{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,22]],"date-time":"2026-05-22T07:10:16Z","timestamp":1779433816644,"version":"3.53.1"},"reference-count":65,"publisher":"SAGE Publications","issue":"6","license":[{"start":{"date-parts":[[2016,12,1]],"date-time":"2016-12-01T00:00:00Z","timestamp":1480550400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Rejuvenation Research"],"published-print":{"date-parts":[[2016,12]]},"abstract":"<jats:p>\n                    A traditional herbal prescription Kyung-Ok-Ko (KOK), composed of\n                    <jats:italic toggle=\"yes\">Rehmannia glutinosa<\/jats:italic>\n                    Liboschitz var.\n                    <jats:italic toggle=\"yes\">purpurae<\/jats:italic>\n                    ,\n                    <jats:italic toggle=\"yes\">Lycium chinense<\/jats:italic>\n                    ,\n                    <jats:italic toggle=\"yes\">Aquilaria agallocha<\/jats:italic>\n                    ,\n                    <jats:italic toggle=\"yes\">Poria cocos<\/jats:italic>\n                    ,\n                    <jats:italic toggle=\"yes\">Panax ginseng<\/jats:italic>\n                    , and honey, has been widely used in Oriental medicine as an invigorant for age-related diseases, such as amnesia and stroke. However, the beneficial value of KOK on uterine dysfunction related to hyperandrogenism is largely unknown. We investigated the effect of KOK (2.0\u2009g\/kg\/day, per os) on endometrial abnormalities in a dehydroepiandrosterone (DHEA, subcutaneous)-induced polycystic ovary syndrome (PCOS) rat model. Preadministration of KOK significantly (\n                    <jats:italic toggle=\"yes\">p<\/jats:italic>\n                    &lt;0.05) decreased the elevated body weight, uterus weight, and endometrial thickness by PCOS induction, corresponding to reduced apoptosis and the infiltration of immune cells (CD4\n                    <jats:sup>+<\/jats:sup>\n                    T cells, CD8\n                    <jats:sup>+<\/jats:sup>\n                    T cells, and macrophages) in the endometrium. These results were associated with reduced mRNA expression of interleukin (IL)-1\u03b2, IL-6, IL-8, and matrix metalloproteinase-3 and increased mRNA expression of IGF-\u03b21, transforming growth factor (TGF)-\u03b2, TGF-\u03b21, and vascular endothelial growth factor in the uterus after DHEA injection. These multiple effects of KOK may synergistically prevent the development of endometrial abnormalities in DHEA-induced hyperandrogenism via anti-inflammatory action, indicating that KOK has preventive and therapeutic potential for suppressing PCOS.\n                  <\/jats:p>","DOI":"10.1089\/rej.2015.1787","type":"journal-article","created":{"date-parts":[[2016,2,22]],"date-time":"2016-02-22T05:02:44Z","timestamp":1456117364000},"page":"456-466","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":15,"title":["Effects of Oriental Medicine Kyung-Ok-Ko on Uterine Abnormality in Hyperandrogenized Rats"],"prefix":"10.1177","volume":"19","author":[{"given":"Min Jung","family":"Lee","sequence":"first","affiliation":[{"name":"College of Korean Medicine, Kyung Hee University"},{"name":"Kyung Hee University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Minhee","family":"Jang","sequence":"additional","affiliation":[{"name":"College of Korean Medicine, Kyung Hee University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chun-Sik","family":"Bae","sequence":"additional","affiliation":[{"name":"Chonnam National University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kyoung-Sun","family":"Park","sequence":"additional","affiliation":[{"name":"College