{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,16]],"date-time":"2026-07-16T17:41:52Z","timestamp":1784223712648,"version":"3.55.0"},"reference-count":33,"publisher":"SAGE Publications","issue":"2","license":[{"start":{"date-parts":[[2023,4,1]],"date-time":"2023-04-01T00:00:00Z","timestamp":1680307200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Rejuvenation Research"],"published-print":{"date-parts":[[2023,4]]},"abstract":"<jats:p>\n                    Data regarding plant extracts with antiaging properties, particularly through the biological process involving telomeres and telomerase, are limited. Thus, this study aimed to investigate the effects of\n                    <jats:italic toggle=\"yes\">Acanthopanax senticosus<\/jats:italic>\n                    extract (ASE) supplementation on leukocyte telomere length (LTL), telomerase, and inflammatory and metabolic markers in adult animal models. A freeze-dried product of ethanol extracts was prepared using a mixture product of stem and root ASE. In a 24-week experiment that included 24-week-old Sprague Dawley male rats, experimental rats (\n                    <jats:italic toggle=\"yes\">n<\/jats:italic>\n                    \u2009=\u200910) were administrated with 7\u2009mg\/day of ASE dissolved in saline and control rats (\n                    <jats:italic toggle=\"yes\">n<\/jats:italic>\n                    \u2009=\u200910) with saline. All rats had access to chow and tap water\n                    <jats:italic toggle=\"yes\">ad libitum<\/jats:italic>\n                    . Their LTL and plasma levels of telomerase and inflammatory and metabolic markers were assayed and compared between the two groups. The experimental rats showed significantly longer LTL (\n                    <jats:italic toggle=\"yes\">p<\/jats:italic>\n                    \u2009&lt;\u20090.05) and lower plasma levels of alanine aminotransferase (\n                    <jats:italic toggle=\"yes\">p<\/jats:italic>\n                    \u2009&lt;\u20090.05) and aspartate aminotransferase (\n                    <jats:italic toggle=\"yes\">p<\/jats:italic>\n                    \u2009=\u20090.08) compared with the control. In addition, LTL was correlated with the aforementioned biochemical parameters of liver function test among experimental rats only. No significant differences in plasma levels of telomerase and inflammatory and metabolic markers were observed. These findings indicate that ASE supplementation may attenuate LTL shortening and reduce liver biochemical parameters, indicating its potential antiaging and hepatoprotective effects without any adverse metabolic response.\n                  <\/jats:p>","DOI":"10.1089\/rej.2022.0051","type":"journal-article","created":{"date-parts":[[2022,12,28]],"date-time":"2022-12-28T05:24:34Z","timestamp":1672205074000},"page":"51-56","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":9,"title":["Potential Antiaging and Hepatoprotective Effects of\n                    <i>Acanthopanax senticosus<\/i>\n                    Extracts in Adult Rat Models"],"prefix":"10.1177","volume":"26","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4441-4005","authenticated-orcid":false,"given":"Chaeyeong","family":"Kim","sequence":"first","affiliation":[{"name":"Department of Foods and Nutrition, College of Science and Technology, Kookmin University, Seoul, Republic of Korea."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9112-273X","authenticated-orcid":false,"given":"Hye Min","family":"Bae","sequence":"additional","affiliation":[{"name":"Department of Foods and Nutrition, College of Science and Technology, Kookmin University, Seoul, Republic of Korea."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9524-4344","authenticated-orcid":false,"given":"Inkyung","family":"Baik","sequence":"additional","affiliation":[{"name":"Department of Foods and Nutrition, College of Science and Technology, Kookmin University, Seoul, Republic of Korea."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2023,4,4]]},"reference":[{"key":"e_1_3_4_2_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature01385"},{"key":"e_1_3_4_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2013.05.039"},{"key":"e_1_3_4_4_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra0903373"},{"key":"e_1_3_4_5_2","doi-asserted-by":"publisher","DOI":"10.1111\/1440-1681.12758"},{"key":"e_1_3_4_6_2","doi-asserted-by":"publisher","DOI":"10.1038\/350569a0"},{"key":"e_1_3_4_7_2","doi-asserted-by":"publisher","DOI":"10.1093\/advances\/nmz026"},{"key":"e_1_3_4_8_2","doi-asserted-by":"publisher","DOI":"10.3892\/mmr.2019.10614"},{"key":"e_1_3_4_9_2","doi-asserted-by":"publisher","DOI":"10.3390\/molecules200713281"},{"key":"e_1_3_4_10_2","doi-asserted-by":"publisher","DOI":"10.5536\/KJPS.2008.35.3.283"},{"key":"e_1_3_4_11_2","doi-asserted-by":"publisher","DOI":"10.3746\/jkfn.2009.38.8.977"},{"key":"e_1_3_4_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9258(18)88697-5"},{"key":"e_1_3_4_13_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1474-9726.2011.00700.x"},{"key":"e_1_3_4_14_2","doi-asserted-by":"publisher","DOI":"10.4103\/0976-0105.177703"},{"issue":"2","key":"e_1_3_4_15_2","first-page":"83","article-title":"Acanthopanax senticosus: Review of botany, chemistry and pharmacology","volume":"66","author":"Huang L","year":"2011","unstructured":"Huang L, , Zhao H, , Huang B, et al. Acanthopanax senticosus: Review of botany, chemistry and pharmacology. Pharmazie, 2011; 66(2):83\u201397.","journal-title":"Pharmazie"},{"key":"e_1_3_4_16_2","doi-asserted-by":"publisher","DOI":"10.1002\/jsfa.7557"},{"key":"e_1_3_4_17_2","doi-asserted-by":"publisher","DOI":"10.1002\/1099-1573(200011)14:7"},{"key":"e_1_3_4_18_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF02975184"},{"issue":"6","key":"e_1_3_4_19_2","first-page":"694","article-title":"Antioxidant and cell proliferation effects of Acanthopanax senticosus for extract in human osteoblast-like MG-63 cell line","volume":"39","author":"Lim SY","year":"2007","unstructured":"Lim SY, , Leem JY, , Lee CS, et al. Antioxidant and cell proliferation effects of Acanthopanax senticosus for extract in human osteoblast-like MG-63 cell line. Korean J Food Sci Technol, 2007; 39(6):694\u2013700.","journal-title":"Korean J Food Sci Technol"},{"key":"e_1_3_4_20_2","doi-asserted-by":"publisher","DOI":"10.1016\/s0378-8741(00)00181-1"},{"key":"e_1_3_4_21_2","doi-asserted-by":"publisher","DOI":"10.4163\/jnh.2019.52.5.413"},{"issue":"4","key":"e_1_3_4_22_2","first-page":"269","article-title":"Clinical effect of a polysaccharide-rich extract of Acanthopanax senticosus on alcohol hangover","volume":"70","author":"Bang JS","year":"2015","unstructured":"Bang JS, , Chung YH, , Chung SJ, et al. Clinical effect of a polysaccharide-rich extract of Acanthopanax senticosus on alcohol hangover. 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