{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,11]],"date-time":"2026-05-11T14:33:07Z","timestamp":1778509987989,"version":"3.51.4"},"reference-count":63,"publisher":"SAGE Publications","issue":"2","license":[{"start":{"date-parts":[[2024,4,1]],"date-time":"2024-04-01T00:00:00Z","timestamp":1711929600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Rejuvenation Research"],"published-print":{"date-parts":[[2024,4]]},"abstract":"<jats:p>\n                    Cardiac aging is defined as mitochondrial dysfunction of the heart. Vitamin D (VitD) is an effective agent in ameliorating cardiovascular disorders. In this study, we indicated the protective effects of VitD against cardiac aging. Male Wistar rats were randomly divided into four groups: control (CONT), D-galactose (D-GAL): aged rats induced by D-GAL, D-GAL + Ethanol: aged rats treated with ethanol, and D-GAL + VitD aged rats treated with VitD. Aging was induced by D-GAL at 150\u2009mg\/kg via intraperitoneal injection for 8 weeks. Aged rats were treated with VitD (D-GAL + VitD) by gavage for 8 weeks. The serum samples were used to evaluate biochemical factors, and heart tissues were assessed to determine oxidative stress and gene expression. The D-GAL rats exhibited cardiac hypertrophy, which was associated with decreased antioxidant enzyme activity, enhanced oxidative marker, and changes in the expression of mitochondrial genes in comparison with the control rats. Co-treatment with VitD ameliorated all these changes. In conclusion, VitD could protect the heart against D-GAL-induced aging via enhancin\n                    <jats:italic toggle=\"yes\">g<\/jats:italic>\n                    antioxidant effects, and the expression of mitochondrial genes.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:graphic xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" orientation=\"portrait\" position=\"float\" xlink:href=\"10.1089_rej.2023.0061-img51001.jpg\"\/>\n                  <\/jats:p>","DOI":"10.1089\/rej.2023.0061","type":"journal-article","created":{"date-parts":[[2024,2,3]],"date-time":"2024-02-03T03:06:16Z","timestamp":1706929576000},"page":"51-60","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":6,"title":["Vitamin D Protects Against Cardiac Hypertrophy Through the Regulation of Mitochondrial Function in Aging Rats"],"prefix":"10.1177","volume":"27","author":[{"given":"Siamak","family":"Shahidi","sequence":"first","affiliation":[{"name":"Department of Physiology, School of Medicine, Hamadan University of Medical Sciences, Hamadan, Iran."},{"name":"Department of Neuroscience, Neurophysiology Research Center, Hamadan University of Medical Sciences, Hamadan, Iran."},{"name":"Department of Neuroscience, School of Sciences and Advanced Technology in Medicine, Hamadan University of Medical Sciences, Hamadan, Iran."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alireza","family":"Komaki","sequence":"additional","affiliation":[{"name":"Department of Neuroscience, Neurophysiology Research Center, Hamadan University of Medical Sciences, Hamadan, Iran."},{"name":"Department of Neuroscience, School of Sciences and Advanced Technology in Medicine, Hamadan University of Medical Sciences, Hamadan, Iran."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Iraj","family":"Salehi","sequence":"additional","affiliation":[{"name":"Department of Neuroscience, Neurophysiology Research Center, Hamadan University of Medical Sciences, Hamadan, Iran."},{"name":"Department of Neuroscience, School of Sciences and Advanced Technology in Medicine, Hamadan University of Medical Sciences, Hamadan, Iran."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sara","family":"Soleimani Asl","sequence":"additional","affiliation":[{"name":"Department of Anatomy, School of Medicine, Hamadan University of Medical Sciences, Hamadan, Iran."