{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T21:22:54Z","timestamp":1777929774261,"version":"3.51.4"},"reference-count":51,"publisher":"SAGE Publications","issue":"2","license":[{"start":{"date-parts":[[2024,2,1]],"date-time":"2024-02-01T00:00:00Z","timestamp":1706745600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Photobiomodulation, Photomedicine, and Laser Surgery"],"published-print":{"date-parts":[[2024,2]]},"abstract":"<jats:sec>\n                    <jats:title>Objective:<\/jats:title>\n                    <jats:p>\n                      To evaluate effectiveness of Fotoenticine (FTC)-mediated photodynamic therapy (PDT) and\n                      <jats:italic toggle=\"yes\">Sapindus mukorossi<\/jats:italic>\n                      (SM) as adjunct to mechanical debridement (MD) on peri-implant clinical parameters and levels of proinflammatory cytokines among diabetics.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>\n                      FTC has exhibited robust photodynamic impact against\n                      <jats:italic toggle=\"yes\">Streptococcus mutans<\/jats:italic>\n                      (i.e., an established caries-associated bacterium); however, its efficacy against periodontal pathogens is not known.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>\n                      <jats:italic toggle=\"yes\">Methods<\/jats:italic>\n                      :\n                    <\/jats:title>\n                    <jats:p>One hundred six diabetics with peri-implantitis were randomly categorized into three groups: Group I consisted of 37 participants who were treated with only MD; group II comprised 35 participants who were treated with FTC-mediated PDT, in addition to MD; and group III consisted of 34 participants who were treated with SM, in addition to MD. Peri-implant clinical parameters [plaque index (PI), bleeding on probing (BOP), and probing depth (PD)] and radiographic outcomes [crestal bone loss (CBL)] (PI, BOP, and PD), together with peri-implant sulcular fluid (PISF) interleukin (IL)-1\u03b2 and IL-6 levels were measured at baseline and 6-month follow-up.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>\n                      In group I (\n                      <jats:italic toggle=\"yes\">n<\/jats:italic>\n                      \u2009=\u200937; 24 males +13 females), group II (\n                      <jats:italic toggle=\"yes\">n<\/jats:italic>\n                      \u2009=\u200935; 20 males +15 females), and group III (\n                      <jats:italic toggle=\"yes\">n<\/jats:italic>\n                      \u2009=\u200934; 17 males +17 females), the mean age of participants was 54.3\u2009\u00b1\u20094.6, 52.0\u2009\u00b1\u20095.5, and 50.8\u2009\u00b1\u20094.5 years, respectively. Significant improvement was observed in the scores of peri-implant PI (\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      \u2009=\u20090.01), BOP (\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      \u2009=\u20090.01), and PD (\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      \u2009=\u20090.02) at the 6-month follow-up among all study groups. Significant improvement in peri-implant CBL among group I subjects at 6-month follow-up compared to baseline (\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      \u2009&lt;\u20090.05) was observed. PISF levels of IL-1\u03b2 and IL-6 improved at 6 months.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>\n                      <jats:italic toggle=\"yes\">Conclusions<\/jats:italic>\n                      :\n                    <\/jats:title>\n                    <jats:p>As an adjunct to conventional MD, FTC-mediated PDT and SM might be used as potential therapeutic modalities among diabetics with peri-implantitis.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1089\/photob.2023.0164","type":"journal-article","created":{"date-parts":[[2024,2,1]],"date-time":"2024-02-01T16:18:46Z","timestamp":1706804326000},"page":"174-181","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["Efficacy of Adjunctive Fotoenticine Photodynamic Therapy and\n                    <i>Sapindus mukorossi<\/i>\n                    Therapy on Clinical, Radiographic, and Cytokine Profile of Diabetics with Peri-Implantitis"],"prefix":"10.1177","volume":"42","author":[{"given":"Mohammed N.","family":"Alasqah","sequence":"first","affiliation":[{"name":"Department of Preventive Dental Sciences, College of Dentistry, Prince Sattam bin Abdulaziz University, Alkharj, Kingdom of Saudi Arabia."