{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,9]],"date-time":"2026-09-09T20:50:56Z","timestamp":1788987056740,"version":"build-2803163510"},"reference-count":30,"publisher":"SAGE Publications","issue":"6","license":[{"start":{"date-parts":[[2019,12,1]],"date-time":"2019-12-01T00:00:00Z","timestamp":1575158400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Rejuvenation Research"],"published-print":{"date-parts":[[2019,12]]},"abstract":"<jats:p>\n                    The \u03b1-Klotho gene was identified as a possible \u201caging-suppressor\u201d agent that extends life span when overexpressed. However, little is known about the association of the body composition with the secreted protein form of the \u03b1-Klotho gene (S-Klotho). Therefore, the aim of this study was to analyze the association of body composition, including lean and fat mass as well as bone mineral density (BMD), with S-Klotho plasma levels in middle-aged sedentary adults. A total of 74 (39 women) middle-aged sedentary adults (53.7\u2009\u00b1\u20095.1 years old; 75.7\u2009\u00b1\u200914.0\u2009kg; 167.8\u2009\u00b1\u20099.8\u2009cm) participated in the study. We measured weight and height, and we used dual-energy X-ray absorptiometry to measure fat mass and lean mass. We calculated the body mass index (BMI), fat mass index (FMI), and lean mass index (LMI). The S-Klotho plasma levels were measured in the ethylenediaminetetraacetic acid plasma using a solid-phase sandwich enzyme-linked immunosorbent assay. There was a strong positive association between LMI and S-Klotho plasma levels (\n                    <jats:italic toggle=\"yes\">\u03b2<\/jats:italic>\n                    \u2009=\u200974.794,\n                    <jats:italic toggle=\"yes\">R<\/jats:italic>\n                    <jats:sup>2<\/jats:sup>\n                    \u2009=\u20090.346,\n                    <jats:italic toggle=\"yes\">p<\/jats:italic>\n                    \u2009&lt;\u20090.001), which persisted after controlling for age and gender as well as after additionally controlling for FMI. Significantly positive associations of BMI and BMD were also found with S-Klotho plasma levels (\n                    <jats:italic toggle=\"yes\">\u03b2<\/jats:italic>\n                    \u2009=\u200933.981,\n                    <jats:italic toggle=\"yes\">R<\/jats:italic>\n                    <jats:sup>2<\/jats:sup>\n                    \u2009=\u20090.125,\n                    <jats:italic toggle=\"yes\">p<\/jats:italic>\n                    \u2009=\u20090.002 and\n                    <jats:italic toggle=\"yes\">\u03b2<\/jats:italic>\n                    \u2009=\u2009858.194,\n                    <jats:italic toggle=\"yes\">R<\/jats:italic>\n                    <jats:sup>2<\/jats:sup>\n                    \u2009=\u20090.058,\n                    <jats:italic toggle=\"yes\">p<\/jats:italic>\n                    \u2009=\u20090.041, respectively), which disappeared after controlling for LMI (\n                    <jats:italic toggle=\"yes\">\u03b2<\/jats:italic>\n                    \u2009=\u20090.183,\n                    <jats:italic toggle=\"yes\">R<\/jats:italic>\n                    <jats:sup>2<\/jats:sup>\n                    \u2009=\u20090.611,\n                    <jats:italic toggle=\"yes\">p<\/jats:italic>\n                    \u2009=\u20090.984 and\n                    <jats:italic toggle=\"yes\">\u03b2<\/jats:italic>\n                    \u2009=\u2009\u2212379.426,\n                    <jats:italic toggle=\"yes\">R<\/jats:italic>\n                    <jats:sup>2<\/jats:sup>\n                    \u2009=\u20090.617,\n                    <jats:italic toggle=\"yes\">p<\/jats:italic>\n                    \u2009=\u20090.290, respectively). FMI was not significantly associated with S-Klotho plasma levels. Our study shows that LMI is strongly associated with S-Klotho plasma levels and explains the associations of BMI and BMD with S-Klotho plasma levels in middle-aged sedentary adults.