{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,19]],"date-time":"2026-06-19T05:32:38Z","timestamp":1781847158661,"version":"3.54.5"},"reference-count":67,"publisher":"SAGE Publications","issue":"6","license":[{"start":{"date-parts":[[2022,12,1]],"date-time":"2022-12-01T00:00:00Z","timestamp":1669852800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Rejuvenation Research"],"published-print":{"date-parts":[[2022,12]]},"abstract":"<jats:p>\n                    Huntington's disease (HD) is an inherited neurodegenerative disease. 3-Nitropropionic acid (3-NP) causes increased reactive oxygen species production and neuroinflammation.\n                    <jats:italic toggle=\"yes\">Centella asiatica<\/jats:italic>\n                    (CA) is a strong antioxidant. The aim of this study is to investigate the effect of hydroalcoholic extract of\n                    <jats:italic toggle=\"yes\">C. asiatica<\/jats:italic>\n                    (HA-CA) on 3-NP-induced HD in adult zebrafish. Adult zebrafish (\u223c5\u20136 months old) weighing 470 to 530\u2009mg was used and treated with 3-NP (5\u2009mg\/kg intraperitoneal [\n                    <jats:italic toggle=\"yes\">i.p.<\/jats:italic>\n                    ]). The animals received HA-CA (80 and 100\u2009mg\/L) daily for up to 28 days in water. Tetrabenazine (3\u2009mg\/kg\n                    <jats:italic toggle=\"yes\">i.p.<\/jats:italic>\n                    ) was used as a standard drug. We have done an open field test (for locomotor activity), a novel tank diving test (for anxiety), and a light and dark tank test (for memory), followed by biochemical analysis (acetyl-cholinesterase [AchEs], nitrite, lipid peroxidation [LPO], and glutathione [GSH]) and histopathology to further confirm memory dysfunctions. 3-NP-treated zebrafish exhibit reductions in body weight, progressive neuronal damage, cognition, and locomotor activity. The HA-CA group significantly reduced the 3-NP-induced increase in LPO, AchEs, and nitrite levels while decreasing GSH levels. Oral administration of HA-CA (80 or 100\u2009mg\/L) significantly reduces 3-NP-induced changes in body weight and behaviors, in addition to neuroinflammation in the brain by lowering tumor necrosis factor-\u03b1 and interleukin-1\u03b2 levels. Moreover, HA-CA significantly decreases the 3-NP-induced neuronal damage in the brain. HA-CA ameliorates neurotoxicity and neurobehavioral deficits in 3-NP-induced HD-like symptoms in adult zebrafish.\n                  <\/jats:p>","DOI":"10.1089\/rej.2022.0036","type":"journal-article","created":{"date-parts":[[2022,9,23]],"date-time":"2022-09-23T14:53:44Z","timestamp":1663944824000},"page":"260-274","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":17,"title":["Neuroprotective Potential of Hydroalcoholic Extract of\n                    <i>Centella asiatica<\/i>\n                    Against 3-Nitropropionic Acid-Induced Huntington's Like Symptoms in Adult Zebrafish"],"prefix":"10.1177","volume":"25","author":[{"given":"Vishal","family":"Kumar","sequence":"first","affiliation":[{"name":"Department of Pharmacology, ISF College of Pharmacy, Moga, Affiliated to IK Gujral Punjab Technical University, Jalandhar, India."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Charan","family":"Singh","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutics, ISF College of Pharmacy, Moga, Affiliated to IK Gujral Punjab Technical University, Jalandhar, India."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arti","family":"Singh","sequence":"additional","affiliation":[{"name":"Department of Pharmacology, ISF College of Pharmacy, Moga, Affiliated to IK Gujral Punjab Technical University, Jalandhar, India."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2022,12,12]]},"reference":[{"key":"e_1_3_6_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.toxrep.2015.08.004"},{"key":"e_1_3_6_3_2","doi-asserted-by":"publisher","DOI":"10.2217\/nmt-2016-0008"},{"key":"e_1_3_6_4_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41582-020-0389-4"},{"key":"e_1_3_6_5_2","doi-asserted-by":"publisher","DOI":"10.2174\/1570159X19666210609160017"},{"key":"e_1_3_6_6_2","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp.2007.142380"},{"key":"e_1_3_6_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbr.2014.01.048"},{"key":"e_1_3_6_8_2","doi-asserted-by":"publisher","DOI":"10.1007\/s11033-021-06787-y"},{"key":"e_1_3_6_9_2","first-page":"647","article-title":"HDAC11: A novel inflammatory biomarker in Huntington's disease","volume":"21","author":"Kumar V","year":"2022","unstructured":"Kumar V, , Kaur S, , Kapil L, et al. 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