{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T17:07:16Z","timestamp":1790960836834,"version":"4.1.0"},"reference-count":27,"publisher":"SAGE Publications","issue":"1","license":[{"start":{"date-parts":[[2024,2,1]],"date-time":"2024-02-01T00:00:00Z","timestamp":1706745600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Rejuvenation Research"],"published-print":{"date-parts":[[2024,2]]},"abstract":"<jats:p>\n                    Heart failure with reduced ejection fraction (HFrEF) is associated with reduced cardiac function and impaired quality of life. Blood flow restriction (BFR) training is emerging as a potential adjunctive therapy. This study aimed at evaluating the efficacy of combination of BFR and isometric exercises on cardiac function, functional status, and quality of life in HFrEF patients. Totally 44 patients with HFrEF were equally divided into a control group and a combined treatment group. Both groups received standard pharmacotherapy and upper limb exercise, with the combined group also undergoing BFR and isometric exercise training. We assessed demographic and clinical characteristics, New York Heart Association (NYHA) functional classification, cardiac function parameters, serum Brain Natriuretic Peptide levels, physical capacity via the 6-minute walking test, and quality of life using the Heart Failure Questionnaire (Minnesota Living with Heart Failure Questionnaire). Post-treatment, the combined group significantly improved in NYHA classification (\n                    <jats:italic toggle=\"yes\">p<\/jats:italic>\n                    \u2009=\u20090.012), with more patients shifting to a better class. Cardiac function improved in both groups, with the combined group showing a greater increase in mean left ventricular ejection fractions (\n                    <jats:italic toggle=\"yes\">p<\/jats:italic>\n                    \u2009&lt;\u20090.001), and reductions in left ventricular end-diastolic and end-systolic diameters (\n                    <jats:italic toggle=\"yes\">p<\/jats:italic>\n                    \u2009&lt;\u20090.05). The addition of BFR training to standard pharmacotherapy with upper limb exercise in HFrEF patients led to significant enhancements in cardiac function, functional status, and quality of life. These findings support the integration of BFR training into conventional HFrEF treatment regimens to maximize patient recovery outcomes.\n                  <\/jats:p>","DOI":"10.1089\/rej.2023.0070","type":"journal-article","created":{"date-parts":[[2024,2,3]],"date-time":"2024-02-03T03:03:15Z","timestamp":1706929395000},"page":"33-40","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":4,"title":["The Clinical Effects of Pharmacotherapy Combined with Blood Flow Restriction and Isometric Exercise Training in Rehabilitating Patients with Heart Failure with Reduced Ejection Fraction"],"prefix":"10.1177","volume":"27","author":[{"given":"Pinxia","family":"Wu","sequence":"first","affiliation":[{"name":"Department of Rehabilitation Medicine and Chuzhou First People's Hospital, Chuzhou, Anhui, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Division, Chuzhou First People's Hospital, Chuzhou, Anhui, China."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2024,2,15]]},"reference":[{"key":"e_1_3_4_2_2","doi-asserted-by":"publisher","DOI":"10.4065\/mcp.2009.0494"},{"key":"e_1_3_4_3_2","volume-title":"Chronic Heart Failure in Adults: Diagnosis and Management","author":"National Guideline Centre (UK)","year":"2018","unstructured":"National Guideline Centre (UK). Chronic Heart Failure in Adults: Diagnosis and Management. National Institute for Health and Care Excellence (NICE): London, UK; 2018."