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2024,2,19]]},"reference":[{"key":"e_1_3_6_2_2","article-title":"The application of antimicrobial photodynamic therapy (aPDT) in the treatment of peri-implantitis","volume":"2022","author":"Zhao T","year":"2022","unstructured":"Zhao T, , Song J, , Ping Y, et al. The application of antimicrobial photodynamic therapy (aPDT) in the treatment of peri-implantitis. Comput Math Methods Med, 2022; 2022:3547398.","journal-title":"Comput Math Methods Med"},{"issue":"20","key":"e_1_3_6_3_2","first-page":"S1","article-title":"A new classification scheme for periodontal and peri-implant diseases and conditions\u2014Introduction and key changes from the 1999 classification","volume":"45","author":"Caton JG","year":"2018","unstructured":"Caton JG, , Armitage G, , Berglundh T, et al. A new classification scheme for periodontal and peri-implant diseases and conditions\u2014Introduction and key changes from the 1999 classification. J Clin Periodontol, 2018; 45 Suppl 20:S1\u2013S8.","journal-title":"J Clin Periodontol"},{"key":"e_1_3_6_4_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-051X.2008.01274.x"},{"key":"e_1_3_6_5_2","doi-asserted-by":"publisher","DOI":"10.1111\/idh.12399"},{"key":"e_1_3_6_6_2","doi-asserted-by":"publisher","DOI":"10.1097\/ID.0000000000000868"},{"issue":"7","key":"e_1_3_6_7_2","first-page":"783","article-title":"Antimicrobial photodynamic therapy for the treatment of periodontitis and peri-implantitis: An American Academy of Periodontology best evidence review","volume":"89","author":"Chambrone L","year":"2018","unstructured":"Chambrone L, , Wang HL, , Romanos GE. Antimicrobial photodynamic therapy for the treatment of periodontitis and peri-implantitis: An American Academy of Periodontology best evidence review. J Periodontol, 2018; 89(7):783\u2013803.","journal-title":"J Periodontol"},{"key":"e_1_3_6_8_2","doi-asserted-by":"publisher","DOI":"10.1007\/s10103-012-1148-6"},{"key":"e_1_3_6_9_2","doi-asserted-by":"publisher","DOI":"10.2103\/7\/fomm"},{"key":"e_1_3_6_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.pdpdt.2020.102001"},{"key":"e_1_3_6_11_2","doi-asserted-by":"publisher","DOI":"10.1080\/21505594.2021.1960105"},{"key":"e_1_3_6_12_2","doi-asserted-by":"publisher","DOI":"10.3389\/fmicb.2018.01299"},{"key":"e_1_3_6_13_2","doi-asserted-by":"publisher","DOI":"10.1155\/2014\/824538"},{"key":"e_1_3_6_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajodo.2018.03.027"},{"key":"e_1_3_6_15_2","doi-asserted-by":"publisher","DOI":"10.3390\/pharmaceutics13091399"},{"key":"e_1_3_6_16_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.mib.2016.06.008"},{"key":"e_1_3_6_17_2","doi-asserted-by":"publisher","DOI":"10.1042\/BJ20150942"},{"key":"e_1_3_6_18_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.pdpdt.2020.101817"},{"key":"e_1_3_6_19_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.pdpdt.2021.102303"},{"key":"e_1_3_6_20_2","doi-asserted-by":"publisher","DOI":"10.1007\/s12517-021-09275-6"},{"issue":"7","key":"e_1_3_6_21_2","first-page":"2724","article-title":"Influence of Sapindus mukorossi extract in comparison to 17% EDTA as final root canal irrigant on the sealer penetration and microleakage of dentinal tubules","volume":"27","author":"Tahir A","year":"2023","unstructured":"Tahir A, , Qazi FU-R, , Choudhry Z, et al. Influence of Sapindus mukorossi extract in comparison to 17% EDTA as final root canal irrigant on the sealer penetration and microleakage of dentinal tubules. Eur Rev Med Pharmacol Sci, 2023; 27(7):2724\u20132732.","journal-title":"Eur Rev Med Pharmacol