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This case report describes a patient with chronic lymphocytic leukemia whose diagnosis of RS3PE was possibly delayed due to concomitant treatment-related arthralgias. The pathophysiology, presentation, and treatment of RS3PE are discussed. Greater awareness of malignancy-related RS3PE is crucial from a palliative care perspective as typical opioid pain management will prove ineffective and delay appropriate treatment.<\/jats:p>","DOI":"10.1089\/pmr.2021.0070","type":"journal-article","created":{"date-parts":[[2022,12,28]],"date-time":"2022-12-28T14:18:21Z","timestamp":1672237101000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":1,"title":["Case Report: Syndrome of Remitting Seronegative Symmetrical Synovitis with Pitting Edema\u2014A Rare but Treatable Condition in Palliative Medicine"],"prefix":"10.1177","volume":"3","author":[{"given":"L. 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