{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T21:24:57Z","timestamp":1777929897061,"version":"3.51.4"},"reference-count":36,"publisher":"SAGE Publications","issue":"1","license":[{"start":{"date-parts":[[2022,8,1]],"date-time":"2022-08-01T00:00:00Z","timestamp":1659312000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2022,8,1]],"date-time":"2022-08-01T00:00:00Z","timestamp":1659312000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Palliative Medicine Reports"],"published-print":{"date-parts":[[2022,8]]},"abstract":"<jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>Patients with advanced cancer and bone metastases may have unmet palliative care (PC) needs that go unnoticed during clinical oncological practice. This observational study describes interventions that were initiated as the patients participated in the Palliative Radiotherapy and Inflammation Study (PRAIS). It was hypothesized that the patients would benefit from study participation due to PC interventions initiated by the study team.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>A retrospective review of patients' electronic records. Patients with advanced cancer and painful bone metastases included in PRAIS were eligible. All patients met with the study team before start of radiotherapy, after completion of Patient Reported Outcome Measures. Interventions initiated by the study team were documented in the patients' electronic records.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>\n                      A total of 133 patients were reviewed: 63% males, mean (standard deviation [SD]) age 65 (9.6) and mean (SD) Karnofsky performance status (KPS) score 73.2 (9.1). Interventions were initiated in 50% (\n                      <jats:italic toggle=\"yes\">n<\/jats:italic>\n                      \u2009=\u200967) of the patients. Changes in opioid management (69%), treatment of constipation (43%), and nausea (24%) and nutritional advice were most frequent (21%). Patients receiving interventions had lower mean KPS (70 vs. 77\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      \u2009&lt;\u20090.001), shorter survival time after study inclusion (median 28 vs. 57.5 weeks\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      \u2009=\u20090.005) and were more often opioid na\u00efve (12% vs. 39%\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      \u2009&lt;\u20090.001) than those not receiving interventions by the study team.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions:<\/jats:title>\n                    <jats:p>Patients with advanced cancer and painful bone metastasis benefited from study participation due to multiple PC interventions initiated by the study team. The findings call for a systematic integration of PC in patients with advanced cancer.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>\n                      <jats:italic toggle=\"yes\">Trial Registration<\/jats:italic>\n                      :\n                    <\/jats:title>\n                    <jats:p>\n                      <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"http:\/\/ClinicalTrials.gov\">ClinicalTrials.gov<\/jats:ext-link>\n                      NCT02107664.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1089\/pmr.2022.0044","type":"journal-article","created":{"date-parts":[[2022,11,7]],"date-time":"2022-11-07T12:12:04Z","timestamp":1667823124000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":4,"title":["Benefits of Study Participation for Patients with Advanced Cancer Receiving Radiotherapy: A Prospective Observational Study"],"prefix":"10.1177","volume":"3","author":[{"given":"Asta","family":"Bye","sequence":"first","affiliation":[{"name":"Department of Nursing and Health Promotion, Faculty of Health Sciences, OsloMet - Oslo Metropolitan University, Oslo, Norway."},{"name":"European Palliative Care Research Centre, Department of Oncology, Oslo University Hospital, and Institute of Clinical Medicine, University of Oslo, Oslo, Norway."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ellen","family":"Bjerkeset","sequence":"additional","affiliation":[{"name":"Regional Advisory Unit for Palliative Care, Department of Oncology, Oslo University Hospital, Oslo, Norway."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hanne","family":"Stensheim","sequence":"additional","affiliation":[{"name":"Department of Research, Cancer Registry of Norway, Oslo, Norway."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jon H.","family":"Loge","sequence":"additional","affiliation":[{"name":"Institute of Basic Medical Sciences, University of Oslo, Oslo, Norway."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marianne J.","family":"Hjermstad","sequence":"additional","affiliation":[{"name":"European Palliative Care Research Centre, Department of Oncology, Oslo University Hospital, and Institute of Clinical Medicine, University of Oslo, Oslo, Norway."},{"name":"Regional Advisory Unit for Palliative Care, Department of Oncology, Oslo University Hospital, Oslo, Norway."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pal","family":"Klepstad","sequence":"additional","affiliation":[{"name":"Department of Circulation and Medical Imaging, Norwegian University of Science and Technology (NTNU), Trondheim, Norway."},{"name":"Department of Anesthesiology and Intensive Care Medicine, St Olavs Hospital, Trondheim University Hospital, Trondheim, Norway."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ragnhild","family":"Habberstad","sequence":"additional","affiliation":[{"name":"European Palliative Care Research Centre, Department of Oncology, Oslo University Hospital, and Institute of Clinical Medicine, University of Oslo, Oslo, Norway."},{"name":"Cancer Clinic, St. Olavs Hospital, Trondheim University Hospital, Trondheim, Norway."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stein","family":"Kaasa","sequence":"additional","affiliation":[{"name":"European Palliative Care Research Centre, Department of Oncology, Oslo University Hospital, and Institute of Clinical Medicine, University of Oslo, Oslo, Norway."},{"name":"Regional Advisory Unit for Palliative Care, Department of Oncology, Oslo University Hospital, Oslo, Norway."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nina","family":"Aass","sequence":"additional","affiliation":[{"name":"European Palliative Care Research Centre, Department of Oncology, Oslo University Hospital, and Institute of Clinical Medicine, University of Oslo, Oslo, Norway."},{"name":"Regional Advisory Unit for Palliative Care, Department of Oncology, Oslo University Hospital, Oslo, Norway."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2022,11,3]]},"reference":[{"key":"e_1_3_5_2_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF03256842"},{"key":"e_1_3_5_3_2","doi-asserted-by":"publisher","DOI":"10.1111\/jan.14712"},{"issue":"1","key":"e_1_3_5_4_2","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/1471-2288-12-123","article-title":"Patient, caregiver, health professional and researcher views and experiences of participating in research at the end of life: A critical interpretive synthesis of the literature","volume":"12","author":"Gysels MH","year":"2012","unstructured":"Gysels MH, , Evans C, , Higginson IJ. 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