{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,13]],"date-time":"2026-05-13T16:37:02Z","timestamp":1778690222770,"version":"3.51.4"},"reference-count":37,"publisher":"SAGE Publications","issue":"4","license":[{"start":{"date-parts":[[2019,8,1]],"date-time":"2019-08-01T00:00:00Z","timestamp":1564617600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Rejuvenation Research"],"published-print":{"date-parts":[[2019,8]]},"abstract":"<jats:p>\n                    Liver cells are easily damaged by oxidative stress during progression both in liver development and throughout adult life, resulting in tissue pathology that ranges from simple hepatitis to nonalcoholic fatty liver disease. In this study, we determined the attenuation of oxidative stress in liver cells with pretreatment of rosmarinic acid (RA), which is an antioxidant agent from\n                    <jats:italic toggle=\"yes\">Rosmarinus officinalis<\/jats:italic>\n                    . The human liver cell line L02 was damaged by hydrogen peroxide (H\n                    <jats:sub>2<\/jats:sub>\n                    O\n                    <jats:sub>2<\/jats:sub>\n                    ). In the RA treatment group, the viability of L02 cells increased and the intracellular reactive oxygen species levels decreased compared with the H\n                    <jats:sub>2<\/jats:sub>\n                    O\n                    <jats:sub>2<\/jats:sub>\n                    -induced damage group. Analysis of flow cytometry revealed that the percentage of G2\/M cell cycle arrest and cell apoptosis decreased in the RA treatment group. This alteration was associated with activation of a G2\/M DNA damage and oxidative stress apoptotic signal. Furthermore, we determined the redox-sensitive protein expression of mitogen-activated protein kinases (MAPKs), quinone acceptor oxidoreductase 1 (NQO1), and nuclear factor E2-related factor 2 (Nrf2), and the expression of both MAPKs and Nrf2 was activated in the RA group. Results showed that the relevant protein expression of MAPKs and Nrf2 was activated in the RA group. Thus, RA protected L02 cells from oxidative damage through suppressing cell cycle arrest and cell apoptosis with the activation of MAPK and Nrf2 signaling pathways.\n                  <\/jats:p>","DOI":"10.1089\/rej.2018.2107","type":"journal-article","created":{"date-parts":[[2018,10,31]],"date-time":"2018-10-31T08:57:13Z","timestamp":1540976233000},"page":"289-298","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":42,"title":["Rosmarinic Acid Ameliorates H\n                    <sub>2<\/sub>\n                    O\n                    <sub>2<\/sub>\n                    -Induced Oxidative Stress in L02 Cells Through MAPK and Nrf2 Pathways"],"prefix":"10.1177","volume":"22","author":[{"given":"Yahui","family":"Ding","sequence":"first","affiliation":[{"name":"School of Biosciences &amp; Biopharmaceutics and Center for Bioresources &amp; Drug Discovery, Guangdong Pharmaceutical University, Guangzhou, China."},{"name":"School of Pharmacy, Guangdong Pharmaceutical University, Guangzhou, China."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhiyang","family":"Zhang","sequence":"additional","affiliation":[{"name":"School of Biosciences &amp; Biopharmaceutics and Center for Bioresources &amp; Drug Discovery, Guangdong Pharmaceutical University, Guangzhou, China."},{"name":"School of Pharmacy, Guangdong Pharmaceutical University, Guangzhou, China."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhongbao","family":"Yue","sequence":"additional","affiliation":[{"name":"Research and Development Centre, Infinitus (China) Company Ltd., Guangzhou, China."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Liugang","family":"Ding","sequence":"additional","affiliation":[{"name":"Research and Development Centre, Infinitus (China) Company Ltd., Guangzhou, China."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yong","family":"Zhou","sequence":"additional","affiliation":[{"name":"Research and Development Centre, Infinitus (China) Company Ltd., Guangzhou, China."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zebo","family":"Huang","sequence":"additional","affiliation":[{"name":"School of Biosciences &amp; Biopharmaceutics and Center for Bioresources &amp; Drug Discovery, Guangdong Pharmaceutical University, Guangzhou, China."},{"name":"School of Food Science and Engineering, South China University of Technology, Guangzhou, China."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hongliang","family":"Huang","sequence":"additional","affiliation":[{"name":"School of Biosciences &amp; Biopharmaceutics and Center for Bioresources &amp; Drug Discovery, Guangdong Pharmaceutical University, Guangzhou, China."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2019,8,16]]},"reference":[{"key":"e_1_3_4_2_2","doi-asserted-by":"publisher","DOI":"10.1002\/j.2040-4603.2013.tb00507.x"},{"key":"e_1_3_4_3_2","doi-asserted-by":"publisher","DOI":"10.3390\/ijms17060947"},{"key":"e_1_3_4_4_2","doi-asserted-by":"publisher","DOI":"10.3390\/ijms17050774"},{"key":"e_1_3_4_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.metabol.2015.05.002"},{"key":"e_1_3_4_6_2","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v20.i36.12956"},{"key":"e_1_3_4_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2012.05.019"},{"key":"e_1_3_4_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cub.2014.03.034"},{"key":"e_1_3_4_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmet.2015.04.004"},{"key":"e_1_3_4_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.carbpol.2013.12.061"},{"key":"e_1_3_4_11_2","doi-asserted-by":"publisher","DOI":"10.1021\/jf904549s"},{"key":"e_1_3_4_12_2","doi-asserted-by":"publisher","DOI":"10.1038\/srep41854"},{"key":"e_1_3_4_13_2","doi-asserted-by":"publisher","DOI":"10.1038\/srep34064"},{"key":"e_1_3_4_14_2","doi-asserted-by":"publisher","DOI":"10.2119\/molmed.2013.00027"},{"key":"e_1_3_4_15_2","first-page":"1799","article-title":"Therapeutic and nutraceutical potential of rosmarinic acid\u2014Cytoprotective properties and pharmacokinetic profile","volume":"19","author":"Nunes S","year":"2015","unstructured":"Nunes S, , Madureira AR, , Campos D, et al. 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