{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,4]],"date-time":"2026-06-04T16:39:57Z","timestamp":1780591197054,"version":"3.54.1"},"reference-count":0,"publisher":"SAGE Publications","issue":"4","license":[{"start":{"date-parts":[[2005,12,1]],"date-time":"2005-12-01T00:00:00Z","timestamp":1133395200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Rejuvenation Research"],"published-print":{"date-parts":[[2005,12]]},"abstract":"<jats:p>\n                    The practice of traditional Chinese medicine (TCM) always emphasizes the prevention of diseases and delaying the onset of senility. In this regard, the maintenance of a balance of Yin and Yang\u2014two opposing components involved in life activities as exemplified by the antagonistic action of the sympathetic and parasympathetic nervous systems\u2014is essential in achieving a healthy condition. Previous studies have shown that long-term treatment with a Yang-invigorating Chinese herbal formula (VI-28) could increase red cell CuZn-superoxide dismutase (SOD) activity in male human subjects. In the present study, we examined the effects of chronic VI-28 treatment (80 and 240 mg\/kg\/day for 30 days) on red cell CuZn-SOD activity as well as mitochondrial functional ability and antioxidant components in various tissues of male and female rats. The results indicated that VI-28 treatment increased red cell CuZn-SOD activity as well as mitochondrial ATP generation capacity, reduced glutathione and \u03b1-tocopherol levels, and Mn-SOD activity in brain, heart, liver, and skeletal muscle tissues in both male and female rats to varying extents. The VI-28\u2013induced increase in mitochondrial antioxidant capacity in various tissues was evidenced by the significant reduction in the extent of reactive oxygen species generation assessed by\n                    <jats:italic toggle=\"yes\">in vitro<\/jats:italic>\n                    measurement. The red cell CuZn-SOD activities correlated positively with tissue mitochondrial antioxidant component levels\/activity. The beneficial effect of VI-28 treatment on mitochondrial functional ability and antioxidant capacity may have clinical implications in the prevention of age-related diseases.\n                  <\/jats:p>","DOI":"10.1089\/rej.2005.8.238","type":"journal-article","created":{"date-parts":[[2005,11,28]],"date-time":"2005-11-28T12:06:02Z","timestamp":1133179562000},"page":"238-247","source":"Crossref","is-referenced-by-count":33,"title":["A Yang-Invigorating Chinese Herbal Formula Enhances Mitochondrial Functional Ability and Antioxidant Capacity in Various Tissues of Male and Female Rats"],"prefix":"10.1177","volume":"8","author":[{"given":"Hoi Yan","family":"Leung","sequence":"first","affiliation":[{"name":"Department of Biochemistry, The Hong Kong University of Science &amp; Technology, Clear Water Bay, Hong Kong SAR, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Po Yee","family":"Chiu","sequence":"additional","affiliation":[{"name":"Department of Biochemistry, The Hong Kong University of Science &amp; Technology, Clear Water Bay, Hong Kong SAR, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michel K.T.","family":"Poon","sequence":"additional","affiliation":[{"name":"Department of Biochemistry, The Hong Kong University of Science &amp; Technology, Clear Water Bay, Hong Kong SAR, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kam Ming","family":"Ko","sequence":"additional","affiliation":[{"name":"Department of Biochemistry, The Hong Kong University of Science &amp; Technology, Clear Water Bay, Hong Kong SAR, China."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2005,12]]},"container-title":["Rejuvenation Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1089\/rej.2005.8.238","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1089\/rej.2005.8.238","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,2]],"date-time":"2026-05-02T01:27:47Z","timestamp":1777685267000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/full\/10.1089\/rej.2005.8.238"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2005,12]]},"references-count":0,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2005,12]]}},"alternative-id":["10.1089\/rej.2005.8.238"],"URL":"https:\/\/doi.org\/10.1089\/rej.2005.8.238","relation":{},"ISSN":["1549-1684","1557-8577"],"issn-type":[{"value":"1549-1684","type":"print"},{"value":"1557-8577","type":"electronic"}],"subject":[],"published":{"date-parts":[[2005,12]]}}}