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With increasing age the circadian clock in humans and other mammals becomes increasingly disorganized leading to a large number of more or less well-categorized problems. While a lot of aging research has focused on the peripheral clocks in tissues across organisms, it remains a paramount task to quantify aging of the most important master clock, the human SCN. Furthermore, a pipeline needs to be developed with therapies to mitigate the systemic cellular circadian dysfunction in the elderly and ultimately repair and reverse aging of the SCN itself. A disease classification for the aging SCN,\n                    <jats:italic toggle=\"yes\">Circadian Clock Neuronal Senile Atrophy<\/jats:italic>\n                    (CIRCLONSA syndrome), would improve research funding and goal-oriented biotechnological entrepreneurship.\n                  <\/jats:p>","DOI":"10.1089\/rej.2020.2388","type":"journal-article","created":{"date-parts":[[2021,2,12]],"date-time":"2021-02-12T01:50:45Z","timestamp":1613094645000},"page":"274-282","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":3,"title":["Aging of the Suprachiasmatic Nucleus,\n                    <i>CIRCLONSA Syndrome<\/i>\n                    , Implications for Regenerative Medicine and Restoration of the Master Body Clock"],"prefix":"10.1177","volume":"24","author":[{"given":"Victor","family":"Bj\u00f6rk","sequence":"first","affiliation":[{"name":"Ichor Therapeutics, Lafayette, New York, USA."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2021,8,16]]},"reference":[{"key":"e_1_3_4_2_2","doi-asserted-by":"publisher","DOI":"10.3389\/fpubh.2017.00335"},{"key":"e_1_3_4_3_2","doi-asserted-by":"publisher","DOI":"10.3389\/fgene.2015.00205"},{"key":"e_1_3_4_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2013.05.039"},{"key":"e_1_3_4_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2020.11.034"},{"key":"e_1_3_4_6_2","doi-asserted-by":"publisher","DOI":"10.1111\/ejn.14358"},{"key":"e_1_3_4_7_2","doi-asserted-by":"publisher","DOI":"10.1177\/074873098129000255"},{"key":"e_1_3_4_8_2","doi-asserted-by":"publisher","DOI":"10.3389\/fnmol.2019.00132"},{"key":"e_1_3_4_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ncl.2012.08.011"},{"key":"e_1_3_4_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ncl.2019.04.003"},{"key":"e_1_3_4_11_2","unstructured":"NIH news release. 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