{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T22:15:02Z","timestamp":1777932902699,"version":"3.51.4"},"reference-count":18,"publisher":"SAGE Publications","issue":"4","license":[{"start":{"date-parts":[[2016,8,1]],"date-time":"2016-08-01T00:00:00Z","timestamp":1470009600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Rejuvenation Research"],"published-print":{"date-parts":[[2016,8]]},"abstract":"<jats:p>\n                    There is a growing interest in the potential of mesenchymal stem cells (MSCs) for implementing regenerative medicine. We assessed the effect of intravenous administration of human bone marrow-derived MSC on the life span of a single Sprague-Dawley female rat. The treatment was started when the rat was 6 months old and the cells were administered every 2 weeks afterward. The treatment did not induce any obvious changes in body growth or behavior and the rat showed the typical age changes for this strain, except that, unlike intact counterparts, the animal did not develop mammary tumors or pituitary gland hyperplasia. The more remarkable effect of the treatment was on life span, which was 44 months compared with an average of 36 months for intact laboratory rats. We conclude that despite the low\n                    <jats:italic toggle=\"yes\">N<\/jats:italic>\n                    value, it is likely that the MSC treatment was responsible for the exceptionally long survival of the rat. The potential rewards of confirming the present findings warrant further studies involving higher\n                    <jats:italic toggle=\"yes\">N<\/jats:italic>\n                    values.\n                  <\/jats:p>","DOI":"10.1089\/rej.2015.1777","type":"journal-article","created":{"date-parts":[[2015,12,9]],"date-time":"2015-12-09T21:43:29Z","timestamp":1449697409000},"page":"318-321","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":13,"title":["A Rat Treated with Mesenchymal Stem Cells Lives to 44 Months of Age"],"prefix":"10.1177","volume":"19","author":[{"given":"Eduardo","family":"Mansilla","sequence":"first","affiliation":[{"name":"Buenos Aires Province Ministry of Public Health","place":["Argentina"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gustavo","family":"Roque","sequence":"additional","affiliation":[{"name":"Buenos Aires Province Ministry of Public Health","place":["Argentina"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yolanda E.","family":"Sosa","sequence":"additional","affiliation":[{"name":"National University of La Plata","place":["Argentina"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Adrian","family":"Tarditti","sequence":"additional","affiliation":[{"name":"Buenos Aires Province Ministry of Public Health","place":["Argentina"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rodolfo G.","family":"Goya","sequence":"additional","affiliation":[{"name":"National University of La Plata","place":["Argentina"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2016,8]]},"reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1080\/14653240600855905"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2007-02-069716"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1136\/gut.2006.111617"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.1038\/gt.2010.10"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.284.5411.143"},{"key":"e_1_3_3_7_2","doi-asserted-by":"publisher","DOI":"10.1007\/s12015-015-9585-9"},{"key":"e_1_3_3_8_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0504388102"},{"key":"e_1_3_3_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.neulet.2010.06.045"},{"key":"e_1_3_3_10_2","doi-asserted-by":"crossref","DOI":"10.4061\/2011\/943216","article-title":"Could metabolic syndrome, lipodystrophy, and aging be mesenchymal stem cell exhaustion syndromes?","volume":"2011","author":"Mansilla E","year":"2011","unstructured":"Mansilla E, , D\u00edaz Aquino V, , Zamb\u00f3n D, , Marin GH, , M\u00e1rtire K, , Roque G, , Ichim T, , Riordan NH, , Patel A, , Sturla F, , Larsen G, , Spretz R, , N\u00fa\u00f1ez L, , Soratti C, , Ibar R, , van Leeuwen M, , Tau JM, , Drago H, , Maceira A. Could metabolic syndrome, lipodystrophy, and aging be mesenchymal stem cell exhaustion syndromes?. Stem Cells Int, 2011; 2011:943216.","journal-title":"Stem Cells Int"},{"key":"e_1_3_3_11_2","doi-asserted-by":"publisher","DOI":"10.1089\/rej.2015.1778"},{"key":"e_1_3_3_12_2","unstructured":"Normative values for rats Johns Hopkins University Animal Care and Use Committee. Available at: http:\/\/web.jhu.edu\/animalcare\/procedures\/rat.html#normative Accessed August28 2015."},{"key":"e_1_3_3_13_2","doi-asserted-by":"publisher","DOI":"10.1093\/jn\/10.1.63"},{"key":"e_1_3_3_14_2","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1016\/0197-4580(87)90006-6","article-title":"Rejuvenating effects of 10-week underfeeding period on estrous cycles in young and old rats","volume":"8","author":"Quigley KL","year":"1987","unstructured":"Quigley KL, , Goya RG, , Meites J. Rejuvenating effects of 10-week underfeeding period on estrous cycles in young and old rats. Neurobiol Aging, 1987; 8:225\u2013232.","journal-title":"Neurobiol Aging"},{"key":"e_1_3_3_15_2","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1016\/0047-6374(90)90116-W","article-title":"Gonadal function and pituitary and mammary pathology in the aging rat","volume":"56","author":"Goya RG","year":"1990","unstructured":"Goya RG, , Lu JKH, , Meites J. Gonadal function and pituitary and mammary pathology in the aging rat. Mech Age Devel, 1990; 56:77\u201388.","journal-title":"Mech Age Devel"},{"key":"e_1_3_3_16_2","doi-asserted-by":"crossref","first-page":"582","DOI":"10.1111\/j.2164-0947.1972.tb02712.x","article-title":"Mortality in syngeneic rat parabionts of different chronological age","volume":"34","author":"Ludwig FC","year":"1972","unstructured":"Ludwig FC, , Elashoff RM. Mortality in syngeneic rat parabionts of different chronological age. Trans New York Acad Sci, 1972; 34:582\u2013587.","journal-title":"Trans New York Acad Sci"},{"key":"e_1_3_3_17_2","doi-asserted-by":"publisher","DOI":"10.1038\/srep00067"},{"key":"e_1_3_3_18_2","doi-asserted-by":"publisher","DOI":"10.5966\/sctm.2015-0011"},{"key":"e_1_3_3_19_2","doi-asserted-by":"crossref","first-page":"659","DOI":"10.1038\/nm.3569","article-title":"Young blood reverses age-related impairments in cognitive function and synaptic plasticity in mice","volume":"20","author":"Villeda SA","year":"2014","unstructured":"Villeda SA, , Plambeck KE, , Middeldorp J, , Castellano JM, , Mosher KI, , Luo J, , Smith LK, , Bieri G, , Lin K, , Berdnik D, , Wabl R, , Udeochu J, , Wheatley EG, , Zou B, , Simmons DA, , Xie XS, , Longo FM, , Wyss-Coray T. Young blood reverses age-related impairments in cognitive function and synaptic plasticity in mice. Nature Med, 2014; 20:659\u2013663.","journal-title":"Nature Med"}],"container-title":["Rejuvenation Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1089\/rej.2015.1777","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1089\/rej.2015.1777","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1089\/rej.2015.1777","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,2]],"date-time":"2026-05-02T01:33:29Z","timestamp":1777685609000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/full\/10.1089\/rej.2015.1777"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,8]]},"references-count":18,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2016,8]]}},"alternative-id":["10.1089\/rej.2015.1777"],"URL":"https:\/\/doi.org\/10.1089\/rej.2015.1777","relation":{},"ISSN":["1549-1684","1557-8577"],"issn-type":[{"value":"1549-1684","type":"print"},{"value":"1557-8577","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,8]]}}}