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In a recent interesting study, Hara and colleagues (J Neurosci 2012;32:7336\u20137344) tested young and aged monkeys on the visual recognition memory test \u201cdelayed nonmatching-to-sample\u201d (DNMS). Then they performed electron microscopy immunocytochemistry in the hippocampal DG to determine the subcellular localization of the GluA2 subunit of the glutamate \u03b1-amino-3-hydroxy-5-methyl-4-isoxazole-propionic acid receptor (AMPAR) and protein kinase M\u03b6 (PKM\u03b6), which promotes memory storage by regulating GluA2-containing AMPAR trafficking. The results obtained suggest that age-related deficits in visual recognition memory are coupled with impairment in PKM\u03b6-dependent maintenance of GluA2 at the synapse. Together with previous evidence of the critical role of PKM\u03b6 in memory consolidation, these data render this enzyme an attractive potential therapeutic target for preventing or treating age-related memory decline, and support the view that the pharmacological manipulation of AMPAR trafficking in the synapses may provide new insights in the search of memory enhancers for aged individuals, including those affected by Alzheimer disease.<\/jats:p>","DOI":"10.1089\/rej.2013.1448","type":"journal-article","created":{"date-parts":[[2013,5,16]],"date-time":"2013-05-16T11:23:56Z","timestamp":1368703436000},"page":"327-329","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":1,"title":["Protein Kinase M\u03b6-Dependent Maintenance of GluA2 at the Synapse: A Possible Target for Preventing or Treating Age-Related Memory Decline?"],"prefix":"10.1177","volume":"16","author":[{"given":"Giorgio","family":"Aicardi","sequence":"first","affiliation":[{"name":"University of Bologna","place":["Italy"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2013,8]]},"reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1002113107"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.0822-11.2011"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.tins.2011.02.004"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.conb.2011.12.006"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.0223-08.2008"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1038\/nn.2531"},{"key":"e_1_3_2_8_2","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1038\/nrn2949","article-title":"Sacktor TC How does PKM\u03b6 maintain long-term memory?","volume":"12","year":"2011","unstructured":"Sacktor TC How does PKM\u03b6 maintain long-term memory? 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