of Korean Medicine, Kyung Hee University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hak-Jae","family":"Kim","sequence":"additional","affiliation":[{"name":"Soonchunhyang University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sanghyun","family":"Lee","sequence":"additional","affiliation":[{"name":"Chung-Ang University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sang Won","family":"Lee","sequence":"additional","affiliation":[{"name":"National Institute of Horticultural & Herbal Science"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Young Ock","family":"Kim","sequence":"additional","affiliation":[{"name":"National Institute of Horticultural & Herbal Science"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ik-Hyun","family":"Cho","sequence":"additional","affiliation":[{"name":"College of Korean Medicine, Kyung Hee University"},{"name":"Kyung Hee University"},{"name":"Kyung Hee University"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2016,12,1]]},"reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1177\/1933719111430993"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1210\/jcem.84.6.5803"},{"key":"e_1_3_3_4_2","first-page":"219","article-title":"Polycystic ovary syndrome: Etiology, pathogenesis and diagnosis","volume":"7","author":"Goodarzi MO","year":"2011","unstructured":"Goodarzi MO, , Dumesic DA, , Chazenbalk G, , Azziz R. Polycystic ovary syndrome: Etiology, pathogenesis and diagnosis. Nat Rev, 2011; 7:219\u2013231.","journal-title":"Nat Rev"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ygyno.2013.10.028"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.1093\/humrep\/des042"},{"key":"e_1_3_3_7_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa021423"},{"key":"e_1_3_3_8_2","doi-asserted-by":"publisher","DOI":"10.1097\/00000478-199909000-00014"},{"key":"e_1_3_3_9_2","doi-asserted-by":"publisher","DOI":"10.1097\/PGP.0b013e3181659167"},{"key":"e_1_3_3_10_2","doi-asserted-by":"publisher","DOI":"10.2147\/CLEP.S37559"},{"key":"e_1_3_3_11_2","doi-asserted-by":"publisher","DOI":"10.1093\/humupd\/dms040"},{"key":"e_1_3_3_12_2","first-page":"624","article-title":"The management of patients with polycystic ovary syndrome","volume":"10","author":"Jayasena CN","year":"2014","unstructured":"Jayasena CN, , Franks S. The management of patients with polycystic ovary syndrome. Nat Rev, 2014; 10:624\u2013636.","journal-title":"Nat Rev"},{"key":"e_1_3_3_13_2","first-page":"104","article-title":"Polycystic ovary syndrome: Current status and future perspective","volume":"6","author":"Barthelmess EK","year":"2014","unstructured":"Barthelmess EK, , Naz RK. Polycystic ovary syndrome: Current status and future perspective. Front Biosci (Elite Ed), 2014; 6:104\u2013119.","journal-title":"Front Biosci (Elite Ed)"},{"key":"e_1_3_3_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.rbmo.2009.06.008"},{"key":"e_1_3_3_15_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0015-0282(01)02963-6"},{"key":"e_1_3_3_16_2","doi-asserted-by":"publisher","DOI":"10.1093\/humupd\/3.4.359"},{"key":"e_1_3_3_17_2","first-page":"75","article-title":"Metformin and polycystic ovary syndrome","volume":"1","author":"Omran MY","year":"2007","unstructured":"Omran MY. Metformin and polycystic ovary syndrome. Int J Health Sci, 2007; 1:75\u201380.","journal-title":"Int J Health Sci"},{"key":"e_1_3_3_18_2","doi-asserted-by":"publisher","DOI":"10.1385\/ENDO:30:1:35"},{"key":"e_1_3_3_19_2","first-page":"2248","article-title":"Determinants of abnormal gonadotropin secretion in clinically defined