{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T22:14:22Z","timestamp":1777932862623,"version":"3.51.4"},"reference-count":30,"publisher":"SAGE Publications","issue":"6","license":[{"start":{"date-parts":[[2011,12,1]],"date-time":"2011-12-01T00:00:00Z","timestamp":1322697600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Rejuvenation Research"],"published-print":{"date-parts":[[2011,12]]},"abstract":"<jats:p>\n                    Effects of stem and progenitor cells or their compounds on recipient cells are investigated intensively today. In spite of this, their ability to interact with native cells and the final targets affected by them, particularly biochemical parameters that characterize cell redox-dependent processes, remain little studied. We have studied how bioregulators of stem and progenitor cells affect these processes in freshly isolated liver after animal pretreatment\n                    <jats:italic toggle=\"yes\">in vivo<\/jats:italic>\n                    . Cytosol of human fetal mesenchymal\u2013mesodermal tissues (8\u201310 weeks gestation) was administered intravenously; the control group was treated with Hanks' solution. After 4\u2009hr, rats were sacrificed and their livers were isolated. To evaluate liver redox-dependent state, mitochondrial respiratory activity and nitroxyl radical and Alamar Blue\n                    <jats:sup>\u2122<\/jats:sup>\n                    reduction rates, mitochondrial and cytosolic glycerol kinase and nicotinamide adenine dinucleotide (NADH)-dependent malate dehydrogenase activities were studied. The results obtained demonstrate that bioregulators strongly affect liver redox-dependent processes, increasing mitochondrial respiration in state III and spin probe reduction rate and enhancing Alamar Blue\n                    <jats:sup>\u2122<\/jats:sup>\n                    reduction by glycolytic and nonglycolytic postmitochondrial enzymes. In addition, mitochondrial glycerol kinase and both isoforms of NADH-dependent malate dehydrogenase were inhibited. These data bring us closer to understanding stem and progenitor cell effects via directed regulation of metabolic redox-dependent processes.\n                  <\/jats:p>","DOI":"10.1089\/rej.2011.1168","type":"journal-article","created":{"date-parts":[[2011,10,18]],"date-time":"2011-10-18T16:22:17Z","timestamp":1318954937000},"page":"661-667","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":3,"title":["Capacity of Bioregulators of Stem and Progenitor Cells to Strongly Affect Liver Redox-Dependent Processes"],"prefix":"10.1177","volume":"14","author":[{"given":"Daria V.","family":"Cherkashina","sequence":"first","affiliation":[{"name":"Institute for Problems of Cryobiology and Cryomedicine of the National Academy of Sciences of Ukraine","place":["Ukraine"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elena N.","family":"Tkacheva","sequence":"additional","affiliation":[{"name":"Institute for Problems of Cryobiology and Cryomedicine of the National Academy of Sciences of Ukraine","place":["Ukraine"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alexander Y.","family":"Somov","sequence":"additional","affiliation":[{"name":"Institute for Problems of Cryobiology and Cryomedicine of the National Academy of Sciences of Ukraine","place":["Ukraine"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Olga A.","family":"Semenchenko","sequence":"additional","affiliation":[{"name":"Institute for Problems of Cryobiology and Cryomedicine of the National Academy of Sciences of Ukraine","place":["Ukraine"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Oleg A.","family":"Nardid","sequence":"additional","affiliation":[{"name":"Institute for Problems of Cryobiology and Cryomedicine of the National Academy of Sciences of Ukraine","place":["Ukraine"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alexander Y.","family":"Petrenko","sequence":"additional","affiliation":[{"name":"Institute for Problems of Cryobiology and Cryomedicine of the National Academy of Sciences of Ukraine","place":["Ukraine"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2011,12,1]]},"reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1007\/s10517-006-0216-y"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1089\/cpt.2005.3.201"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1440-1746.2007.05095.x"},{"key":"e_1_3_2_5_2","first-page":"108","article-title":"Modulating the state of the pro-oxidant-antioxidant brain system with xenopreparations under experimental chronic alcohol poisoning","volume":"6","author":"Kovalev GA","year":"2008","unstructured":"Kovalev GA, , Cherkashina DV. 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