{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T11:43:41Z","timestamp":1789991021290,"version":"4.0.1"},"reference-count":59,"publisher":"SAGE Publications","issue":"4","license":[{"start":{"date-parts":[[2010,8,1]],"date-time":"2010-08-01T00:00:00Z","timestamp":1280620800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Rejuvenation Research"],"published-print":{"date-parts":[[2010,8]]},"abstract":"<jats:p>\n                    Photoaging is the superposition of photodamage (ultraviolet [UV] radiation-induced) on the aging process. It is a major damaging consequence of free radical action. Curcumin (diferuloylmethane) is a phytochemical with diverse antioxidant and antiinflammatory properties. However, it shows a poor topical bioavailability. Therefore, we encapsulated curcumin in elastic vesicles (EVs) and investigated different doses (1, 3, 5 and 10\u2009\u03bcmol) for its\n                    <jats:italic toggle=\"yes\">in vivo<\/jats:italic>\n                    antiaging activity in mice. VICCO\n                    <jats:sup>\u00ae<\/jats:sup>\n                    turmeric served as the marketed control, and free curcumin dispersed in an ointment base was another control. The dorsal depilated skin surface was exposed to the whole UV range for 5\u2009sec, five times a week for 6 weeks. Each exposure was followed by treatment with encapsulated curcumin (at different doses), free curcumin ointment, and VICCO\n                    <jats:sup>\u00ae<\/jats:sup>\n                    turmeric. The effectiveness was established in terms of macroscopic and histopathological evaluation of skin, pinch test, and redox homeostasis of skin homogenates. Skin evaluation demonstrated that 5- and 10-\u03bcmol doses of curcumin EVs and the marketed formulation were effective in preventing the formation of lesions and other changes. The pinch test showed that the reduction in recovery time with the 10-\u03bcmol dose of curcumin EVs was highly significant (\n                    <jats:italic toggle=\"yes\">p<\/jats:italic>\n                    \u2009&lt;\u20090.05). Histopathological studies further confirmed the protective role of curcumin EVs. The normal redox balance was restored with a 10-\u03bcmol dose, whereas a 5-\u03bcmol dose and the marketed formulation showed significant and equivalent activity. The free curcumin ointment group showed no improvement in redox levels. This study provides the first preclinical evidence for the use of topically delivered curcumin to attenuate photoaging.\n                  <\/jats:p>","DOI":"10.1089\/rej.2009.0906","type":"journal-article","created":{"date-parts":[[2010,4,28]],"date-time":"2010-04-28T11:45:10Z","timestamp":1272455110000},"page":"397-410","source":"Crossref","is-referenced-by-count":43,"title":["Inhibitory Effect of Encapsulated Curcumin on Ultraviolet-Induced Photoaging in Mice"],"prefix":"10.1177","volume":"13","author":[{"given":"Rumjhum","family":"Agrawal","sequence":"first","affiliation":[{"name":"Panjab University","place":["India"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Indu Pal","family":"Kaur","sequence":"additional","affiliation":[{"name":"Panjab University","place":["India"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2010,8]]},"reference":[{"key":"e_1_3_1_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/0891-5849(96)00162-1"},{"key":"e_1_3_1_3_2","first-page":"168","volume-title":"Photodamage","author":"Gilchrest BA","year":"1995","unstructured":"Gilchrest BA. 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