{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T21:24:07Z","timestamp":1777929847982,"version":"3.51.4"},"reference-count":14,"publisher":"SAGE Publications","issue":"1","license":[{"start":{"date-parts":[[2021,2,1]],"date-time":"2021-02-01T00:00:00Z","timestamp":1612137600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2021,2,1]],"date-time":"2021-02-01T00:00:00Z","timestamp":1612137600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Palliative Medicine Reports"],"published-print":{"date-parts":[[2021,2]]},"abstract":"<jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>Despite the significant palliative care needs for people living with amyotrophic lateral sclerosis (ALS), palliative medicine in Japan is mainly focused on oncologic disease.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective:<\/jats:title>\n                    <jats:p>To compare the care provided to patients with ALS with and without intervention from the palliative care team (PCT and non-PCT groups, respectively).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Design:<\/jats:title>\n                    <jats:p>This is a retrospective case\u2013control study.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Setting:<\/jats:title>\n                    <jats:p>One ALS center in Japan.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Participants:<\/jats:title>\n                    <jats:p>Sixty patients with clinically definite ALS treated until death from January 2012 to December 2019.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Measurements:<\/jats:title>\n                    <jats:p>We compared the two groups based on the presence of advance directives, patient age, use of noninvasive and invasive ventilation, maximum opioid dosage, and use of nonopioid palliative medications such as antidepressants and anxiolytics. We also compared the prescribing practices of the attending physicians.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>\n                      There was no difference in the rate of advance directive completion between the PCT and non-PCT groups. Although all but one patient in the PCT group used opioids, only half of the patients in the non-PCT group used opioids (\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      \u2009&lt;\u20090.001). The mean maximum opioid dosage was higher in the PCT group than in the non-PCT group (\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      \u2009=\u20090.003). Moreover, 79.2% and 41.7% of the PCT and non-PCT groups, respectively, received antidepressants or antianxiety agents (\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      \u2009=\u20090.004). Maximum opioid dosages were not different on the basis of attending physician's experience level.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions:<\/jats:title>\n                    <jats:p>Opioid and nonopioid medications intended for symptom management were more likely to be prescribed to patients with ALS who received intervention from a PCT.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1089\/pmr.2020.0084","type":"journal-article","created":{"date-parts":[[2021,7,6]],"date-time":"2021-07-06T09:37:33Z","timestamp":1625564253000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":3,"title":["Difference in the Care of Patients with Amyotrophic Lateral Sclerosis With and Without Intervention from the Palliative Care Team: Observations from a Center in Japan"],"prefix":"10.1177","volume":"2","author":[{"given":"Kazuya","family":"Takahashi","sequence":"first","affiliation":[{"name":"Department of Neurology, Hokuriku Brain and Neuromuscular Disease Center, National Hospital Organization Iou National Hospital, Kanazawa, Japan."},{"name":"Palliative Care Team, Hokuriku Brain and Neuromuscular Disease Center, National Hospital Organization Iou National Hospital, Kanazawa, Japan."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fumi","family":"Murakami","sequence":"additional","affiliation":[{"name":"Palliative Care Team, Hokuriku Brain and Neuromuscular Disease Center, National Hospital Organization Iou National Hospital, Kanazawa, Japan."},{"name":"Nursing Unit, Hokuriku Brain and Neuromuscular Disease Center, National Hospital Organization Iou National Hospital, Kanazawa, Japan."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kiyonobu","family":"Komai","sequence":"additional","affiliation":[{"name":"Department of Neurology, Hokuriku Brain and Neuromuscular Disease Center, National Hospital Organization Iou National Hospital, Kanazawa, Japan."