{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,30]],"date-time":"2026-10-30T18:29:28Z","timestamp":1793384968750,"version":"4.5.0"},"reference-count":54,"publisher":"SAGE Publications","issue":"8","license":[{"start":{"date-parts":[[2023,8,1]],"date-time":"2023-08-01T00:00:00Z","timestamp":1690848000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Photobiomodulation, Photomedicine, and Laser Surgery"],"published-print":{"date-parts":[[2023,8]]},"abstract":"<jats:sec>\n                    <jats:title>Objective:<\/jats:title>\n                    <jats:p>\n                      This study evaluated photobiomodulation therapy (PBMT) effects on the factors involved in mitochondrial biogenesis, on the mitochondrial respiratory complexes, and on the transient receptor potential canonical channels (such as TRPC-1 and TRPC-6) in\n                      <jats:italic toggle=\"yes\">in vitro<\/jats:italic>\n                      (mdx muscle cells) and\n                      <jats:italic toggle=\"yes\">in vivo<\/jats:italic>\n                      studies (gastrocnemius muscle) from mdx mice, the dystrophin-deficient model of Duchenne muscular dystrophy (DMD).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>There is no successful treatment for DMD, therefore demanding search for new therapies that can improve the muscle role, the quality of life, and the survival of dystrophic patients.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>The dystrophic primary muscle cells received PBMT at 0.6\u2009J and 5\u2009J, and the dystrophic gastrocnemius muscle received PBMT at 0.6\u2009J.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>\n                      The dystrophic muscle cells treated with PBMT (0.6\u2009J and 5\u2009J) showed no cytotoxicity and significantly lower levels in hydrogen peroxide (H\n                      <jats:sub>2<\/jats:sub>\n                      O\n                      <jats:sub>2<\/jats:sub>\n                      ) production. We also demonstrated, for the first time, the capacity of PBMT, at a low dose (0.6\u2009J), in reducing the TRPC-6 content and in raising the peroxisome proliferator-activated receptor \u03b3 coactivator-1\u03b1 (PGC-1\u03b1) content in the dystrophic gastrocnemius muscle.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions:<\/jats:title>\n                    <jats:p>\n                      PBMT modulates H\n                      <jats:sub>2<\/jats:sub>\n                      O\n                      <jats:sub>2<\/jats:sub>\n                      production, TRPC-6, and PGC-1\u03b1 content in the dystrophic muscle. These results suggest that laser therapy could act as an auxiliary therapy in the treatment of dystrophic patients.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1089\/photob.2022.0115","type":"journal-article","created":{"date-parts":[[2023,8,1]],"date-time":"2023-08-01T13:02:42Z","timestamp":1690894962000},"page":"389-401","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":3,"title":["Low-Level Photobiomodulation Therapy Modulates H\n                    <sub>2<\/sub>\n                    O\n                    <sub>2<\/sub>\n                    Production, TRPC-6, and PGC-1\u03b1 Levels in the Dystrophic Muscle"],"prefix":"10.1177","volume":"41","author":[{"given":"Caroline","family":"Covatti","sequence":"first","affiliation":[{"name":"Departamento de Biologia Estrutural e Funcional, Instituto de Biologia, Universidade Estadual de Campinas (UNICAMP), Campinas, S\u00e3o Paulo, Brazil."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniela Sayuri","family":"Mizobuti","sequence":"additional","affiliation":[{"name":"Departamento de Biologia Estrutural e Funcional, Instituto de Biologia, Universidade Estadual de Campinas (UNICAMP), Campinas, S\u00e3o Paulo, Brazil."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guilherme Luiz da","family":"Rocha","sequence":"additional","affiliation":[{"name":"Departamento de Biologia Estrutural e Funcional, Instituto de Biologia, Universidade Estadual de Campinas (UNICAMP), Campinas, S\u00e3o Paulo, Brazil."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Heloina Nathalli\u00ea Mariano","family":"da Silva","sequence":"additional","affiliation":[{"name":"Departamento de Biologia Estrutural e Funcional, Instituto de Biologia, Universidade Estadual de Campinas (UNICAMP), Campinas, S\u00e3o Paulo, Brazil."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Caroline Caramano","family":"de Louren\u00e7o","sequence":"additional","affiliation":[{"name":"Departamento de Biologia Estrutural e Funcional, Instituto de Biologia, Universidade Estadual de Campinas (UNICAMP), Campinas, S\u00e3o Paulo, Brazil."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adriana","family":"Pertille","sequence":"additional","affiliation":[{"name":"Graduate Program in Science of Human Movement, Universidade Metodista de Piracicaba (UNIMEP), Piracicaba, S\u00e3o Paulo, Brazil."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elaine Cristina Leite","family":"Pereira","sequence":"additional","affiliation":[{"name":"Departamento de Biologia Estrutural e Funcional, Instituto de Biologia, Universidade Estadual de Campinas (UNICAMP), Campinas, S\u00e3o Paulo, Brazil."},{"name":"Universidade de Bras\u00edlia (UnB), Faculdade de Ceil\u00e2ndia, Bras\u00edlia, Distrito Federal, Brazil."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9863-0761","authenticated-orcid":false,"given":"Elaine","family":"Minatel","sequence":"additional","affiliation":[{"name":"Departamento de Biologia Estrutural e Funcional, Instituto de Biologia, Universidade Estadual de Campinas (UNICAMP), Campinas, S\u00e3o Paulo, Brazil."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2023,8,9]]},"reference":[{"key":"e_1_3_5_2_2","doi-asserted-by":"publisher","DOI":"10.1109\/JSTQE.2016.2561201"},{"key":"e_1_3_5_3_2","doi-asserted-by":"publisher","DOI":"10.1111\/php.12864"},{"key":"e_1_3_5_4_2","doi-asserted-by":"publisher","DOI":"10.2203\/dose-response.14-032.Agrawal"},{"key":"e_1_3_5_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jphotobiol.2013.06.004"},{"key":"e_1_3_5_6_2","doi-asserted-by":"publisher","DOI":"10.1515\/plm-2012-0032"},{"key":"e_1_3_5_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jphotobiol.2019.111513"},{"key":"e_1_3_5_8_2","doi-asserted-by":"publisher","DOI":"10.1155\/2021\/5519709"},{"key":"e_1_3_5_9_2","doi-asserted-by":"publisher","DOI":"10.1007\/s10103-015-1777-7"},{"key":"e_1_3_5_10_2","doi-asserted-by":"publisher","DOI":"10.1111\/php.13179"},{"key":"e_1_3_5_11_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0128567"},{"key":"e_1_3_5_12_2","first-page":"14","article-title":"Markers of oxidative stress and aging in Duchene muscular dystrophy patients and the possible ameliorating effect of He:Ne laser","volume":"26","author":"Abdel Salam E","year":"2007","unstructured":"Abdel Salam E, , Abdel-Meguid I, , Korraa S. 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