women with polycystic ovary syndrome","volume":"82","author":"Taylor AE","year":"1997","unstructured":"Taylor AE, , McCourt B, , Martin KA, et al. Determinants of abnormal gonadotropin secretion in clinically defined women with polycystic ovary syndrome. J Clin Endocrinol Metab, 1997; 82:2248\u20132256.","journal-title":"J Clin Endocrinol Metab"},{"key":"e_1_3_3_20_2","doi-asserted-by":"publisher","DOI":"10.1152\/ajpendo.00667.2010"},{"key":"e_1_3_3_21_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0087623"},{"key":"e_1_3_3_22_2","unstructured":"Huh J. Donguibogam. Seoul: Namsandang Press 1610."},{"key":"e_1_3_3_23_2","first-page":"123","article-title":"An analysis of the gyungokgo's ingredients and a comparison study on anti-oxidation effects according to the kinds of extract","volume":"23","author":"Lee ES","year":"2008","unstructured":"Lee ES, , Shin YJ, , Park JH, , Kim SM, , Park CS. An analysis of the gyungokgo's ingredients and a comparison study on anti-oxidation effects according to the kinds of extract. Kor J Herb, 2008; 23:123\u2013136.","journal-title":"Kor J Herb"},{"key":"e_1_3_3_24_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jep.2010.04.009"},{"key":"e_1_3_3_25_2","first-page":"101","article-title":"Effects of kyungohkgo and prescription of modified kyungohkgo on lung cancer","volume":"17","author":"Lee ES","year":"2002","unstructured":"Lee ES, , Seo BI, , Lee JW, , Bae JS. Effects of kyungohkgo and prescription of modified kyungohkgo on lung cancer. Kor J Herb, 2002; 17:101\u2013109.","journal-title":"Kor J Herb"},{"key":"e_1_3_3_26_2","first-page":"35","article-title":"Ameliorating effect of a herbal medicinal prescription, Kyung-Ok-Ko, on scopolamine-induced memory impairment in mice","volume":"26","author":"Shin BY","year":"2009","unstructured":"Shin BY, , Lee YH, , Kim DH, , Park CS, , Lee YW, , Cho HJ, , Kim DH, , Yamamoto Y, , Kang DH, , Lee SJ, , Yoon BH, , Kim SH, , Ryu JH. Ameliorating effect of a herbal medicinal prescription, Kyung-Ok-Ko, on scopolamine-induced memory impairment in mice. J Tradit Med, 2009; 26:35\u201343.","journal-title":"J Tradit Med"},{"key":"e_1_3_3_27_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature11556"},{"key":"e_1_3_3_28_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jri.2004.04.002"},{"key":"e_1_3_3_29_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jep.2011.10.016"},{"key":"e_1_3_3_30_2","doi-asserted-by":"publisher","DOI":"10.1096\/fj.07-9574LSF"},{"key":"e_1_3_3_31_2","doi-asserted-by":"publisher","DOI":"10.1155\/2013\/237207"},{"key":"e_1_3_3_32_2","doi-asserted-by":"publisher","DOI":"10.1006\/meth.2001.1262"},{"key":"e_1_3_3_33_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jri.2011.09.003"},{"key":"e_1_3_3_34_2","doi-asserted-by":"publisher","DOI":"10.1210\/en.2007-0168"},{"key":"e_1_3_3_35_2","first-page":"273","article-title":"Effect of aloe barbadensis mill. formulation on Letrozole induced polycystic ovarian syndrome rat model","volume":"1","author":"Maharjan R","year":"2011","unstructured":"Maharjan R, , Nagar PS, , Nampoothiri L. Effect of aloe barbadensis mill. formulation on Letrozole induced polycystic ovarian syndrome rat model. J Ayurveda Integr Med, 2011; 1:273\u2013279.","journal-title":"J Ayurveda Integr