{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T22:13:07Z","timestamp":1777932787786,"version":"3.51.4"},"reference-count":0,"publisher":"SAGE Publications","issue":"3","license":[{"start":{"date-parts":[[2008,6,1]],"date-time":"2008-06-01T00:00:00Z","timestamp":1212278400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Rejuvenation Research"],"published-print":{"date-parts":[[2008,6]]},"abstract":"<jats:p>\n                    Alzheimer's disease (AD) has been demonstrated to be associated with gene variants of\n                    <jats:italic toggle=\"yes\">APOE<\/jats:italic>\n                    , but numerous additional candidate loci exist with varying levels of statistical support. We defined susceptibility sets for AD based on information on 18 genetic loci on chromosome 10q (32 loci) and elsewhere (34 loci) and quantitative traits, including CSF tau and A\n                    <jats:italic toggle=\"yes\">\u03b2<\/jats:italic>\n                    <jats:sub>42<\/jats:sub>\n                    levels. The 938 AD patients and 397 control subjects were enrolled in Scotland and Sweden. A fuzzy latent classification approach\u2014grade-of-membership analysis (GoM)\u2014was taken to identify risk sets. Individuals were automatically related to each set via GoM scores. Set I: unaffected + \u2193CSF tau + \u2191CSF A\n                    <jats:italic toggle=\"yes\">\u03b2<\/jats:italic>\n                    <jats:sub>42<\/jats:sub>\n                    + multiple protective alleles. High intrinsic risk sets II-VI differed in onset age and relevant alleles: close resemblance (i.e., &gt;75% aggregate membership) multiplied risk of AD &gt;100-fold at ages 65 to 84. It is likely that AD has multiple determinants, including\n                    <jats:italic toggle=\"yes\">APOE<\/jats:italic>\n                    polymorphism and gene variants located on chromosome 10q and elsewhere.\n                  <\/jats:p>","DOI":"10.1089\/rej.2008.0742","type":"journal-article","created":{"date-parts":[[2008,7,1]],"date-time":"2008-07-01T14:08:50Z","timestamp":1214921330000},"page":"667-679","source":"Crossref","is-referenced-by-count":7,"title":["Genetic Susceptibility Sets for Alzheimer's Disease Identified from Diverse Candidate Loci"],"prefix":"10.1177","volume":"11","author":[{"given":"Elizabeth H.","family":"Corder","sequence":"first","affiliation":[{"name":"Center for Demographic Studies, Duke University, Durham, North Carolina."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kaj","family":"Blennow","sequence":"additional","affiliation":[{"name":"Department of Clinical Neuroscience and Physiology, Sahlgren's University Hospital, Molndal, Sweden."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jonathan A.","family":"Prince","sequence":"additional","affiliation":[{"name":"Center for Genomics Research, Karolinska Institute, Stockholm, Sweden."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2008,6]]},"container-title":["Rejuvenation Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1089\/rej.2008.0742","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1089\/rej.2008.0742","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,2]],"date-time":"2026-05-02T01:29:18Z","timestamp":1777685358000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/full\/10.1089\/rej.2008.0742"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2008,6]]},"references-count":0,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2008,6]]}},"alternative-id":["10.1089\/rej.2008.0742"],"URL":"https:\/\/doi.org\/10.1089\/rej.2008.0742","relation":{},"ISSN":["1549-1684","1557-8577"],"issn-type":[{"value":"1549-1684","type":"print"},{"value":"1557-8577","type":"electronic"}],"subject":[],"published":{"date-parts":[[2008,6]]}}}