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Parisa","family":"Habibi","sequence":"additional","affiliation":[{"name":"Department of Physiology, School of Medicine, Hamadan University of Medical Sciences, Hamadan, Iran."},{"name":"Department of Neuroscience, Neurophysiology Research Center, Hamadan University of Medical Sciences, Hamadan, Iran."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fatemeh","family":"Ramezani-Aliakbari","sequence":"additional","affiliation":[{"name":"Department of Physiology, School of Medicine, Hamadan University of Medical Sciences, Hamadan, Iran."},{"name":"Department of Neuroscience, Neurophysiology Research Center, Hamadan University of Medical Sciences, Hamadan, Iran."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2024,4,5]]},"reference":[{"key":"e_1_3_8_2_2","doi-asserted-by":"publisher","DOI":"10.1007\/s12551-017-0255-9"},{"key":"e_1_3_8_3_2","doi-asserted-by":"publisher","DOI":"10.1007\/s10522-019-09837-y"},{"key":"e_1_3_8_4_2","doi-asserted-by":"publisher","DOI":"10.1007\/s10522-020-09900-z"},{"key":"e_1_3_8_5_2","doi-asserted-by":"publisher","DOI":"10.1007\/s11033-023-08670-4"},{"key":"e_1_3_8_6_2","doi-asserted-by":"publisher","DOI":"10.1007\/s11033-023-08875-7"},{"key":"e_1_3_8_7_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00210-023-02692-2"},{"key":"e_1_3_8_8_2","doi-asserted-by":"publisher","DOI":"10.1101\/cshperspect.a025148"},{"key":"e_1_3_8_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbadis.2016.11.010"},{"key":"e_1_3_8_10_2","doi-asserted-by":"publisher","DOI":"10.3389\/fphys.2022.1040381"},{"key":"e_1_3_8_11_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.RES.0000117088.36577.EB"},{"key":"e_1_3_8_12_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCRESAHA.109.212753"},{"key":"e_1_3_8_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.mito.2015.10.001"},{"key":"e_1_3_8_14_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0119687"},{"key":"e_1_3_8_15_2","doi-asserted-by":"publisher","DOI":"10.1042\/BJ20091286"},{"key":"e_1_3_8_16_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.freeradbiomed.2010.08.010"},{"key":"e_1_3_8_17_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.arr.2015.12.005"},{"key":"e_1_3_8_18_2","doi-asserted-by":"publisher","DOI":"10.3390\/ijms23010183"},{"key":"e_1_3_8_19_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.atherosclerosis.2016.05.019"},{"key":"e_1_3_8_20_2","doi-asserted-by":"publisher","DOI":"10.5152\/akd.2014.5637"},{"key":"e_1_3_8_21_2","doi-asserted-by":"publisher","DOI":"10.1093\/ajcn\/83.4.754"},{"key":"e_1_3_8_22_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2016.03.508"},{"key":"e_1_3_8_23_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCRESAHA.113.301241"},{"key":"e_1_3_8_24_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.numecd.2018.04.010"},{"key":"e_1_3_8_25_2","doi-asserted-by":"publisher","DOI":"10.1113\/JP274887"},{"key":"e_1_3_8_26_2","doi-asserted-by":"publisher","DOI":"10.3390\/ijms21134777"},{"key":"e_1_3_8_27_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.yjmcc.2014.02.002"},{"key":"e_1_3_8_28_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.yjmcc.2014.03.001"},{"key":"e_1_3_8_29_2","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2020.604700"},{"key":"e_1_3_8_30_2","doi-asserted-by":"publisher","DOI":"10.1038\/ki.1986.258"},{"key":"e_1_3_8_31_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-019-50679-y"},{"key":"e_1_3_8_32_2","doi-asserted-by":"publisher","DOI":"10.1007\/s40520-018-1075-x"},{"key":"e_1_3_8_33_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2018.03.103"},{"key":"e_1_3_8_34_2","first-page":"12","article-title":"Inhibition of cardiac hypertrophy effects in D-galactose-induced senescent hearts by alpinate oxyphyllae fructus treatment","volume":"624384","author":"Chang