{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T02:56:21Z","timestamp":1791860181796,"version":"4.3.4"},"reference-count":33,"publisher":"SAGE Publications","issue":"4","license":[{"start":{"date-parts":[[2021,8,1]],"date-time":"2021-08-01T00:00:00Z","timestamp":1627776000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Rejuvenation Research"],"published-print":{"date-parts":[[2021,8]]},"abstract":"<jats:p>\n                    The diabetic foot ulcer (DFU) is a major disabling complication of diabetes mellitus. Growing evidence suggests that topical erythropoietin (EPO) can promote wound healing. The aim of this study is to clinically assess the efficacy of a proprietary topical EPO-containing hydrogel for treating DFUs. We conducted a randomized, controlled trial in 20 patients with DFUs. After a 14-day screening period, the DFUs of 20 eligible participants who fulfilled the inclusion criteria were randomly assigned (1:1) to either a 12-week of daily treatment with topical EPO and standard-of-care (SOC) or SOC treatment alone. The DFUs were assessed weekly until week 12. The primary outcome was 75% ulcer closure or higher. After 12 weeks of treatment, 75% ulcer closure was achieved in 6 of the 10 patients whose DFUs were treated with topical EPO and in one of the 8 patients whose DFUs were treated with SOC alone. The mean area of the DFUs that were treated with topical EPO and SOC was significantly smaller than those treated with SOC alone (1.2\u2009\u00b1\u20091.4\u2009cm\n                    <jats:sup>2<\/jats:sup>\n                    vs. 4.2\u2009\u00b1\u20093.4\u2009cm\n                    <jats:sup>2<\/jats:sup>\n                    ;\n                    <jats:italic toggle=\"yes\">p<\/jats:italic>\n                    \u2009=\u20090.023). Re-epithelialization was faster in the topically EPO-treated DFUs than in the SOC-treated DFUs. There were no treatment-related adverse events. We conclude that topical EPO is a promising treatment for promoting the healing of DFUs.\n                  <\/jats:p>\n                  <jats:p>Clinical Trial Registration number: NCT02361931.<\/jats:p>","DOI":"10.1089\/rej.2020.2397","type":"journal-article","created":{"date-parts":[[2021,1,28]],"date-time":"2021-01-28T01:04:07Z","timestamp":1611795847000},"page":"251-261","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":20,"title":["Topical Erythropoietin Accelerates Wound Closure in Patients with Diabetic Foot Ulcers: A Prospective, Multicenter, Single-Blind, Randomized, Controlled Trial"],"prefix":"10.1177","volume":"24","author":[{"given":"Saher","family":"Hamed","sequence":"first","affiliation":[{"name":"Department of Research and Development, Remedor Biomed Ltd., Nazareth Illit, Israel."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yehuda","family":"Ullmann","sequence":"additional","affiliation":[{"name":"Department of Plastic and Reconstructive Surgery, Rambam Health Care Campus, Haifa, Israel."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark","family":"Belokopytov","sequence":"additional","affiliation":[{"name":"Department of Research and Development, Remedor Biomed Ltd., Nazareth Illit, Israel."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aziz","family":"Shoufani","sequence":"additional","affiliation":[{"name":"Department of Plastic Surgery and General Surgery, Emek Medical Center, Afula, Israel."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hoda","family":"Kabha","sequence":"additional","affiliation":[{"name":"Department of Research and Development, Remedor Biomed Ltd., Nazareth Illit, Israel."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Suher","family":"Masri","sequence":"additional","affiliation":[{"name":"Department of Research and Development, Remedor Biomed Ltd., Nazareth Illit, Israel."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zeev","family":"Feldbrin","sequence":"additional","affiliation":[{"name":"Diabetes Foot Care Unit, Wolfson Medical Center, Holon, Israel."