) and ozone group (\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      \u2009&lt;\u20090.001) at day 7.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions:<\/jats:title>\n                    <jats:p>Adjunctive ozone therapy could have a significantly beneficial effect on the acceleration of palatal wound healing following FGG procedures. Both PBM and ozone treatment modalities reduced postoperative discomfort as compared with spontaneous healing.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1089\/pho.2018.4492","type":"journal-article","created":{"date-parts":[[2018,9,27]],"date-time":"2018-09-27T15:52:53Z","timestamp":1538063573000},"page":"571-580","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":56,"title":["Effects of Laser Photobiomodulation and Ozone Therapy on Palatal Epithelial Wound Healing and Patient Morbidity"],"prefix":"10.1177","volume":"36","author":[{"given":"Sila Cagri","family":"Isler","sequence":"first","affiliation":[{"name":"Gazi University","place":["Turkey"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ahu","family":"Uraz","sequence":"additional","affiliation":[{"name":"Gazi University","place":["Turkey"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Berceste","family":"Guler","sequence":"additional","affiliation":[{"name":"Dumlup\u0131nar University","place":["Turkey"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yucel","family":"Ozdemir","sequence":"additional","affiliation":[{"name":"Gazi University","place":["Turkey"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Serpil","family":"Cula","sequence":"additional","affiliation":[{"name":"Baskent University","place":["Turkey"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Deniz","family":"Cetiner","sequence":"additional","affiliation":[{"name":"Gazi University","place":["Turkey"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2018,11,13]]},"reference":[{"issue":"4","key":"e_1_3_3_2_2","doi-asserted-by":"crossref","first-page":"146","DOI":"10.1111\/j.1600-0501.2009.01784.x","article-title":"A systematic review assessing soft tissue augmentation techniques","volume":"20","author":"Thoma DS","year":"2009","unstructured":"Thoma DS, , Benic GI, , Zwahlen M, , Hammerle CH, , Jung RE. 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