{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T22:15:35Z","timestamp":1777932935051,"version":"3.51.4"},"reference-count":48,"publisher":"SAGE Publications","issue":"3","license":[{"start":{"date-parts":[[2020,6,1]],"date-time":"2020-06-01T00:00:00Z","timestamp":1590969600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Rejuvenation Research"],"published-print":{"date-parts":[[2020,6]]},"abstract":"<jats:p>\n                    Although depression is the most common psychiatric disorder, its pharmacological properties are not well known yet. It has been reported that\n                    <jats:italic toggle=\"yes\">Valeriana fauriei<\/jats:italic>\n                    (VF) extract is beneficial for several neurological diseases. However, little information is available regarding its antidepressant activity. Therefore, the objective of this study was to determine antidepressant activity of VF and the underlying mechanism involved in its effect on chronic restraint stress (CRS)-induced depression using a mouse model. Oral treatment of VF extract for 14 days significantly ameliorated depression-like behavior (immobility time) in forced swimming and tail suspension tests following CRS induction, in accordance with decreased levels of serum corticosterone. VF extract ameliorated c-Fos expression, microglial activation, phosphorylated p38 expression, and inflammatory response (protein expression levels of cyclooxygenase-2 and inducible nitric oxide) in the prefrontal cortex, hippocampus, and amygdala of mice after CRS induction. However, VF extract enhanced the stimulation of nuclear factor erythroid 2-related factor 2 pathways, in accordance with upregulation in protein expression of brain-derived neurotrophic factor (BDNF). Collectively, our findings demonstrate that VF extract has antidepressant-like activity against CRS-induced depression through its anti-inflammatory and antioxidant effects by inhibiting BDNF expression. Further studies are warranted to investigate VF extract's fraction and components to develop possible antidepressants.\n                  <\/jats:p>","DOI":"10.1089\/rej.2018.2157","type":"journal-article","created":{"date-parts":[[2019,8,27]],"date-time":"2019-08-27T06:47:30Z","timestamp":1566888450000},"page":"245-255","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":13,"title":["<i>Valeriana fauriei<\/i>\n                    Exerts Antidepressant-Like Effects Through Anti-inflammatory and Antioxidant Activities by Inhibiting Brain-Derived Neurotrophic Factor Associated with Chronic Restraint Stress"],"prefix":"10.1177","volume":"23","author":[{"given":"Jong Hee","family":"Choi","sequence":"first","affiliation":[{"name":"Brain Korea 21 Plus Program, Department of Science in Korean Medicine, Graduate School, Kyung Hee University, Seoul, Republic of Korea."},{"name":"Department of Convergence Medical Science, College of Korean Medicine, Kyung Hee University, Seoul, Republic of Korea."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Min Jung","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Convergence Medical Science, College of Korean Medicine, Kyung Hee University, Seoul, Republic of Korea."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yeeun","family":"Chang","sequence":"additional","affiliation":[{"name":"Brain Korea 21 Plus Program, Department of Science in Korean Medicine, Graduate School, Kyung Hee University, Seoul, Republic of Korea."},{"name":"Department of Convergence Medical Science, College of Korean Medicine, Kyung Hee University, Seoul, Republic of Korea."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sanghyun","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Plant Science and Technology, Chung-Ang University, Anseong, Republic of Korea."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hak-Jae","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Clinical Pharmacology, College of Medicine, Soonchunhyang University, Cheonan, Republic of Korea."