{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,31]],"date-time":"2026-10-31T22:09:03Z","timestamp":1793484543958,"version":"4.5.0"},"reference-count":31,"publisher":"SAGE Publications","issue":"5","license":[{"start":{"date-parts":[[2020,10,1]],"date-time":"2020-10-01T00:00:00Z","timestamp":1601510400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Rejuvenation Research"],"published-print":{"date-parts":[[2020,10]]},"abstract":"<jats:p>\n                    Limited data are available on the prevalence and correlates of statin use for secondary cardiovascular (CV) prevention in the older adult population. We used data of older adults (65\u201379 years) with established atherosclerotic CV disease from the cross-sectional Italian Health Examination Survey 2008\u20132012 to address this issue. Lifestyles, CV risk factors, chronic diseases, and therapies were assessed using standardized procedures. A comprehensive geriatric assessment was performed to evaluate cognitive function, disability in basic activities of daily living\/instrumental activities of daily living, mobility, and polypharmacy. Multiple regression analyses were performed to identify independent correlates of statin use. A total of 392 participants (mean age 72.1\u2009\u00b1\u20094.4 years, 61.5% men) were considered for this analysis. Coronary heart disease was identified in 67.1% of participants, cerebrovascular disease in 23.5%, and peripheral artery disease (PAD) in 18.1%. One hundred ninety (48.5%) were statin users. By multiple regression analysis, functional disability (odds ratio [OR]\u2009=\u20090.81; 95% confidence interval [CI]\u2009=\u20090.71\u20130.92;\n                    <jats:italic toggle=\"yes\">p<\/jats:italic>\n                    \u2009=\u20090.002), cognitive impairment (OR\u2009=\u20090.87; 95% CI\u2009=\u20090.78\u20130.98;\n                    <jats:italic toggle=\"yes\">p<\/jats:italic>\n                    \u2009=\u20090.018), and polypharmacy (OR\u2009=\u20090.86; 95% CI\u2009=\u20090.75\u20130.98;\n                    <jats:italic toggle=\"yes\">p<\/jats:italic>\n                    \u2009=\u20090.035) predicted statin nonuse, whereas having hypertension (OR\u2009=\u20091.19; 95% CI\u2009=\u20091.05\u20131.34;\n                    <jats:italic toggle=\"yes\">p<\/jats:italic>\n                    \u2009=\u20090.005), diabetes mellitus (OR\u2009=\u20091.14; 95% CI\u2009=\u20091.03\u20131.27;\n                    <jats:italic toggle=\"yes\">p<\/jats:italic>\n                    \u2009=\u20090.013), or a previous myocardial revascularization (OR\u2009=\u20091.31; 95% CI\u2009=\u20091.16\u20131.48;\n                    <jats:italic toggle=\"yes\">p<\/jats:italic>\n                    \u2009&lt;\u20090.001) predicted statin use. Significant interaction terms were observed between cerebrovascular disease, PAD, cognitive impairment, and disability in predicting statin nonuse. Statin underuse in older adults aged 65\u201379 years with CV disease, and thus suboptimal secondary CV prevention, is highly prevalent despite current guidelines and recommendations. Common geriatric conditions are associated with statin nonuse. Such results support the need for improving the awareness of statin treatment for secondary CV prevention.\n                  <\/jats:p>","DOI":"10.1089\/rej.2019.2268","type":"journal-article","created":{"date-parts":[[2020,2,1]],"date-time":"2020-02-01T04:33:02Z","timestamp":1580531582000},"page":"394-400","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":9,"title":["Prevalence and Correlates of Statin Underuse for Secondary Prevention of Cardiovascular Disease in Older Adults 65\u201379 Years of Age: The Italian Health Examination Survey 2008\u20132012"],"prefix":"10.1177","volume":"23","author":[{"given":"Giovanni","family":"Viscogliosi","sequence":"first","affiliation":[{"name":"Department of Cardiovascular, Dysmetabolic and Ageing-Associated Diseases, National Institute of Health, Rome, Italy."},{"name":"Department of Epidemiology, Centre of Epidemiology and Biostatistics, Polytechnic University of Marche, Ancona, Italy."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chiara","family":"Donfrancesco","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular, Dysmetabolic and Ageing-Associated Diseases, National Institute of Health, Rome, Italy."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cinzia","family":"Lo Noce","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular, Dysmetabolic and Ageing-Associated Diseases, National Institute of Health, Rome, Italy."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Diego","family":"Vanuzzo","sequence":"additional","affiliation":[{"name":"Department of Cardiology, National Association Hospital Cardiologists, Florence, Italy."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Flavia","family":"Carle","sequence":"additional","affiliation":[{"name":"Department of Epidemiology, Centre of Epidemiology and Biostatistics, Polytechnic University of Marche, Ancona, Italy."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Simona","family":"Giampaoli","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular, Dysmetabolic and Ageing-Associated Diseases, National Institute of Health, Rome, Italy."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luigi","family":"Palmieri","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular, Dysmetabolic and Ageing-Associated Diseases, National Institute of Health, Rome, Italy."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2020,10,15]]},"reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.cir.0000437738.63853.7a"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1001\/archinte.164.13.1427"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2011.02.014"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.1161\/JAHA.118.008546"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.1111\/jgs.15144"},{"key":"e_1_3_3_7_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12875-016-0505-0"},{"key":"e_1_3_3_8_2","doi-asserted-by":"publisher","DOI":"10.1517\/14740338.4.3.389"},{"key":"e_1_3_3_9_2","doi-asserted-by":"publisher","DOI":"10.1093\/gerona\/glw082"},{"key":"e_1_3_3_10_2","doi-asserted-by":"publisher","DOI":"10.1111\/jgs.13953"},{"key":"e_1_3_3_11_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0166857"},{"key":"e_1_3_3_12_2","doi-asserted-by":"publisher","DOI":"10.1161\/JAHA.117.005658"},{"key":"e_1_3_3_13_2","doi-asserted-by":"publisher","DOI":"10.1159\/000488450"},{"key":"e_1_3_3_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2017.02.064"},{"key":"e_1_3_3_15_2","doi-asserted-by":"publisher","DOI":"10.1136\/bmjopen-2017-018184"},{"key":"e_1_3_3_16_2","doi-asserted-by":"publisher","DOI":"10.1161\/HCQ.0000000000000008"},{"key":"e_1_3_3_17_2","first-page":"1S","article-title":"Cardiovascular health in Italians. 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