},{"name":"Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leonid","family":"Kogan","sequence":"additional","affiliation":[{"name":"Department of Plastic Surgery, Western Galilee Medical Center, Nahariya, Israel."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Danny","family":"Kruchevsky","sequence":"additional","affiliation":[{"name":"Department of Plastic and Reconstructive Surgery, Rambam Health Care Campus, Haifa, Israel."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roger","family":"Najjar","sequence":"additional","affiliation":[{"name":"Department of Plastic Surgery, Western Galilee Medical Center, Nahariya, Israel."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul Y.","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Plastic Surgery, Rhode Island Hospital and Alpert Medical School of Brown University, Providence, Rhode Island, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean-Charles","family":"Kerihuel","sequence":"additional","affiliation":[{"name":"Vertical, Paris, France."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sadanori","family":"Akita","sequence":"additional","affiliation":[{"name":"Department Wound Care and Plastic and Reconstructive Surgery, Fukuoka University, Fukuoka, Japan."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luc","family":"Teot","sequence":"additional","affiliation":[{"name":"Department of Plastic and Reconstructive Surgery and Wound Healing, Montpellier University Hospital, Lapeyronie, Montpellier, France."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2021,8,16]]},"reference":[{"key":"e_1_3_6_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(05)67698-2"},{"key":"e_1_3_6_3_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra1615439"},{"key":"e_1_3_6_4_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0134914"},{"key":"e_1_3_6_5_2","doi-asserted-by":"publisher","DOI":"10.2337\/dc13-2176"},{"key":"e_1_3_6_6_2","doi-asserted-by":"publisher","DOI":"10.1080\/14737167.2017.1305891"},{"key":"e_1_3_6_7_2","doi-asserted-by":"publisher","DOI":"10.1002\/dmrr.2694"},{"key":"e_1_3_6_8_2","first-page":"16","article-title":"Management of diabetic foot ulcers: A review","volume":"33","author":"Frykberg RG","year":"2016","unstructured":"Frykberg RG, , Banks J. Management of diabetic foot ulcers: A review. Fed Pract, 2016; 33:16\u201323.","journal-title":"Fed Pract"},{"key":"e_1_3_6_9_2","doi-asserted-by":"publisher","DOI":"10.1111\/wrr.12391"},{"key":"e_1_3_6_10_2","doi-asserted-by":"publisher","DOI":"10.1007\/s11892-018-0970-z"},{"key":"e_1_3_6_11_2","doi-asserted-by":"publisher","DOI":"10.2337\/db12-0227"},{"key":"e_1_3_6_12_2","doi-asserted-by":"publisher","DOI":"10.12968\/jowc.2016.25.5.277"},{"key":"e_1_3_6_13_2","doi-asserted-by":"publisher","DOI":"10.1038\/jid.2009.219"},{"key":"e_1_3_6_14_2","doi-asserted-by":"publisher","DOI":"10.1038\/jid.2011.15"},{"key":"e_1_3_6_15_2","doi-asserted-by":"publisher","DOI":"10.1111\/wrr.12135"},{"key":"e_1_3_6_16_2","doi-asserted-by":"publisher","DOI":"10.2337\/db16-1205"},{"key":"e_1_3_6_17_2","doi-asserted-by":"publisher","DOI":"10.1089\/wound.2018.0808"},{"key":"e_1_3_6_18_2","doi-asserted-by":"publisher","DOI":"10.2337\/diacare.24.1.84"},{"key":"e_1_3_6_19_2","doi-asserted-by":"publisher","DOI":"10.1053\/j.jfas.2015.12.009"},{"key":"e_1_3_6_20_2","doi-asserted-by":"publisher","DOI":"10.1089\/rej.2010.1050"},{"key":"e_1_3_6_21_2","first-page":"4","article-title":"First results on three patients treated with topical recombinant human erythropoietin (rhEPO) to improve wound healing in diabetic foot ulcers","volume":"2","author":"Gunter CI","year":"2015","unstructured":"Gunter CI, , Kern1\u2009L, Giri S, , Machens HG, , Bader A. First results on three patients treated with topical recombinant human erythropoietin (rhEPO) to improve wound healing in diabetic foot ulcers. 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