{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T21:20:52Z","timestamp":1777929652404,"version":"3.51.4"},"reference-count":34,"publisher":"SAGE Publications","issue":"3","license":[{"start":{"date-parts":[[2021,3,1]],"date-time":"2021-03-01T00:00:00Z","timestamp":1614556800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Photobiomodulation, Photomedicine, and Laser Surgery"],"published-print":{"date-parts":[[2021,3]]},"abstract":"<jats:sec>\n                    <jats:title>Objective:<\/jats:title>\n                    <jats:p>To conduct a preliminary assessment of intense pulsed light (IPL) treatment for allergic keratoconjunctivitis (AKC)-associated ocular itch.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>Current control measures for AKC rely primarily on drugs. IPL is effective for dry eye disease (DED). Furthermore, phototherapy is effective for managing skin inflammation and pruritus, suggesting that eye itching could decrease in some patients having AKC complicated with DED following IPL treatment to control dry eye symptoms.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>Thirty-five patients having DED complicated with mid-to-severe AKC were administered three IPL treatments to the periorbital skin. The eye scores of subjective symptoms and signs of AKC and tear film breakup time (TBUT) were retrospectively assessed before and after each treatment.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>The scores for AKC-related symptoms and signs were determined four times: on Day 1 (time 0), Day 15 (time 1), Day 45 (time 2), and Day 75 (time 3) before each treatment. The average symptom score significantly decreased with treatments (time 0: 30.97, time 1: 15.03, time 3: 10). The average sign score for both eyes decreased after the first IPL treatment (left eye: 7.97 vs. 11.38; right eye: 8.1 vs. 11.1). There were no further improvements in the signs after the last treatment. The TBUT value in the right eye increased from times 0 to 3 (2.31 vs. 4.66 vs. 7.71 vs. 7.74). The TBUT value in the left eye increased from times 0 to 3 (2.50 vs. 6.97 vs. 7.57 vs. 8.24).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions:<\/jats:title>\n                    <jats:p>Symptoms and signs improved after IPL treatment in patients with AKC. Eye itching was gradually controlled and rarely recurred. IPL may be effective for AKC treatment.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1089\/photob.2020.4826","type":"journal-article","created":{"date-parts":[[2021,2,24]],"date-time":"2021-02-24T10:01:58Z","timestamp":1614160918000},"page":"196-203","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":10,"title":["Intense Pulsed Light Treatment for Itch Associated with Allergic Keratoconjunctivitis: A Retrospective Study of 35 Cases"],"prefix":"10.1177","volume":"39","author":[{"given":"Dan","family":"Li","sequence":"first","affiliation":[{"name":"Department of Ophthalmology, Joint Shantou International Eye Center of Shantou University and Chinese University of Hong Kong, Shantou, Guangdong, China."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shi-Bin","family":"Lin","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Joint Shantou International Eye Center of Shantou University and Chinese University of Hong Kong, Shantou, Guangdong, China."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Liu-Hang-Hang","family":"Cheng","sequence":"additional","affiliation":[{"name":"Key Laboratory of Tissue Repair and Regeneration of PLA, and Beijing Key Research Laboratory of Skin Injury, Repair and Regeneration, The Fourth Medical Center of General Hospital of PLA, Beijing, P.R. China."},{"name":"Institute of Basic Medical Sciences, General Hospital of PLA, Beijing, P.R. China."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ming-Zhi","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Joint Shantou International Eye Center of Shantou University and Chinese University of Hong Kong, Shantou, Guangdong, China."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Biao","family":"Cheng","sequence":"additional","affiliation":[{"name":"Department of Burn and Plastic Surgery, General Hospital of Southern Theater Command, PLA, Guangzhou, Guangdong, P.R. China."