Med"},{"key":"e_1_3_3_36_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejogrb.2006.01.023"},{"key":"e_1_3_3_37_2","doi-asserted-by":"publisher","DOI":"10.1093\/molehr\/gap033"},{"key":"e_1_3_3_38_2","doi-asserted-by":"publisher","DOI":"10.1189\/jlb.0712327"},{"key":"e_1_3_3_39_2","doi-asserted-by":"publisher","DOI":"10.1093\/humupd\/dmh011"},{"key":"e_1_3_3_40_2","doi-asserted-by":"publisher","DOI":"10.4110\/in.2015.15.1.16"},{"key":"e_1_3_3_41_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbi.2007.07.003"},{"key":"e_1_3_3_42_2","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2013-1923"},{"key":"e_1_3_3_43_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0015-0282(00)00711-1"},{"key":"e_1_3_3_44_2","first-page":"3765","article-title":"Cyclooxygenase-2 expression correlates with apoptosis and angiogenesis in endometrial cancer tissue","volume":"27","author":"Ohno S","year":"2007","unstructured":"Ohno S, , Ohno Y, , Suzuki N, , Soma G, , Inoue M. Cyclooxygenase-2 expression correlates with apoptosis and angiogenesis in endometrial cancer tissue. Anticancer Res, 2007; 27:3765\u20133770.","journal-title":"Anticancer Res"},{"key":"e_1_3_3_45_2","doi-asserted-by":"publisher","DOI":"10.1093\/humrep\/17.10.2573"},{"key":"e_1_3_3_46_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jsbmb.2010.02.015"},{"key":"e_1_3_3_47_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ygyno.2006.09.003"},{"key":"e_1_3_3_48_2","doi-asserted-by":"publisher","DOI":"10.1038\/ncponc0062"},{"key":"e_1_3_3_49_2","doi-asserted-by":"publisher","DOI":"10.1097\/00006254-199505000-00026"},{"key":"e_1_3_3_50_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1447-0756.2012.02036.x"},{"key":"e_1_3_3_51_2","doi-asserted-by":"publisher","DOI":"10.1093\/molehr\/gal057"},{"key":"e_1_3_3_52_2","doi-asserted-by":"publisher","DOI":"10.1530\/rep.1.00941"},{"key":"e_1_3_3_53_2","doi-asserted-by":"publisher","DOI":"10.1016\/0960-0760(92)90132-3"},{"key":"e_1_3_3_54_2","doi-asserted-by":"publisher","DOI":"10.1248\/bpb.17.1282"},{"key":"e_1_3_3_55_2","doi-asserted-by":"publisher","DOI":"10.1142\/S0192415X04002442"},{"key":"e_1_3_3_56_2","doi-asserted-by":"publisher","DOI":"10.3390\/molecules18055804"},{"key":"e_1_3_3_57_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jep.2015.06.026"},{"key":"e_1_3_3_58_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jep.2010.05.007"},{"key":"e_1_3_3_59_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejphar.2004.09.051"},{"key":"e_1_3_3_60_2","doi-asserted-by":"publisher","DOI":"10.1055\/s-0030-1270823"},{"key":"e_1_3_3_61_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jep.2012.02.048"},{"key":"e_1_3_3_62_2","doi-asserted-by":"publisher","DOI":"10.5142\/jgr.2012.36.4.342"},{"key":"e_1_3_3_63_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0006-2952(99)00212-9"},{"key":"e_1_3_3_64_2","doi-asserted-by":"publisher","DOI":"10.3390\/ijms15057827"},{"key":"e_1_3_3_65_2","doi-asserted-by":"publisher","DOI":"10.1248\/bpb.26.1574"},{"key":"e_1_3_3_66_2","doi-asserted-by":"publisher","DOI":"10.1007\/s12272-009-1306-y"}],"container-title":["Rejuvenation Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1089\/rej.2015.1787","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1089\/rej.2015.1787","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1089\/rej.2015.1787","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,22]],"date-time":"2026-05-22T07:02:05Z","timestamp":1779433325000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1089\/rej.2015.1787"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,12]]},"references-count":65,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2016,12]]}},"alternative-id":["10.1089\/rej.2015.1787"],"URL":"https:\/\/doi.org\/10.1089\/rej.2015.1787","relation":{},"ISSN":["1549-1684","1557-8577"],"issn-type":[{"value":"1549-1684","type":"print"},{"value":"1557-8577","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,12]]}}}