{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T07:40:26Z","timestamp":1790322026673,"version":"4.1.0"},"reference-count":52,"publisher":"SAGE Publications","issue":"3","license":[{"start":{"date-parts":[[2018,6,1]],"date-time":"2018-06-01T00:00:00Z","timestamp":1527811200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Rejuvenation Research"],"published-print":{"date-parts":[[2018,6]]},"abstract":"<jats:p>\n                    The association between diabetes and dementia has been well demonstrated by epidemiologic studies. Berberine (BBR) has been reported to ameliorate diabetes and diabetic encephalopathy (DE). However, the mechanism is still unknown. In this study, we employ a diabetic model,\n                    <jats:italic toggle=\"yes\">db\/db<\/jats:italic>\n                    mice, to explore whether BBR could protect DE through the SIRT1\/endoplasmic reticulum (ER) stress pathway. Behavioral results (Morris water maze, Y-maze spontaneous alternation test, and fear conditioning test) showed that oral administration of BBR (50\u2009mg\/kg) improved the learning and memory ability. Furthermore, BBR promoted lipid metabolism and decreased fasting glucose in\n                    <jats:italic toggle=\"yes\">db\/db<\/jats:italic>\n                    mice. Moreover, western blot analysis revealed that BBR increased the synapse- and nerve-related protein expression (PSD95, SYN, and NGF) and decreased the protein expression of inflammatory factors (TNF-\u03b1 and NF-\u03baB) in the hippocampus of\n                    <jats:italic toggle=\"yes\">db\/db<\/jats:italic>\n                    mice. BBR also increased the protein expression of SIRT1 and downregulated ER stress-associated proteins (PERK, IRE-1\u03b1, eIF-2\u03b1, PDI, and CHOP) in the hippocampus of\n                    <jats:italic toggle=\"yes\">db\/db<\/jats:italic>\n                    mice. Taken together, the present results suggest that the SIRT1\/ER stress pathway might be a crucial mechanism in the neuroprotective effect of BBR against DE.\n                  <\/jats:p>","DOI":"10.1089\/rej.2017.1972","type":"journal-article","created":{"date-parts":[[2017,8,7]],"date-time":"2017-08-07T06:00:44Z","timestamp":1502085644000},"page":"200-209","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":64,"title":["Berberine Improves Diabetic Encephalopathy Through the SIRT1\/ER Stress Pathway in\n                    <i>db\/db<\/i>\n                    Mice"],"prefix":"10.1177","volume":"21","author":[{"given":"Hong-Ying","family":"Li","sequence":"first","affiliation":[{"name":"Guangzhou University of Chinese Medicine","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xin-Chen","family":"Wang","sequence":"additional","affiliation":[{"name":"Guangzhou University of Chinese Medicine","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu-Min","family":"Xu","sequence":"additional","affiliation":[{"name":"Guangzhou University of Chinese Medicine","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Na-Chuan","family":"Luo","sequence":"additional","affiliation":[{"name":"Guangzhou University of Chinese Medicine","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Si","family":"Luo","sequence":"additional","affiliation":[{"name":"Guangzhou University of Chinese Medicine","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xu-Yi","family":"Hao","sequence":"additional","affiliation":[{"name":"Guangzhou University of Chinese Medicine","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shu-Yi","family":"Cheng","sequence":"additional","affiliation":[{"name":"Guangzhou University of Chinese Medicine","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jian-Song","family":"Fang","sequence":"additional","affiliation":[{"name":"Guangzhou University of Chinese Medicine","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qi","family":"Wang","sequence":"additional","affiliation":[{"name":"Guangzhou University of Chinese Medicine","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shi-Jie","family":"Zhang","sequence":"additional","affiliation":[{"name":"Guangzhou University of Chinese Medicine","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yun-Bo","family":"Chen","sequence":"additional","affiliation":[{"name":"Guangzhou University of Chinese Medicine","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2018,6]]},"reference":[{"key":"e_1_3_4_2_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.56.1.42"},{"key":"e_1_3_4_3_2","doi-asserted-by":"publisher","DOI":"10.2337\/dc08-1657"},{"key":"e_1_3_4_4_2","doi-asserted-by":"publisher","DOI":"10.2337\/dc09-1923"},{"key":"e_1_3_4_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.pbb.2013.10.021"},{"key":"e_1_3_4_6_2","doi-asserted-by":"publisher","DOI":"10.1186\/1475-2840-11-119"},{"key":"e_1_3_4_7_2","doi-asserted-by":"publisher","DOI":"10.1002\/dmrr.196"},{"key":"e_1_3_4_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuint.2005.12.009"},{"key":"e_1_3_4_9_2","doi-asserted-by":"publisher","DOI":"10.2337\/diab.46.2.S19"},{"key":"e_1_3_4_10_2","doi-asserted-by":"publisher","DOI":"10.1007\/s007020050067"},{"key":"e_1_3_4_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0014-2999(02)01486-3"},{"key":"e_1_3_4_12_2","doi-asserted-by":"publisher","DOI":"10.1002\/ptr.2968"},{"key":"e_1_3_4_13_2","doi-asserted-by":"publisher","DOI":"10.1152\/ajpendo.90599.2008"},{"key":"e_1_3_4_14_2","first-page":"3777","article-title":"Berberine inhibits human neuroblastoma cell growth through induction of p53-dependent apoptosis","volume":"28","author":"Choi MS","year":"2008","unstructured":"Choi MS, , Yuk DY, , Oh JH, , Jung HY, , Han SB, , Moon DC, , Hong JT. 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