{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,22]],"date-time":"2026-05-22T07:10:35Z","timestamp":1779433835787,"version":"3.53.1"},"reference-count":0,"publisher":"SAGE Publications","issue":"2","license":[{"start":{"date-parts":[[2008,4,1]],"date-time":"2008-04-01T00:00:00Z","timestamp":1207008000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Rejuvenation Research"],"published-print":{"date-parts":[[2008,4]]},"abstract":"<jats:p>\n                    Prion diseases like Creutzfeldt-Jakob disease in humans or scrapie in sheep and goats are infectious neurodegenerative diseases. Their infectious agent, called prion, is composed mainly of aggregated and misfolded prion protein and non-proteinaceous components. An example of such a common non-proteinaceous secondary component of natural prions is the polysaccharide scaffold. We studied the influence of such a polysaccharide on the conformational transition of PrP applying an\n                    <jats:italic toggle=\"yes\">in vitro<\/jats:italic>\n                    conversion system. Here we report that glycogen supports and accelerates PrP amorphous aggregation similar to seeded aggregation and leads to co-aggregates. Furthermore, PrP fibril formation was highly accelerated in the presence of glycogen.\n                  <\/jats:p>","DOI":"10.1089\/rej.2008.0698","type":"journal-article","created":{"date-parts":[[2008,3,16]],"date-time":"2008-03-16T15:28:15Z","timestamp":1205681295000},"page":"365-369","source":"Crossref","is-referenced-by-count":6,"title":["Aggregation and Amyloid Fibril Formation of the Prion Protein Is Accelerated in the Presence of Glycogen"],"prefix":"10.1177","volume":"11","author":[{"given":"Giannantonio","family":"Panza","sequence":"first","affiliation":[{"name":"Institut f\u00fcr Physikalische Biologie, Heinrich-Heine-Universit\u00e4t, D\u00fcsseldorf, Germany."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jan","family":"St\u00f6hr","sequence":"additional","affiliation":[{"name":"Institut f\u00fcr Physikalische Biologie, Heinrich-Heine-Universit\u00e4t, D\u00fcsseldorf, Germany."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eva","family":"Birkmann","sequence":"additional","affiliation":[{"name":"Institut f\u00fcr Physikalische Biologie, Heinrich-Heine-Universit\u00e4t, D\u00fcsseldorf, Germany."},{"name":"Forschungszentrum J\u00fclich, INB-2\/Molekulare Biophysik II, J\u00fclich, Germany."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Detlev","family":"Riesner","sequence":"additional","affiliation":[{"name":"Institut f\u00fcr Physikalische Biologie, Heinrich-Heine-Universit\u00e4t, D\u00fcsseldorf, Germany."},{"name":"Biologisch-Medizinisches Forschungszentrum, Heinrich-Heine-Universit\u00e4t, D\u00fcsseldorf, Germany."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dieter","family":"Willbold","sequence":"additional","affiliation":[{"name":"Institut f\u00fcr Physikalische Biologie, Heinrich-Heine-Universit\u00e4t, D\u00fcsseldorf, Germany."},{"name":"Forschungszentrum J\u00fclich, INB-2\/Molekulare Biophysik II, J\u00fclich, Germany."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Otto","family":"Baba","sequence":"additional","affiliation":[{"name":"Biostructural Science, Tokyo Medical and Dental University, Tokyo, Japan."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tatsuo","family":"Terashima","sequence":"additional","affiliation":[{"name":"Maxillofacial Anatomy, Tokyo Medical and Dental University, Tokyo, Japan."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christian","family":"Dumpitak","sequence":"additional","affiliation":[{"name":"Institut f\u00fcr Physikalische Biologie, Heinrich-Heine-Universit\u00e4t, D\u00fcsseldorf, Germany."},{"name":"Biologisch-Medizinisches Forschungszentrum, Heinrich-Heine-Universit\u00e4t, D\u00fcsseldorf, Germany."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2008,4,1]]},"container-title":["Rejuvenation Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1089\/rej.2008.0698","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1089\/rej.2008.0698","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,22]],"date-time":"2026-05-22T07:02:56Z","timestamp":1779433376000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1089\/rej.2008.0698"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2008,4]]},"references-count":0,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2008,4]]}},"alternative-id":["10.1089\/rej.2008.0698"],"URL":"https:\/\/doi.org\/10.1089\/rej.2008.0698","relation":{},"ISSN":["1549-1684","1557-8577"],"issn-type":[{"value":"1549-1684","type":"print"},{"value":"1557-8577","type":"electronic"}],"subject":[],"published":{"date-parts":[[2008,4]]}}}