{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,29]],"date-time":"2026-07-29T12:13:39Z","timestamp":1785327219043,"version":"3.55.0"},"reference-count":41,"publisher":"SAGE Publications","issue":"6","license":[{"start":{"date-parts":[[2020,12,1]],"date-time":"2020-12-01T00:00:00Z","timestamp":1606780800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Rejuvenation Research"],"published-print":{"date-parts":[[2020,12]]},"abstract":"<jats:p>\n                    The benefits of aerobic exercise in persons with Parkinson's disease (PD) have been widely studied. Recent studies support the use of high-intensity aerobic exercise to improve oxidative stress values and functional performance in PD patients. The aim of this study is ascertain whether high-intensity aerobic training with lower extremity cycle ergometers and balance training can improve motor symptoms and quality of life in a PD population of Hoehn and Yahr disability score 1\u20133. The intervention took place in rehabilitation centers in secondary care. A pilot randomized controlled trial was carried out with 14 outpatients participated in the 8-week study. They were composed of a control group (CG;\n                    <jats:italic toggle=\"yes\">n<\/jats:italic>\n                    \u2009=\u20097) that followed a balance protocol and an experimental group (EG;\n                    <jats:italic toggle=\"yes\">n<\/jats:italic>\n                    \u2009=\u20097) that performed high-intensity (70% heart rate reserve) aerobic workout using a lower extremity cycle ergometer and a balance protocol once a week. The primary outcome measures included the 8-Foot Up-and-Go test, 6-Minute Walk test, 2-Minute Step test, Parkinson's Disease Questionnaire (PDQ39), Movement Disorder Society\u2014Unified Parkinson's Disease Rating Scale (MDS-UPDRS) and Tinetti test. Significant improvements in the PDQ39 (\n                    <jats:italic toggle=\"yes\">F<\/jats:italic>\n                    <jats:sub>1.23<\/jats:sub>\n                    \u2009=\u20093.102; sig\u2009=\u20090.036), the MDS-UPDRS III (\n                    <jats:italic toggle=\"yes\">F<\/jats:italic>\n                    <jats:sub>1.23<\/jats:sub>\n                    \u2009=\u20094.723; sig\u2009=\u20090.033), and MDS-UPDRS Total (\n                    <jats:italic toggle=\"yes\">F<\/jats:italic>\n                    <jats:sub>1.23<\/jats:sub>\n                    \u2009=\u20094.117; sig\u2009=\u20090.047) were observed in the EG as against the CG. After taking into account the number of subjects in each group, the results suggest that the PD population can withstand high-intensity aerobic workouts with a lower extremity cycle ergometer. This exercise is a beneficial therapy for them because it reduces motor symptoms of the disease and furthermore increases and improves patient's quality of life.\n                  <\/jats:p>","DOI":"10.1089\/rej.2019.2267","type":"journal-article","created":{"date-parts":[[2020,4,25]],"date-time":"2020-04-25T04:21:54Z","timestamp":1587788514000},"page":"508-515","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":22,"title":["Effects of a High-Intensity Progressive-Cycle Program on Quality of Life and Motor Symptomatology in a Parkinson's Disease Population: A Pilot Randomized Controlled Trial"],"prefix":"10.1177","volume":"23","author":[{"given":"Jos\u00e9 M.","family":"Cancela","sequence":"first","affiliation":[{"name":"Faculty of Education and Sport Science, University of Vigo, Pontevedra, Spain."},{"name":"Galicia Sur Health Research Institute (IIS Galicia Sur), HealthyFit Research Group, Sergas-UVIGO, Pontevedra, Spain."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Irimia","family":"Mollinedo","sequence":"additional","affiliation":[{"name":"Faculty of Education and Sport Science, University of Vigo, Pontevedra, Spain."},{"name":"Galicia Sur Health Research Institute (IIS Galicia Sur), HealthyFit Research Group, Sergas-UVIGO, Pontevedra, Spain."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sandro","family":"Montalvo","sequence":"additional","affiliation":[{"name":"Faculty of Education and Sport Science, University of Vigo, Pontevedra, Spain."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mar\u00eda Elena","family":"Vila Su\u00e1rez","sequence":"additional","affiliation":[{"name":"Faculty of Education and Sport Science, University of Vigo, Pontevedra, Spain."},{"name":"Galicia Sur Health Research Institute (IIS Galicia Sur), HealthyFit Research Group, Sergas-UVIGO, Pontevedra, Spain."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2020,12,15]]},"reference":[{"key":"e_1_3_4_2_2","doi-asserted-by":"publisher","DOI":"10.33588\/rn.3801.2003294"},{"key":"e_1_3_4_3_2","doi-asserted-by":"publisher","DOI":"10.1002\/mds.21690"},{"key":"e_1_3_4_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.humov.2015.12.009"},{"key":"e_1_3_4_5_2","doi-asserted-by":"publisher","DOI":"10.1007\/s11910-014-0451-y"},{"key":"e_1_3_4_6_2","first-page":"59","article-title":"Case study on an aquatic therapy program for Parkinson's patients","volume":"45","author":"Mar\u00edn EB","year":"2016","unstructured":"Mar\u00edn EB, , Gil JL. 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