{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T21:20:35Z","timestamp":1777929635086,"version":"3.51.4"},"reference-count":52,"publisher":"SAGE Publications","issue":"5","license":[{"start":{"date-parts":[[2020,5,1]],"date-time":"2020-05-01T00:00:00Z","timestamp":1588291200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Photobiomodulation, Photomedicine, and Laser Surgery"],"published-print":{"date-parts":[[2020,5]]},"abstract":"<jats:sec>\n                    <jats:title>Objective:<\/jats:title>\n                    <jats:p>The aim of this study was to compare the clinical and immunological results of nonsurgical periodontal treatment with or without the erbium, chromium:yttrium\u2013scandium\u2013gallium\u2013garnet (Er,Cr:YSGG) laser.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Background data:<\/jats:title>\n                    <jats:p>As lasers have begun to be used in dentistry, the Er,Cr:YSGG laser has started to attract attention in the field of periodontology.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and methods:<\/jats:title>\n                    <jats:p>Fifty-nine nonsmoking patients with advanced chronic periodontitis were randomly allocated to a test group (full-mouth ultrasonic supra- and subgingival debridement+Er,Cr:YSGG laser application) and a control group (full-mouth ultrasonic supra- and subgingival debridement+root planing with Gracey curettes). The laser parameters were set as follows: 1.5 W output power, pulse mode H (pulse duration of 140\u2009\u03bcs), pulse frequency of 20\u2009Hz, and an air\u2013water spray ratio of 10% air and 15% water. The instrumentation was performed until the operator felt that the root surfaces were adequately debrided. Probing depth (PD), clinical attachment level (CAL), bleeding on probing (BOP), plaque index, interleukin-1 beta (IL-1\u03b2), matrix metalloproteinase-8 (MMP-8), tissue inhibitor metalloproteinase-1 (TIMP-1), and MMP-8\/TIMP-1 levels in gingival crevicular fluid were evaluated at baseline, 6 weeks, and 3 months postoperatively.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>\n                      There were statistically significant differences in PD, which was our primary outcome, and BOP between the groups at both examinations [\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      \u2009&lt;\u20090.001 and\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      \u2009&lt;\u20090.001 (for PD) and\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      \u2009=\u20090.048 and\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      \u2009&lt;\u20090.001 (for BOP), respectively], in favor of the laser group. However, there were no significant differences among groups at any time for CAL gain (\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      \u2009=\u2009563 and\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      \u2009=\u2009369, respectively). No significant differences in MMP-8, TIMP-1, and MMP-8\/TIMP-1 levels were detected among groups. There was a statistically significant difference for IL-1\u03b2 levels among groups at 3-month evaluations in favor of the laser group.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions:<\/jats:title>\n                    <jats:p>Using the Er,Cr:YSGG laser instead of hand instruments in nonsurgical periodontal treatment has shown additional improvements in terms of pocket reduction and gingival bleeding compared with traditional nonsurgical therapy.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1089\/photob.2019.4748","type":"journal-article","created":{"date-parts":[[2020,5,19]],"date-time":"2020-05-19T17:48:56Z","timestamp":1589910536000},"page":"316-322","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":1,"title":["Clinical and Immunological Effects of Er,Cr:YSGG Laser in Nonsurgical Periodontal Treatment: A Randomized Clinical Trial"],"prefix":"10.1177","volume":"38","author":[{"given":"Deniz","family":"Erbil","sequence":"first","affiliation":[{"name":"Department of Periodontology, Faculty of Dentistry, Istanbul University, Istanbul, Turkey."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kenan","family":"Nazaroglu","sequence":"additional","affiliation":[{"name":"Private practice, Istanbul, Turkey."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ulku","family":"Baser","sequence":"additional","affiliation":[{"name":"Department of Periodontology, Faculty of Dentistry, Istanbul University, Istanbul, Turkey."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Halim","family":"\u0130ssever","sequence":"additional","affiliation":[{"name":"Department of Public Health, Faculty of Medicine, Istanbul University, Istanbul, Turkey."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sevim","family":"Mese","sequence":"additional","affiliation":[{"name":"Department of Virology, Faculty of Medicine, Istanbul University, Istanbul, Turkey."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aysen G.","family":"\u0130sik","sequence":"additional","affiliation":[{"name":"Department of Periodontology, Faculty of Dentistry, Istanbul University, Istanbul, Turkey."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2020,5,19]]},"reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1902\/jop.1986.57.2.69"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-051X.1981.tb02024.x"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-051X.1984.tb01344.x"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.1902\/jop.1974.45.9.672"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/0300-5712(95)00034-8"},{"key":"e_1_3_3_7_2","doi-asserted-by":"publisher","DOI":"10.11607\/prd.2981"},{"key":"e_1_3_3_8_2","doi-asserted-by":"publisher","DOI":"10.1902\/jop.1997.68.12.1151"},{"key":"e_1_3_3_9_2","first-page":"3","article-title":"Removal of bacterial endotoxin from root surface with Er:YAG laser","volume":"16","author":"Folwaczny M","year":"2003","unstructured":"Folwaczny M, , Aggstaller H, , Mehl A, , Hickel R. 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