{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,21]],"date-time":"2026-08-21T13:37:58Z","timestamp":1787319478702,"version":"build-2736575974"},"reference-count":66,"publisher":"SAGE Publications","issue":"3","license":[{"start":{"date-parts":[[2024,6,1]],"date-time":"2024-06-01T00:00:00Z","timestamp":1717200000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Rejuvenation Research"],"published-print":{"date-parts":[[2024,6]]},"abstract":"<jats:p>\n                    Recently, natural herbs have gained increasing attention owing to their comparatively low toxicity levels and the abundance of historical medical documentation regarding their use. Nevertheless, owing to a lack of knowledge regarding these herbs and their compounds, attempts to find those that could be beneficial for treating diseases have often been\n                    <jats:italic toggle=\"yes\">ad hoc<\/jats:italic>\n                    ; thus, there is now a growing demand for an\n                    <jats:italic toggle=\"yes\">in silico<\/jats:italic>\n                    method to identify beneficial herbs. In this study, we present a computational approach for identifying natural herbs specifically effective in treating cognitive decline in Alzheimer's disease (AD) sufferers, which analyzes the similarities between herbal compounds and known drugs targeting AD-related proteins. Our\n                    <jats:italic toggle=\"yes\">in silico<\/jats:italic>\n                    method suggests that\n                    <jats:italic toggle=\"yes\">Corydalis ternata<\/jats:italic>\n                    can improve cognitive decline in AD sufferers. Behavioral tests with an AD mouse model for the confirmation of the\n                    <jats:italic toggle=\"yes\">in silico<\/jats:italic>\n                    prediction reveals that\n                    <jats:italic toggle=\"yes\">C. ternata<\/jats:italic>\n                    significantly alleviated the cognitive decline (memory and motor functions) caused by neurodegeneration. Further pathology analyses reveal that\n                    <jats:italic toggle=\"yes\">C. ternata<\/jats:italic>\n                    decreases the level of A\u03b2 plaques, reduces neuroinflammation, and promotes autophagy flux, and thus\n                    <jats:italic toggle=\"yes\">C. ternata<\/jats:italic>\n                    can be clinically effective for preventing mild cognitive impairment during the early stages of AD. These findings highlight the potential utility of our\n                    <jats:italic toggle=\"yes\">in silico<\/jats:italic>\n                    method and the potential clinical application of the identified natural herb in treating and preventing AD.\n                  <\/jats:p>","DOI":"10.1089\/rej.2023.0069","type":"journal-article","created":{"date-parts":[[2024,3,28]],"date-time":"2024-03-28T04:44:50Z","timestamp":1711601090000},"page":"87-101","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":2,"title":["<i>Corydalis ternata<\/i>\n                    Nakai Alleviates Cognitive Decline in Alzheimer's Disease by Reducing \u03b2-Amyloid and Neuroinflammation"],"prefix":"10.1177","volume":"27","author":[{"given":"Bomi","family":"Lee","sequence":"first","affiliation":[{"name":"Department of Bio-Integrated Science and Technology, College of Life Sciences, Sejong University, Seoul, Republic of Korea."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Myeong-Sang","family":"Yu","sequence":"additional","affiliation":[{"name":"Department of Biomedical Engineering, Chung-Ang University, Seoul, Republic of Korea."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jae Gwang","family":"Song","sequence":"additional","affiliation":[{"name":"Department of Bio-Integrated Science and Technology, College of Life Sciences, Sejong University, Seoul, Republic of Korea."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hyang-Mi","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Biomedical Engineering, Chung-Ang University, Seoul, Republic of Korea."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hyung Wook","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Bio-Integrated Science and Technology, College of Life Sciences, Sejong University, Seoul, Republic of Korea."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9107-7040","authenticated-orcid":false,"given":"Dokyun","family":"Na","sequence":"additional","affiliation":[{"name":"Department of Biomedical Engineering, Chung-Ang University, Seoul, Republic of Korea."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2024,6,14]]},"reference":[{"key":"e_1_3_5_2_2","doi-asserted-by":"publisher","DOI":"10.1111\/cts.12577"},{"key":"e_1_3_5_3_2","doi-asserted-by":"publisher","DOI":"10.1093\/bib\/bbz103"},{"key":"e_1_3_5_4_2","doi-asserted-by":"publisher","DOI":"10.3389\/fchem.2020.00612"},{"key":"e_1_3_5_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.compbiomed.2019.01.008"},{"key":"e_1_3_5_6_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41573-020-00114-z"},{"key":"e_1_3_5_7_2","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jnatprod.9b01285"},{"key":"e_1_3_5_8_2","doi-asserted-by":"publisher","DOI":"10.2174\/1570159X18666200528142429"},{"key":"e_1_3_5_9_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrdp.2015.56"},{"key":"e_1_3_5_10_2","doi-asserted-by":"publisher","DOI":"10.3390\/molecules25245789"},{"key":"e_1_3_5_11_2","doi-asserted-by":"publisher","DOI":"10.1007\/s40263-015-0287-2"},{"key":"e_1_3_5_12_2","doi-asserted-by":"publisher","DOI":"10.2174\/1386207323999201110192942"},{"key":"e_1_3_5_13_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12936-019-2724-z"},{"key":"e_1_3_5_14_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature04640"},{"key":"e_1_3_5_15_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0004489"},{"key":"e_1_3_5_16_2","doi-asserted-by":"publisher","DOI":"10.3390\/biom11040543"},{"key":"e_1_3_5_17_2","doi-asserted-by":"publisher","DOI":"10.1093\/ecam\/nel071"},{"key":"e_1_3_5_18_2","doi-asserted-by":"publisher","DOI":"10.1186\/alzrt54"},{"key":"e_1_3_5_19_2","doi-asserted-by":"publisher","DOI":"10.1186\/s13321-020-00478-9"},{"key":"e_1_3_5_20_2","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkx1037"},{"key":"e_1_3_5_21_2","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkx1076"},{"key":"e_1_3_5_22_2","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2164-14-129"},{"key":"e_1_3_5_23_2","doi-asserted-by":"publisher","DOI":"10.1021\/ci100050t"},{"key":"e_1_3_5_24_2","doi-asserted-by":"publisher","DOI":"10.1186\/s13321-018-0302-y"},{"key":"e_1_3_5_25_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.compbiomed.2021.104851"},{"key":"e_1_3_5_26_2","doi-asserted-by":"crossref","unstructured":"Yadav V Reang J Vinita et al. 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