\n                  <\/jats:p>","DOI":"10.1089\/rej.2018.2092","type":"journal-article","created":{"date-parts":[[2019,1,23]],"date-time":"2019-01-23T06:52:15Z","timestamp":1548226335000},"page":"478-483","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":37,"title":["Body Composition and S-Klotho Plasma Levels in Middle-Aged Adults: A Cross-Sectional Study"],"prefix":"10.1177","volume":"22","author":[{"given":"Francisco J.","family":"Amaro-Gahete","sequence":"first","affiliation":[{"name":"EFFECTS-262 Research Group, Department of Physiology, School of Medicine, University of Granada, Granada, Spain."},{"name":"PROmoting FITness and Health Through Physical Activity Research Group (PROFITH), Department of Physical Education and Sports, Faculty of Sport Sciences, University of Granada, Granada, Spain."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alejandro","family":"De-la-O","sequence":"additional","affiliation":[{"name":"EFFECTS-262 Research Group, Department of Physiology, School of Medicine, University of Granada, Granada, Spain."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lucas","family":"Jurado-Fasoli","sequence":"additional","affiliation":[{"name":"EFFECTS-262 Research Group, Department of Physiology, School of Medicine, University of Granada, Granada, Spain."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrea","family":"Espuch-Oliver","sequence":"additional","affiliation":[{"name":"Clinical Laboratory Service, \u201cVirgen de las Nieves\u201d University Hospital, Granada, Spain."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tom\u00e1s","family":"de Haro","sequence":"additional","affiliation":[{"name":"Clinical Laboratory Service, \u201cSan Cecilio\u201d University Hospital, Granada, Spain."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"\u00c1ngel","family":"Guti\u00e9rrez","sequence":"additional","affiliation":[{"name":"EFFECTS-262 Research Group, Department of Physiology, School of Medicine, University of Granada, Granada, Spain."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jonatan R.","family":"Ruiz","sequence":"additional","affiliation":[{"name":"PROmoting FITness and Health Through Physical Activity Research Group (PROFITH), Department of Physical Education and Sports, Faculty of Sport Sciences, University of Granada, Granada, Spain."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manuel J.","family":"Castillo","sequence":"additional","affiliation":[{"name":"EFFECTS-262 Research Group, Department of Physiology, School of Medicine, University of Granada, Granada, Spain."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2019,12,13]]},"reference":[{"key":"e_1_3_5_2_2","doi-asserted-by":"publisher","DOI":"10.1038\/36285"},{"key":"e_1_3_5_3_2","doi-asserted-by":"publisher","DOI":"10.1177\/0300060517718452"},{"key":"e_1_3_5_4_2","doi-asserted-by":"publisher","DOI":"10.3389\/fgene.2018.00015"},{"key":"e_1_3_5_5_2","doi-asserted-by":"publisher","DOI":"10.1007\/s12020-013-9992-0"},{"key":"e_1_3_5_6_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00198-017-4151-8"},{"key":"e_1_3_5_7_2","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2017.01745"},{"key":"e_1_3_5_8_2","doi-asserted-by":"publisher","DOI":"10.3389\/fendo.2017.00046"},{"key":"e_1_3_5_9_2","doi-asserted-by":"publisher","DOI":"10.3945\/ajcn.117.152488"},{"key":"e_1_3_5_10_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00424-009-0722-7"},{"key":"e_1_3_5_11_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI5705"},{"key":"e_1_3_5_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.febslet.2004.03.090"},{"key":"e_1_3_5_13_2","doi-asserted-by":"publisher","DOI":"10.15280\/jlm.2015.5.1.1"},{"key":"e_1_3_5_14_2","first-page":"1","article-title":"The effects of aerobic and anaerobic exercises on circulating soluble-Klotho and IGF-I in young and elderly adults and in CAD patients","volume":"6","author":"Saghiv MS","year":"2017","unstructured":"Saghiv MS, , Sira D Ben, , Goldhammer E, et al. The effects of aerobic and anaerobic exercises on circulating soluble-Klotho and IGF-I in young and elderly adults and in CAD patients. 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