Y-M","year":"2017","unstructured":"Chang Y-M, , Chang H-H, , Lin H-J, et al. Inhibition of cardiac hypertrophy effects in D-galactose-induced senescent hearts by alpinate oxyphyllae fructus treatment. Evid based Complement Altern Med, 2017; 624384L:12; doi: 10.1155\/2017\/2624384.","journal-title":"Evid based Complement Altern Med"},{"key":"e_1_3_8_35_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.288.20.2579"},{"key":"e_1_3_8_36_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00253-022-12041-7"},{"key":"e_1_3_8_37_2","doi-asserted-by":"publisher","DOI":"10.3390\/molecules24101911"},{"key":"e_1_3_8_38_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.1106653"},{"key":"e_1_3_8_39_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.93.18.9782"},{"key":"e_1_3_8_40_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.neulet.2021.135963"},{"key":"e_1_3_8_41_2","doi-asserted-by":"publisher","DOI":"10.5681\/bi.2013.003"},{"key":"e_1_3_8_42_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCRESAHA.116.307474"},{"key":"e_1_3_8_43_2","doi-asserted-by":"publisher","DOI":"10.1136\/hrt.2005.068270"},{"key":"e_1_3_8_44_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1751-7176.2009.00246.x"},{"key":"e_1_3_8_45_2","doi-asserted-by":"publisher","DOI":"10.3390\/biology8020030"},{"key":"e_1_3_8_46_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.freeradbiomed.2013.05.002"},{"key":"e_1_3_8_47_2","doi-asserted-by":"publisher","DOI":"10.1152\/ajpcell.00188.2017"},{"key":"e_1_3_8_48_2","doi-asserted-by":"publisher","DOI":"10.4330\/wjc.v9.i1.14"},{"key":"e_1_3_8_49_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2021.111679"},{"key":"e_1_3_8_50_2","doi-asserted-by":"publisher","DOI":"10.3390\/biom8040177"},{"key":"e_1_3_8_51_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCRESAHA.111.246140"},{"key":"e_1_3_8_52_2","doi-asserted-by":"publisher","DOI":"10.1093\/gerona\/glr092"},{"key":"e_1_3_8_53_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.exger.2019.01.022"},{"key":"e_1_3_8_54_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.freeradbiomed.2012.08.009"},{"key":"e_1_3_8_55_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00424-022-02702-x"},{"key":"e_1_3_8_56_2","doi-asserted-by":"publisher","DOI":"10.2119\/molmed.2010.00195"},{"key":"e_1_3_8_57_2","doi-asserted-by":"publisher","DOI":"10.1152\/physrev.00025.2007"},{"key":"e_1_3_8_58_2","doi-asserted-by":"publisher","DOI":"10.1093\/cvr\/cvn098"},{"key":"e_1_3_8_59_2","doi-asserted-by":"publisher","DOI":"10.1530\/JOE-12-0304"},{"key":"e_1_3_8_60_2","doi-asserted-by":"publisher","DOI":"10.1007\/s12031-012-9837-y"},{"key":"e_1_3_8_61_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.freeradbiomed.2008.09.031"},{"key":"e_1_3_8_62_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jep.2021.114835"},{"key":"e_1_3_8_63_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrcardio.2016.73"},{"key":"e_1_3_8_64_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.111.032680"}],"container-title":["Rejuvenation Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1089\/rej.2023.0061","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1089\/rej.2023.0061","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1089\/rej.2023.0061","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,2]],"date-time":"2026-05-02T01:36:07Z","timestamp":1777685767000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/full\/10.1089\/rej.2023.0061"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,4]]},"references-count":63,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2024,4]]}},"alternative-id":["10.1089\/rej.2023.0061"],"URL":"https:\/\/doi.org\/10.1089\/rej.2023.0061","relation":{},"ISSN":["1549-1684","1557-8577"],"issn-type":[{"value":"1549-1684","type":"print"},{"value":"1557-8577","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,4]]}}}