{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T22:14:01Z","timestamp":1777932841736,"version":"3.51.4"},"reference-count":21,"publisher":"SAGE Publications","issue":"2","license":[{"start":{"date-parts":[[2012,4,1]],"date-time":"2012-04-01T00:00:00Z","timestamp":1333238400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Rejuvenation Research"],"published-print":{"date-parts":[[2012,4]]},"abstract":"<jats:p>\n                    We tested a biofermented nutraceutical (FPP) that has been previously shown to positively modulate nitric oxide (NO). Forty-two healthy middle-aged subjects were given 3 grams of FPP three times a day for 6 weeks, and tests were repeated at 3 and 6 weeks; the control group was given a placebo. Flow-mediated dilation (FMD) was measured together with NO compounds (nitrogen oxides [NOx]: NO\n                    <jats:sub>2<\/jats:sub>\n                    <jats:sup>\u2212<\/jats:sup>\n                    +NO\n                    <jats:sub>3<\/jats:sub>\n                    <jats:sup>\u2212<\/jats:sup>\n                    ) plasma levels and asymmetrical dimethylarginine (ADMA). In the interventional group, overall FMD significantly increased from 4.2% to 7.3% (\n                    <jats:italic toggle=\"yes\">p<\/jats:italic>\n                    &lt;0.05 vs. placebo). A significant increase in plasma NO and a decrease in ADMA were detected after consumption of FPP (\n                    <jats:italic toggle=\"yes\">p<\/jats:italic>\n                    &lt;0.01). Although larger studies are awaited, it appears that, at least in healthy individuals, such nutraceutical intervention by positively acting on significant cardiovascular parameters can be considered in the armamentarium of a proactive age-management strategy.\n                  <\/jats:p>","DOI":"10.1089\/rej.2011.1276","type":"journal-article","created":{"date-parts":[[2012,4,25]],"date-time":"2012-04-25T14:21:18Z","timestamp":1335363678000},"page":"178-181","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":5,"title":["Cardioprotective Effect of a Biofermented Nutraceutical on Endothelial Function in Healthy Middle-Aged Subjects"],"prefix":"10.1177","volume":"15","author":[{"given":"Francesco","family":"Marotta","sequence":"first","affiliation":[{"name":"ReGenera Res Group for Aging Intervention","place":["Italy"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hariom","family":"Yadav","sequence":"additional","affiliation":[{"name":"National Institutes of Health"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Archana","family":"Kumari","sequence":"additional","affiliation":[{"name":"Universit\u00e9 du Qu\u00e9bec","place":["Canada"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Roberto","family":"Catanzaro","sequence":"additional","affiliation":[{"name":"University of Catania","place":["Italy"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shalini","family":"Jain","sequence":"additional","affiliation":[{"name":"National Institutes of Health"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ascanio","family":"Polimeni","sequence":"additional","affiliation":[{"name":"ReGenera Res Group for Aging Intervention","place":["Italy"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aldo","family":"Lorenzetti","sequence":"additional","affiliation":[{"name":"ReGenera Res Group for Aging Intervention","place":["Italy"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vincenzo","family":"Soresi","sequence":"additional","affiliation":[{"name":"Octopus Scientific Association of Bio-Prevention","place":["Italy"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2012,4,1]]},"reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1179\/acb.2006.036"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.101.9.948"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1464-5491.2011.03277.x"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.niox.2011.03.002"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0012461"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1089\/ars.2009.3039"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0024-3205(00)00664-0"},{"issue":"11","key":"e_1_3_2_9_2","first-page":"II","article-title":"Biology of the endothelium","volume":"20","author":"Luscher TF","year":"1997","unstructured":"Luscher TF, , Barton M. Biology of the endothelium. Clin Cardiol, 1997; 20,11 Suppl 2:II\u20133.","journal-title":"Clin Cardiol"},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0735-1097(01)01746-6"},{"key":"e_1_3_2_11_2","first-page":"28","article-title":"Plasma asymmetric dimethylarginine levels in healthy people","volume":"53","author":"Deneva-Koycheva TI","year":"2011","unstructured":"Deneva-Koycheva TI, , Vladimirova-Kitova LG, , Angelova EA, , Tsvetkova TZ. Plasma asymmetric dimethylarginine levels in healthy people. 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Circulation, 2004; 109,23 Suppl 1:III27\u2013III32.","journal-title":"Circulation"},{"key":"e_1_3_2_16_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.0000153349.77489.CF"},{"key":"e_1_3_2_17_2","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9149(95)80017-M"},{"key":"e_1_3_2_18_2","doi-asserted-by":"publisher","DOI":"10.1080\/003655102753517145"},{"key":"e_1_3_2_19_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.atherosclerosis.2011.06.021"},{"key":"e_1_3_2_20_2","doi-asserted-by":"publisher","DOI":"10.1161\/HYPERTENSIONAHA.110.168245"},{"key":"e_1_3_2_21_2","first-page":"231","article-title":"Oral administration of L-arginine in patients with angina or following myocardial infarction may be protective by increasing plasma superoxide dismutase and total thiols with reduction in serum cholesterol and xanthine oxidase","volume":"4","author":"Pratima T","year":"2009","unstructured":"Pratima T, , Chandra M, , Misra MK. Oral administration of L-arginine in patients with angina or following myocardial infarction may be protective by increasing plasma superoxide dismutase and total thiols with reduction in serum cholesterol and xanthine oxidase. Oxid Med Cell Longevity, 2009; 4:231\u2013237.","journal-title":"Oxid Med Cell Longevity"},{"key":"e_1_3_2_22_2","doi-asserted-by":"publisher","DOI":"10.1089\/rej.2006.9.227"}],"container-title":["Rejuvenation Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1089\/rej.2011.1276","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1089\/rej.2011.1276","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1089\/rej.2011.1276","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,2]],"date-time":"2026-05-02T01:31:13Z","timestamp":1777685473000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1089\/rej.2011.1276"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,4]]},"references-count":21,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2012,4]]}},"alternative-id":["10.1089\/rej.2011.1276"],"URL":"https:\/\/doi.org\/10.1089\/rej.2011.1276","relation":{},"ISSN":["1549-1684","1557-8577"],"issn-type":[{"value":"1549-1684","type":"print"},{"value":"1557-8577","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012,4]]}}}