{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,20]],"date-time":"2026-09-20T14:59:23Z","timestamp":1789916363193,"version":"4.0.1"},"reference-count":54,"publisher":"SAGE Publications","issue":"1","license":[{"start":{"date-parts":[[2013,2,1]],"date-time":"2013-02-01T00:00:00Z","timestamp":1359676800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Rejuvenation Research"],"published-print":{"date-parts":[[2013,2]]},"abstract":"<jats:p>\n                    Different factors interact to develop neurodegeneration in patients with dementia and other neurodegenerative disorders. Oxidative stress and the \u03b54 allele of apolipoprotein E (ApoE) are associated with significant alteration in lipid metabolism, in turn connected to a variety of neurodegenerative diseases and aging. Thus, a better understanding of the pathogenetic pathways associated with lipid dyshomeostasis may elucidate the causes of neurodegenerative processes. To address this issue, we evaluated the effects of antioxidant status and\n                    <jats:italic toggle=\"yes\">APOE<\/jats:italic>\n                    genotype on neurodegeneration in patients with dementia of the Alzheimer type (AD), with vascular dementia (VaD), and in elderly healthy controls. Eighty-two AD, 42 VaD patients, and 26 healthy controls were recruited and underwent medial temporal lobe atrophy (MTA) assessment, white matter hyperintensities rating (WMH), serum total antioxidant status assaying (TAS), and\n                    <jats:italic toggle=\"yes\">APOE<\/jats:italic>\n                    genotyping. A logistic regression algorithm applied to our data revealed that a 0.01\u2009mmol\/L decrease of TAS concentration increased the probability of MTA by 24% (\n                    <jats:italic toggle=\"yes\">p<\/jats:italic>\n                    =0.038) and that carriers of the\n                    <jats:italic toggle=\"yes\">APOE<\/jats:italic>\n                    \u03b54 allele showed higher WMH scores (\n                    <jats:italic toggle=\"yes\">p<\/jats:italic>\n                    =0.018), confirming that small variations in antioxidant systems homeostasis are associated with relevant modifications of disease risk. Furthermore, in individuals with analogous TAS values, the presence of the \u03b54 allele increased the predicted probability of having MTA. These outcomes further sustain the interaction of oxidative stress and\n                    <jats:italic toggle=\"yes\">APOE<\/jats:italic>\n                    genotype to neurodegeneration.\n                  <\/jats:p>","DOI":"10.1089\/rej.2012.1383","type":"journal-article","created":{"date-parts":[[2012,12,6]],"date-time":"2012-12-06T07:47:49Z","timestamp":1354780069000},"page":"51-56","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":21,"title":["Antioxidant Status and\n                    <i>APOE<\/i>\n                    Genotype As Susceptibility Factors for Neurodegeneration in Alzheimer's Disease and Vascular Dementia"],"prefix":"10.1177","volume":"16","author":[{"given":"Giancarlo","family":"Zito","sequence":"first","affiliation":[{"name":"Casa di Cura San Raffale Cassino & IRCCS San Raffale Pisana","place":["Italy"]},{"name":"Consiglio Nazionale delle 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