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Intraluminal monofilament model of middle cerebral artery occlusion (MCAO) was constructed in C57BL\/6J male mice, and the relative expression of substance P was detected in collected bronchoalveolar lavage fluid (BALF) and lung tissue homogenate at 24 hours, 48 hours, and 72 hours poststroke. On the other hand, different concentrations of aprepitant (0.5, 1, and 2 mg\/kg) were atomized and inhaled into MCAO mice. Inflammation cytokines and bacterial load were detected in collected BALF and lung tissue homogenate at 72-hour poststroke, and lung injury was revealed by histological examination. Aprepitant administration decreased total proteins, total cells, neutrophils, and macrophages in BALF. The concentrations of interleukin (IL)-6, IL-1\u03b2, tumor necrosis factor-\u03b1, interferon \u03b3, monocyte chemoattractant protein-1, and IL-10 in lung tissue homogenates were also diminished by the administration of aprepitant. In conclusion, aprepitant could attenuate poststroke pneumonia in mice suggesting its potential therapeutic use in the clinic.<\/jats:p>","DOI":"10.1089\/rej.2024.0011","type":"journal-article","created":{"date-parts":[[2024,4,26]],"date-time":"2024-04-26T08:05:54Z","timestamp":1714118754000},"page":"102-109","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":4,"title":["Aprepitant Alleviates Poststroke Pneumonia in a Mouse Model of Middle Cerebral Artery Occlusion"],"prefix":"10.1177","volume":"27","author":[{"given":"Zhihui","family":"Xie","sequence":"first","affiliation":[{"name":"Department of Infectious Disease, Zibo Central Hospital, Zibo, People\u2019s Republic of China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Minghui","family":"Xin","sequence":"additional","affiliation":[{"name":"Department of Clinical Laboratory, Zibo Central Hospital, Zibo, People\u2019s Republic of China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fatao","family":"Yu","sequence":"additional","affiliation":[{"name":"Department of Infectious Disease, Zibo Central Hospital, Zibo, People\u2019s Republic of China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaolin","family":"Zhu","sequence":"additional","affiliation":[{"name":"Department of Infectious Disease, Zibo Central Hospital, Zibo, People\u2019s Republic of China."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2024,6,14]]},"reference":[{"key":"e_1_3_6_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.neurol.2015.07.013"},{"key":"e_1_3_6_3_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-022-14656-2"},{"key":"e_1_3_6_4_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2022.19590"},{"key":"e_1_3_6_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(22)00309-X"},{"key":"e_1_3_6_6_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12883-022-02826-8"},{"key":"e_1_3_6_7_2","doi-asserted-by":"publisher","DOI":"10.1097\/MD.0000000000027321"},{"key":"e_1_3_6_8_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00455-019-10061-6"},{"key":"e_1_3_6_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/S2542-5196(21)00145-5"},{"issue":"11","key":"e_1_3_6_10_2","article-title":"Stroke and Pneumonia: Mechanisms, risk factors, management, and prevention","volume":"13","author":"Grossmann I","year":"2021","unstructured":"Grossmann I, , Rodriguez K, , Soni M, et al. 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