},{"key":"e_1_3_4_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0735-1097(02)02696-7"},{"key":"e_1_3_4_5_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.296.18.2209"},{"key":"e_1_3_4_6_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa052256"},{"key":"e_1_3_4_7_2","doi-asserted-by":"publisher","DOI":"10.1002\/ejhf.483"},{"key":"e_1_3_4_8_2","doi-asserted-by":"publisher","DOI":"10.1002\/ehf2.13498"},{"issue":"11","key":"e_1_3_4_9_2","article-title":"Exercise-based cardiac rehabilitation for coronary heart disease","volume":"11","author":"Dibben G","year":"2021","unstructured":"Dibben G, , Faulkner J, , Oldridge N, et al. Exercise-based cardiac rehabilitation for coronary heart disease. Cochrane Database Syst Rev, 2021; 11(11):CD001800.","journal-title":"Cochrane Database Syst Rev"},{"key":"e_1_3_4_10_2","doi-asserted-by":"publisher","DOI":"10.4330\/wjc.v11.i7.171"},{"issue":"6","key":"e_1_3_4_11_2","first-page":"664","article-title":"Endorsed by the Committee for Practice Guidelines of the European Society of Cardiology","volume":"21","author":"Piepoli M","year":"2014","unstructured":"Piepoli M, , Corr\u00e0 U, , Adamopoulos S, et al. Endorsed by the Committee for Practice Guidelines of the European Society of Cardiology. Secondary prevention in the clinical management of patients with cardiovascular diseases. Core components, standards and outcome measures for referral and delivery: A policy statement from the cardiac rehabilitation section of the European Association for Cardiovascular Prevention & Rehabilitation. Eur J Prev Cardiol, 2014; 21(6):664\u2013681.","journal-title":"Secondary prevention in the clinical management of patients with cardiovascular diseases. Core components, standards and outcome measures for referral and delivery: A policy statement from the cardiac rehabilitation section of the European Association for Cardiovascular Prevention & Rehabilitation. Eur J Prev Cardiol"},{"issue":"6","key":"e_1_3_4_12_2","first-page":"664","article-title":"Secondary prevention in the clinical management of patients with cardiovascular diseases","volume":"21","author":"Piepoli MF","year":"2014","unstructured":"Piepoli MF, , Corra U, , Adamopoulos S, et al. Secondary prevention in the clinical management of patients with cardiovascular diseases. Core components, standards and outcome measures for referral and delivery: A policy statement from the cardiac rehabilitation section of the European Association for Cardiovascular Prevention & Rehabilitation. Endorsed by the Committee for Practice Guidelines of the European Society of Cardiology. Eur J Prev Cardiol, 2014; 21(6):664\u2013681.","journal-title":"Core components, standards and outcome measures for referral and delivery: A policy statement from the cardiac rehabilitation section of the European Association for Cardiovascular Prevention & Rehabilitation. Endorsed by the Committee for Practice Guidelines of the European Society of Cardiology. Eur J Prev Cardiol"},{"key":"e_1_3_4_13_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1525-1594.2012.01474.x"},{"issue":"4","key":"e_1_3_4_14_2","first-page":"207","article-title":"Exercise and the heart: Risks, benefits, and recommendations for providing exercise prescriptions","volume":"3","author":"Lavie CJ","year":"2001","unstructured":"Lavie CJ, , Milani RV, , Marks P, et al. Exercise and the heart: Risks, benefits, and recommendations for providing exercise prescriptions. Ochsner J, 2001; 3(4):207\u2013213.","journal-title":"Ochsner J"},{"key":"e_1_3_4_15_2","doi-asserted-by":"publisher","DOI":"10.1097\/MD.0000000000010105"},{"key":"e_1_3_4_16_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.asmr.2021.09.025"},{"key":"e_1_3_4_17_2","doi-asserted-by":"publisher","DOI":"10.4085\/418-20"},{"key":"e_1_3_4_18_2","doi-asserted-by":"publisher","DOI":"10.1136\/bjsports-2016-097071"},{"key":"e_1_3_4_19_2","doi-asserted-by":"publisher","DOI":"10.3389\/fphys.2022.924557"},{"key":"e_1_3_4_20_2","first-page":"253","volume-title":"The criteria committee of the New York heart association","author":"Dolgin M","unstructured":"Dolgin M. The criteria committee of the New York heart association. In: Nomenclature and Criteria for Diagnosis of Diseases of the Heart and Great Vessels. (Martin D. ed.) 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