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chiho","family":"Ishida","sequence":"additional","affiliation":[{"name":"Department of Neurology, Hokuriku Brain and Neuromuscular Disease Center, National Hospital Organization Iou National Hospital, Kanazawa, Japan."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuko","family":"Kato-Motozaki","sequence":"additional","affiliation":[{"name":"Department of Neurology, Hokuriku Brain and Neuromuscular Disease Center, National Hospital Organization Iou National Hospital, Kanazawa, Japan."},{"name":"Palliative Care Team, Hokuriku Brain and Neuromuscular Disease Center, National Hospital Organization Iou National Hospital, Kanazawa, Japan."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2021,7,6]]},"reference":[{"key":"e_1_3_5_2_2","doi-asserted-by":"crossref","first-page":"1218","DOI":"10.1212\/WNL.0b013e3181bc0141","volume":"73","author":"Miller RG","unstructured":"Miller RG, , Jackson CE, , Kasarskis EJ, et al.: Practice parameter update: The care of the patient with amyotrophic lateral sclerosis: Drug, nutritional, and respiratory therapies (an evidence-based review): Report of the Quality Standards Subcommittee of the American Academy of Neurology. Neurology 2009;73:1218\u20131226.","journal-title":"Neurology"},{"key":"e_1_3_5_3_2","doi-asserted-by":"crossref","first-page":"1144","DOI":"10.1136\/jnnp.2009.201251","volume":"81","author":"Mateen FJ","unstructured":"Mateen FJ, , Carone M, , Sorenson EJ, : Patients who survive 5 years or more with ALS in Olmsted County, 1925\u20132004. J Neurol Neurosurg Psychiatry 2010;81:1144\u20131146.","journal-title":"J Neurol Neurosurg Psychiatry"},{"key":"e_1_3_5_4_2","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1136\/jnnp.2011.241349","volume":"83","author":"Weber M","unstructured":"Weber M, , Neuwirth C, , Thierbach J, et al.: ALS patients with SOD1 mutations in Switzerland show very diverse phenotypes and extremely long survival. J Neurol Neurosurg Psychiatry 2012;83:351\u2013353.","journal-title":"J Neurol Neurosurg Psychiatry"},{"key":"e_1_3_5_5_2","author":"Ogino M","unstructured":"Ogino M, : End of life care for patients with ALS in Japan. Rinsho Shinkeigaku 2008;48:973\u2013975. [In Japanese.]","journal-title":"Rinsho Shinkeigaku"},{"key":"e_1_3_5_6_2","unstructured":"Japanese Society for Palliative Medicine:. 2019 Palliative Care Team Registration Report. https:\/\/www.jspm.ne.jp\/pct\/report_jspmpct2019.pdf (accessed October23 2020). [In Japanese.]"},{"key":"e_1_3_5_7_2","doi-asserted-by":"crossref","first-page":"196","DOI":"10.3109\/21678421.2014.994530","volume":"16","author":"Stephens HE","unstructured":"Stephens HE, , Felgoise S, , Young J, , Simmons Z, : Multidisciplinary ALS clinics in the USA: A comparison of those who attend and those who do not. 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Muscle Nerve 2019;60:137\u2013140.","journal-title":"Muscle Nerve"},{"key":"e_1_3_5_10_2","unstructured":"Japanese Society for Palliative Medicine:. 2019 Palliative Care Team Registration Report. https:\/\/www.jspm.ne.jp\/nintei\/senmoni.php (accessed October23 2020). [In Japanese.]"},{"key":"e_1_3_5_11_2","unstructured":"Japanese Nursing Association. https:\/\/nintei.nurse.or.jp\/nursing\/qualification\/cn (accessed October23 2020). [In Japanese.]"},{"key":"e_1_3_5_12_2","unstructured":"Societas Neurologica Laponica: Practice Guidelines for Amyotrophic Lateral Sclerosis. Tokyo: Nankodo 2013."},{"key":"e_1_3_5_13_2","author":"Ogino M","unstructured":"Ogino M, : Survey report on end-of-life care for ALS patients of ALS physicians in Japan. Rinsho Shinkeigaku 2010;50:1026\u20131028. [In Japanese.]","journal-title":"Rinsho Shinkeigaku"},{"key":"e_1_3_5_14_2","doi-asserted-by":"crossref","unstructured":"Kawata A Mizoguchi K Hayashi H : A nationwide survey of ALS patients on tracheostomy positive pressure ventilation (TPPV) who developed a totally locked-in state (TLS) in Japan. Rinsho Shinkeigaku 2008;48:476\u2013480. [In Japanese.]","DOI":"10.5692\/clinicalneurol.48.476"},{"key":"e_1_3_5_15_2","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1212\/01.WNL.0000069925.02052.1F","volume":"61","author":"Hayashi H","unstructured":"Hayashi H, , Oppenheimer EA: ALS patients on TPPV: Totally locked-in state, neurologic findings and ethical implications. 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