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2021,3,15]]},"reference":[{"key":"e_1_3_5_2_2","doi-asserted-by":"publisher","DOI":"10.1177\/2040622315612745"},{"key":"e_1_3_5_3_2","doi-asserted-by":"publisher","DOI":"10.3109\/03639045.2012.736515"},{"key":"e_1_3_5_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.anai.2019.11.014"},{"key":"e_1_3_5_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9394(14)73983-2"},{"key":"e_1_3_5_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jtos.2017.01.006"},{"key":"e_1_3_5_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.exer.2017.06.011"},{"key":"e_1_3_5_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1542-0124(12)70246-X"},{"key":"e_1_3_5_9_2","first-page":"49","article-title":"Allergic conjunctivitis: current concepts on pathogenesis and management","volume":"32","author":"Sacchetti M","year":"2018","unstructured":"Sacchetti M, , Abicca I, , Bruscolini A, , Cavaliere C, , Nebbioso M, , Lambiase A. Allergic conjunctivitis: current concepts on pathogenesis and management. J Biol Regulat Homeostat Agents, 2018; 32:49\u201360.","journal-title":"J Biol Regulat Homeostat Agents"},{"key":"e_1_3_5_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2004.10.042"},{"key":"e_1_3_5_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2015.08.047"},{"key":"e_1_3_5_12_2","doi-asserted-by":"publisher","DOI":"10.2174\/1872213X11666170913150146"},{"key":"e_1_3_5_13_2","doi-asserted-by":"publisher","DOI":"10.2174\/187221311794474883"},{"key":"e_1_3_5_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.iac.2007.12.005"},{"key":"e_1_3_5_15_2","doi-asserted-by":"publisher","DOI":"10.1089\/pho.2016.4139"},{"key":"e_1_3_5_16_2","doi-asserted-by":"publisher","DOI":"10.3109\/02713683.2015.1088953"},{"key":"e_1_3_5_17_2","doi-asserted-by":"publisher","DOI":"10.1089\/pho.2014.3819"},{"key":"e_1_3_5_18_2","first-page":"1965","article-title":"Prospective evaluation of intense pulsed light (IPL) therapy for meibomian gland dysfunction (MGD)","volume":"56","author":"Craig JP","year":"2014","unstructured":"Craig JP, , Turnbull PR, , Chen A. Prospective evaluation of intense pulsed light (IPL) therapy for meibomian gland dysfunction (MGD). Acta Ophthalmol, 2014; 56:1965\u20131970.","journal-title":"Acta Ophthalmol"},{"key":"e_1_3_5_19_2","doi-asserted-by":"publisher","DOI":"10.1089\/photob.2018.4509"},{"key":"e_1_3_5_20_2","doi-asserted-by":"publisher","DOI":"10.1089\/jop.2009.0087"},{"key":"e_1_3_5_21_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00105-018-4229-z"},{"key":"e_1_3_5_22_2","doi-asserted-by":"publisher","DOI":"10.1111\/jdv.13994"},{"key":"e_1_3_5_23_2","doi-asserted-by":"publisher","DOI":"10.1111\/php.12284"},{"key":"e_1_3_5_24_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1542-0124(12)70112-X"},{"key":"e_1_3_5_25_2","doi-asserted-by":"publisher","DOI":"10.1097\/ACI.0b013e32833e16cc"},{"key":"e_1_3_5_26_2","doi-asserted-by":"publisher","DOI":"10.18176\/jiaci.0320"},{"key":"e_1_3_5_27_2","volume-title":"Role of transient Receptor Potential Channels in Acute and Chronic Itch","author":"Wilson SR","year":"2014","unstructured":"Wilson SR, , Bautista DM. Role of transient Receptor Potential Channels in Acute and Chronic Itch. Boca Raton, FL: CRC Press\/Taylor and Francis, 2014."},{"key":"e_1_3_5_28_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41591-018-0083-x"},{"key":"e_1_3_5_29_2","doi-asserted-by":"publisher","DOI":"10.1097\/00130832-200410000-00014"},{"key":"e_1_3_5_30_2","doi-asserted-by":"publisher","DOI":"10.3109\/15569527.2015.1010727"},{"key":"e_1_3_5_31_2","doi-asserted-by":"publisher","DOI":"10.1093\/pm\/pnv070"},{"key":"e_1_3_5_32_2","doi-asserted-by":"publisher","DOI":"10.1159\/000363043"},{"key":"e_1_3_5_33_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00418-012-0924-5"},{"key":"e_1_3_5_34_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajo.2017.08.021"},{"key":"e_1_3_5_35_2","doi-asserted-by":"publisher","DOI":"10.3109\/02713683.2012.747617"}],"container-title":["Photobiomodulation, Photomedicine, and Laser Surgery"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1089\/photob.2020.4826","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1089\/photob.2020.4826","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1089\/photob.2020.4826","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T23:48:03Z","timestamp":1777679283000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1089\/photob.2020.4826"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,3]]},"references-count":34,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2021,3]]}},"alternative-id":["10.1089\/photob.2020.4826"],"URL":"https:\/\/doi.org\/10.1089\/photob.2020.4826","relation":{},"ISSN":["2578-5478","2578-5478"],"issn-type":[{"value":"2578-5478","type":"print"},{"value":"2578-5478","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,3]]}}}