{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T22:14:14Z","timestamp":1777932854246,"version":"3.51.4"},"reference-count":49,"publisher":"SAGE Publications","issue":"3","license":[{"start":{"date-parts":[[2012,6,1]],"date-time":"2012-06-01T00:00:00Z","timestamp":1338508800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Rejuvenation Research"],"published-print":{"date-parts":[[2012,6]]},"abstract":"<jats:p>\n                    Telomeres are specialized DNA structures located at the ends of chromosomes. Their length is reduced at each cell cycle, especially when the cumulative burden of oxidative stress is high. The purpose of this study was to determine the associations between telomere length and clinical and biological risk factors in ischemic stroke patients. A total of 215 stroke patients hospitalized in the Dijon, France, stroke unit were prospectively and continuously included from January to September, 2004. The telomere length measured from peripheral blood leukocytes\u2014leukocyte telomere length (LTL)\u2014was determined by real-time quantitative polymerase chain reaction. The results were compared with clinical and biological variables of interest collected at admission to find significant associations. Possible relationships between LTL and stroke subtypes were evaluated. A multiple regression that included all the variables significantly associated (\n                    <jats:italic toggle=\"yes\">p<\/jats:italic>\n                    &lt;0.20) with LTL in univariate analysis and age and subtypes of stroke confirmed a significant association with age (\n                    <jats:italic toggle=\"yes\">p<\/jats:italic>\n                    &lt;0.001), homocysteinemia (\n                    <jats:italic toggle=\"yes\">p<\/jats:italic>\n                    =0,049), and levels of both antiphospholipid antibodies (\n                    <jats:italic toggle=\"yes\">p<\/jats:italic>\n                    =0.019) and triglycerides (\n                    <jats:italic toggle=\"yes\">p<\/jats:italic>\n                    =0.007). Linearity was verified and confirmed for each variable. The subtype of stroke did not significantly affect telomere length. We were able to highlight significant associations between LTL and certain cerebrovascular risk factors in a general population of stroke patients. These associations did not depend on the ischemic stroke subtype.\n                  <\/jats:p>","DOI":"10.1089\/rej.2011.1243","type":"journal-article","created":{"date-parts":[[2012,4,24]],"date-time":"2012-04-24T19:17:49Z","timestamp":1335295069000},"page":"274-280","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":3,"title":["Leukocyte Telomere Length: A Focus on Cerebrovascular Events"],"prefix":"10.1177","volume":"15","author":[{"given":"Damien","family":"Biotti","sequence":"first","affiliation":[{"name":"University Hospital","place":["France"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Serge","family":"Aho","sequence":"additional","affiliation":[{"name":"H\u00f4pital Le Bocage","place":["France"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yannick","family":"B\u00e9jot","sequence":"additional","affiliation":[{"name":"University Hospital","place":["France"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maurice","family":"Giroud","sequence":"additional","affiliation":[{"name":"University Hospital","place":["France"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marie","family":"Caillier","sequence":"additional","affiliation":[{"name":"William Morey Hospital","place":["France"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sylviane","family":"Ragot","sequence":"additional","affiliation":[{"name":"University Hospital and Faculty of Medicine","place":["France"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Guy-Victor","family":"Osseby","sequence":"additional","affiliation":[{"name":"University Hospital","place":["France"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thibault","family":"Moreau","sequence":"additional","affiliation":[{"name":"University Hospital","place":["France"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jean-Raymond","family":"Teyssier","sequence":"additional","affiliation":[{"name":"University Hospital and Faculty of Medicine","place":["France"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2012,6]]},"reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.RES.0000251281.00845.18"},{"key":"e_1_3_3_3_2","doi-asserted-by":"crossref","first-page":"983","DOI":"10.1016\/S0140-6736(03)14369-3","article-title":"Telomere maintenance and disease","volume":"362","author":"Wong JM","year":"2003","unstructured":"Wong JM, , Collins K. 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