Sci"},{"key":"e_1_3_6_22_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0765.2012.01500.x"},{"key":"e_1_3_6_23_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1708-8208.2007.00076.x"},{"key":"e_1_3_6_24_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1708-8208.2010.00299.x"},{"key":"e_1_3_6_25_2","doi-asserted-by":"publisher","DOI":"10.1111\/jcpe.12127"},{"key":"e_1_3_6_26_2","doi-asserted-by":"publisher","DOI":"10.5037\/jomr.2016.7309"},{"issue":"6","key":"e_1_3_6_27_2","first-page":"969","article-title":"Analysis of the inflammatory process around endosseous dental implants and natural teeth: Myeloperoxidase level and nitric oxide metabolism","volume":"22","author":"T\u00f6z\u00fcm TF","year":"2007","unstructured":"T\u00f6z\u00fcm TF, , Akman AC, , Yamalik N, et al. Analysis of the inflammatory process around endosseous dental implants and natural teeth: Myeloperoxidase level and nitric oxide metabolism. Int J Oral Maxillofac Implants, 2007; 22(6):969\u2013979.","journal-title":"Int J Oral Maxillofac Implants"},{"key":"e_1_3_6_28_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0501.2010.02044.x"},{"key":"e_1_3_6_29_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.archoralbio.2016.08.020"},{"key":"e_1_3_6_30_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jphotobiol.2017.08.012"},{"key":"e_1_3_6_31_2","doi-asserted-by":"publisher","DOI":"10.1002\/JPER.17-0739"},{"key":"e_1_3_6_32_2","doi-asserted-by":"publisher","DOI":"10.2337\/dc14-S081"},{"key":"e_1_3_6_33_2","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2012.120555"},{"key":"e_1_3_6_34_2","doi-asserted-by":"publisher","DOI":"10.1002\/JPER.19-0209"},{"key":"e_1_3_6_35_2","doi-asserted-by":"publisher","DOI":"10.1111\/cid.12575"},{"key":"e_1_3_6_36_2","doi-asserted-by":"publisher","DOI":"10.14219\/jada.archive.2003.0076"},{"key":"e_1_3_6_37_2","doi-asserted-by":"publisher","DOI":"10.1080\/08958378.2018.1449273"},{"key":"e_1_3_6_38_2","doi-asserted-by":"publisher","DOI":"10.1111\/cid.12557"},{"key":"e_1_3_6_39_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.pdpdt.2017.10.013"},{"issue":"8","key":"e_1_3_6_40_2","first-page":"677","article-title":"Photodynamic therapy in periodontal and peri-implant diseases","volume":"46","author":"Habashneh A","year":"2015","unstructured":"Habashneh A, , Asa'ad F, , Khader Y. Photodynamic therapy in periodontal and peri-implant diseases. Quintessence Int, 2015; 46(8):677.","journal-title":"Quintessence Int"},{"key":"e_1_3_6_41_2","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2014.130610"},{"key":"e_1_3_6_42_2","doi-asserted-by":"publisher","DOI":"10.1155\/2016\/7692387"},{"key":"e_1_3_6_43_2","doi-asserted-by":"publisher","DOI":"10.1039\/c4pp00083h"},{"key":"e_1_3_6_44_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.pdpdt.2017.09.005"},{"key":"e_1_3_6_45_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.pdpdt.2018.05.003"},{"key":"e_1_3_6_46_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0501.2012.02494.x"},{"key":"e_1_3_6_47_2","doi-asserted-by":"publisher","DOI":"10.3390\/pharmaceutics13111907"},{"key":"e_1_3_6_48_2","doi-asserted-by":"publisher","DOI":"10.1080\/1040841X.2018.1467876"},{"key":"e_1_3_6_49_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00784-015-1474-8"},{"key":"e_1_3_6_50_2","doi-asserted-by":"publisher","DOI":"10.1590\/1807-3107bor-2017.vol31.0114"},{"key":"e_1_3_6_51_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.pdpdt.2017.11.011"},{"key":"e_1_3_6_52_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.pdpdt.2016.11.016"}],"container-title":["Photobiomodulation, Photomedicine, and Laser Surgery"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1089\/photob.2023.0164","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1089\/photob.2023.0164","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1089\/photob.2023.0164","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T23:53:26Z","timestamp":1777679606000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1089\/photob.2023.0164"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,2]]},"references-count":51,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2024,2]]}},"alternative-id":["10.1089\/photob.2023.0164"],"URL":"https:\/\/doi.org\/10.1089\/photob.2023.0164","relation":{},"ISSN":["2578-5478","2578-5478"],"issn-type":[{"value":"2578-5478","type":"print"},{"value":"2578-5478","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,2]]}}}