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This article describes the Two-Generation Clinic (Two-Gen) and model of care. The model combines a dyadic strategy for simultaneous maternal and pediatric care with the collaborative care model in which seamless primary and behavioral health care are delivered to address the physical health, behavioral health, and social service needs of families. The transdisciplinary team includes primary care physicians, nurse practitioners, psychiatrists, obstetrician-gynecologists, social workers, care navigators, and lactation specialists. Dyad clinic visits are coscheduled (at the same time) and colocated (in the same examination room) with the same primary care provider. In the Two-Gen, the majority (89%) of the mothers self-identify as racial and ethnic minorities. More than 40% have a mental health diagnosis. Almost all mothers (97.8%) completed mental health screenings, &gt;50.0% have received counseling from a social worker, 17.2% had a visit with a psychiatrist, and 50.0% received lactation counseling. Over 80% of the children were up to date with their well-child visits and immunizations. The Two-Gen is a promising model of care that has the potential to inform the design of postpartum care models and promote health equity in communities with the highest maternal health disparities.<\/jats:p>","DOI":"10.1089\/pop.2023.0059","type":"journal-article","created":{"date-parts":[[2023,9,7]],"date-time":"2023-09-07T14:19:26Z","timestamp":1694096366000},"page":"275-282","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":13,"title":["Addressing Maternal Health Disparities: Building a Novel Two-Generation Approach to Comprehensive Postpartum Care"],"prefix":"10.1177","volume":"26","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9164-6162","authenticated-orcid":false,"given":"Anne Elizabeth","family":"Glassgow","sequence":"first","affiliation":[{"name":"Department of Medicine, College of Medicine, University of Illinois at Chicago, Chicago, Illinois, USA."},{"name":"Department of Pediatrics, and College of 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