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sang Won","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Medicinal Crop Research Institute, National Institute of Horticultural &amp; Herbal Science, Rural Development Administration, Eumseong, Republic of Korea."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Young Ock","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Medicinal Crop Research Institute, National Institute of Horticultural &amp; Herbal Science, Rural Development Administration, Eumseong, Republic of Korea."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ik-Hyun","family":"Cho","sequence":"additional","affiliation":[{"name":"Brain Korea 21 Plus Program, Department of Science in Korean Medicine, Graduate School, Kyung Hee University, Seoul, Republic of Korea."},{"name":"Department of Convergence Medical Science, College of Korean Medicine, Kyung Hee University, Seoul, Republic of Korea."},{"name":"Institute of Korean Medicine, College of Korean Medicine, Kyung Hee University, Seoul, Republic of Korea."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2020,6,16]]},"reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1159\/000350094"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature07455"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1111\/imm.12443"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2014.10.037"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0705615105"},{"key":"e_1_3_3_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.nurx.2005.12.007"},{"issue":"6","key":"e_1_3_3_8_2","first-page":"16","article-title":"Treatment-resistant depression","volume":"67","author":"Souery D","year":"2006","unstructured":"Souery D, , Papakostas GI, , Trivedi MH. Treatment-resistant depression. J Clin Psychiatry, 2006; 67(Suppl 6):16\u201322.","journal-title":"J Clin Psychiatry"},{"key":"e_1_3_3_9_2","doi-asserted-by":"publisher","DOI":"10.1007\/s11064-005-6967-4"},{"key":"e_1_3_3_10_2","first-page":"127","article-title":"New drug targets in depression: Inflammatory, cell-mediated immune, oxidative and nitrosative stress, mitochondrial, antioxidant, and neuroprogressive pathways","volume":"20","author":"Maes M","year":"2012","unstructured":"Maes M, , Fisar Z, , Medina M, et al. New drug targets in depression: Inflammatory, cell-mediated immune, oxidative and nitrosative stress, mitochondrial, antioxidant, and neuroprogressive pathways. And new drug candidates\u2014Nrf2 activators and GSK-3 inhibitors. Inflammopharmacology, 2012; 20:127\u2013150.","journal-title":"And new drug candidates\u2014Nrf2 activators and GSK-3 inhibitors. Inflammopharmacology"},{"key":"e_1_3_3_11_2","doi-asserted-by":"publisher","DOI":"10.1038\/srep30659"},{"key":"e_1_3_3_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.psyneuen.2016.11.031"},{"key":"e_1_3_3_13_2","doi-asserted-by":"publisher","DOI":"10.1111\/bph.13426"},{"key":"e_1_3_3_14_2","doi-asserted-by":"publisher","DOI":"10.1196\/annals.1403.009"},{"key":"e_1_3_3_15_2","first-page":"287","article-title":"The cytokine hypothesis of depression: Inflammation, oxidative & nitrosative stress (IO&NS) and leaky gut as new targets for adjunctive treatments in depression","volume":"29","author":"Maes M","year":"2008","unstructured":"Maes M. The cytokine hypothesis of depression: Inflammation, oxidative & nitrosative stress (IO&NS) and leaky gut as new targets for adjunctive treatments in depression. Neuro Endocrinol Lett, 2008; 29:287\u2013291.","journal-title":"Neuro Endocrinol Lett"},{"key":"e_1_3_3_16_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.psyneuen.2013.03.020"},{"key":"e_1_3_3_17_2","doi-asserted-by":"publisher","DOI":"10.1248\/cpb.43.169"},{"key":"e_1_3_3_18_2","first-page":"6","article-title":"A comprehensive pharmacognotic report on valerian","volume":"1","author":"Sharma M","year":"2010","unstructured":"Sharma M, , Jain UK, , Patel A, et al. A comprehensive pharmacognotic report on valerian. Int J Pharm Sci Res, 2010; 1:6\u201340.","journal-title":"Int J Pharm Sci