{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,12]],"date-time":"2026-06-12T17:09:08Z","timestamp":1781284148338,"version":"3.54.1"},"reference-count":46,"publisher":"SAGE Publications","issue":"1","license":[{"start":{"date-parts":[[2017,2,1]],"date-time":"2017-02-01T00:00:00Z","timestamp":1485907200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Rejuvenation Research"],"published-print":{"date-parts":[[2017,2]]},"abstract":"<jats:p>\n                    <jats:italic toggle=\"yes\">Epimedium<\/jats:italic>\n                    has been traditionally used to treat a variety of medical conditions, including neurological disorders. In this study, an acidic polysaccharide EbPS-A1 is isolated from\n                    <jats:italic toggle=\"yes\">Epimedium brevicornum<\/jats:italic>\n                    and found to contain mainly galacturonic acid, galactose, and rhamnose but also arabinose and glucuronic acid. Using\n                    <jats:italic toggle=\"yes\">Caenorhabditis elegans<\/jats:italic>\n                    models, we show that EbPS-A1 is capable of inhibiting behavioral dysfunction mediated by polyglutamine (polyQ), which is implicated in several neurodegenerative disorders such as Huntington's disease. Interestingly, EbPS-A1 does not inhibit polyQ aggregation or extend lifespan in the nematodes; it does, however, improve the survival under increased oxidative stress of both polyQ and wild-type nematodes intoxicated by paraquat. Further studies reveal that EbPS-A1 is capable of not only scavenging free radicals\n                    <jats:italic toggle=\"yes\">in vitro<\/jats:italic>\n                    but also reducing reactive oxygen species levels, enhancing antioxidant enzyme activities, and decreasing lipid peroxidation product in\n                    <jats:italic toggle=\"yes\">C. elegans<\/jats:italic>\n                    models. Together, these results suggest that the protective effect of\n                    <jats:italic toggle=\"yes\">Epimedium<\/jats:italic>\n                    polysaccharide against polyQ-mediated neurotoxicity is likely due to its antioxidant function.\n                  <\/jats:p>","DOI":"10.1089\/rej.2016.1830","type":"journal-article","created":{"date-parts":[[2016,5,24]],"date-time":"2016-05-24T23:00:08Z","timestamp":1464130808000},"page":"32-41","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":48,"title":["<i>Epimedium<\/i>\n                    Polysaccharide Alleviates Polyglutamine-Induced Neurotoxicity in\n                    <i>Caenorhabditis elegans<\/i>\n                    by Reducing Oxidative Stress"],"prefix":"10.1177","volume":"20","author":[{"given":"Yanxia","family":"Xiang","sequence":"first","affiliation":[{"name":"Wuhan University","place":["China"]},{"name":"Guangdong Pharmaceutical University","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ju","family":"Zhang","sequence":"additional","affiliation":[{"name":"Wuhan University","place":["China"]},{"name":"Guangdong Pharmaceutical University","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haifeng","family":"Li","sequence":"additional","affiliation":[{"name":"Wuhan University","place":["China"]},{"name":"Guangdong Pharmaceutical University","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qiangqiang","family":"Wang","sequence":"additional","affiliation":[{"name":"Wuhan University","place":["China"]},{"name":"Research & Development Center","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lingyun","family":"Xiao","sequence":"additional","affiliation":[{"name":"Wuhan University","place":["China"]},{"name":"Research & Development Center","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huandi","family":"Weng","sequence":"additional","affiliation":[{"name":"Guangdong Pharmaceutical University","place":["China"]},{"name":"Guangdong Pharmaceutical University","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaobin","family":"Zhou","sequence":"additional","affiliation":[{"name":"Guangdong Pharmaceutical University","place":["China"]},{"name":"Guangdong Pharmaceutical University","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chung Wah","family":"Ma","sequence":"additional","affiliation":[{"name":"Research & Development Center","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fangli","family":"Ma","sequence":"additional","affiliation":[{"name":"Research & Development Center","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Minghua","family":"Hu","sequence":"additional","affiliation":[{"name":"Research & Development Center","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zebo","family":"Huang","sequence":"additional","affiliation":[{"name":"Wuhan University","place":["China"]},{"name":"Guangdong Pharmaceutical University","place":["China"]},{"name":"Guangdong Pharmaceutical University","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2017,2,1]]},"reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0028835"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jep.2015.11.007"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.carbpol.2015.11.014"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.1111\/cpr.12147"},{"key":"e_1_3_3_6_2","doi-asserted-by":"crossref","unstructured":"Shindel AW Xin ZC Lin G Fandel TM Huang YC Banie L Breyer BN Garcia MM. 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