Res"},{"key":"e_1_3_3_19_2","doi-asserted-by":"publisher","DOI":"10.1055\/s-2006-957392"},{"key":"e_1_3_3_20_2","doi-asserted-by":"publisher","DOI":"10.1002\/hlca.201200247"},{"key":"e_1_3_3_21_2","doi-asserted-by":"publisher","DOI":"10.1055\/s-2005-916210"},{"key":"e_1_3_3_22_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.fitote.2012.01.004"},{"key":"e_1_3_3_23_2","first-page":"485","article-title":"Antinociceptive effect of Valeriana fauriei regulates BDNF signaling in an animal model of fibromyalgia","volume":"41","author":"Lee H","year":"2018","unstructured":"Lee H, , Im J, , Won H, et al. Antinociceptive effect of Valeriana fauriei regulates BDNF signaling in an animal model of fibromyalgia. Int J Mol Med, 2018; 41:485\u2013492.","journal-title":"Int J Mol Med"},{"key":"e_1_3_3_24_2","doi-asserted-by":"publisher","DOI":"10.3892\/ijmm.2016.2589"},{"key":"e_1_3_3_25_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature11556"},{"key":"e_1_3_3_26_2","doi-asserted-by":"publisher","DOI":"10.1002\/jnr.20754"},{"key":"e_1_3_3_27_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jgr.2017.04.012"},{"key":"e_1_3_3_28_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.physbeh.2006.08.021"},{"key":"e_1_3_3_29_2","doi-asserted-by":"publisher","DOI":"10.1177\/0269881111415735"},{"key":"e_1_3_3_30_2","doi-asserted-by":"publisher","DOI":"10.1038\/mp.2013.155"},{"key":"e_1_3_3_31_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuropharm.2016.01.033"},{"key":"e_1_3_3_32_2","doi-asserted-by":"publisher","DOI":"10.1007\/s12035-015-9230-2"},{"key":"e_1_3_3_33_2","doi-asserted-by":"publisher","DOI":"10.1007\/s12035-015-9131-4"},{"key":"e_1_3_3_34_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0138592"},{"key":"e_1_3_3_35_2","first-page":"327","article-title":"Behavioral despair in mice: A primary screening test for antidepressants","volume":"229","author":"Porsolt RD","year":"1977","unstructured":"Porsolt RD, , Bertin A, , Jalfre M. Behavioral despair in mice: A primary screening test for antidepressants. Arch Int Pharmacodyn Ther, 1977; 229:327\u2013336.","journal-title":"Arch Int Pharmacodyn Ther"},{"key":"e_1_3_3_36_2","doi-asserted-by":"publisher","DOI":"10.1196\/annals.1296.017"},{"key":"e_1_3_3_37_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.brainres.2006.06.077"},{"key":"e_1_3_3_38_2","doi-asserted-by":"publisher","DOI":"10.3389\/fncel.2015.00521"},{"key":"e_1_3_3_39_2","doi-asserted-by":"publisher","DOI":"10.1155\/2015\/898393"},{"key":"e_1_3_3_40_2","doi-asserted-by":"publisher","DOI":"10.1037\/a0035302"},{"key":"e_1_3_3_41_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.tins.2015.08.001"},{"key":"e_1_3_3_42_2","doi-asserted-by":"publisher","DOI":"10.1001\/jamapsychiatry.2014.1611"},{"key":"e_1_3_3_43_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.pnpbp.2014.10.003"},{"key":"e_1_3_3_44_2","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-pharmtox-011112-140320"},{"key":"e_1_3_3_45_2","doi-asserted-by":"publisher","DOI":"10.1038\/npp.2014.176"},{"key":"e_1_3_3_46_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.pnpbp.2012.09.008"},{"key":"e_1_3_3_47_2","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-642-45106-5_17"},{"key":"e_1_3_3_48_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.neulet.2015.04.036"},{"key":"e_1_3_3_49_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.brainres.2014.06.031"}],"container-title":["Rejuvenation Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1089\/rej.2018.2157","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1089\/rej.2018.2157","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1089\/rej.2018.2157","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,2]],"date-time":"2026-05-02T01:34:45Z","timestamp":1777685685000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/full\/10.1089\/rej.2018.2157"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,6]]},"references-count":48,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2020,6]]}},"alternative-id":["10.1089\/rej.2018.2157"],"URL":"https:\/\/doi.org\/10.1089\/rej.2018.2157","relation":{},"ISSN":["1549-1684","1557-8577"],"issn-type":[{"value":"1549-1684","type":"print"},{"value":"1557-8577","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,6]]}}}