{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,10]],"date-time":"2026-10-10T02:27:25Z","timestamp":1791599245608,"version":"4.3.4"},"reference-count":57,"publisher":"SAGE Publications","issue":"6","license":[{"start":{"date-parts":[[2024,12,1]],"date-time":"2024-12-01T00:00:00Z","timestamp":1733011200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Rejuvenation Research"],"published-print":{"date-parts":[[2024,12]]},"abstract":"<jats:p>\n                    Aging-related muscle atrophy\/sarcopenia is the most common type of muscle impairment that affects the quality of life. In the current study, we examined the effect of a functional food mixture of amla, turmeric, black pepper, cinnamon, and ginger on D-galactose-induced muscle alterations in rats. Wistar rats were randomly divided into three groups: Control (C), D-galactose (G), and D-galactose + functional food mixture intervention (G + I). Rats in group-G and -G + I were injected with D-galactose (300\u2009mg\/kg\/day) for 90 days. After 3 months of the experimental period, the rats were sacrificed to collect gastrocnemius muscle. Group-G rats showed elevated levels of inflammatory cytokines (TNF\u03b1 and NF-kB), atrogenes (atrogin-1 and MuRF1), decreased insulin\/IGF1 signaling (decreased AKT phosphorylation), altered mitochondrial dynamics (increased fission and decreased fusion proteins), increased apoptotic mediators (Bax\/Bcl-2, and caspase-3), and decreased muscle cell cross-sectional area when compared with group-C (\n                    <jats:italic toggle=\"yes\">p<\/jats:italic>\n                    &lt; 0.05). Interestingly, supplementation with the functional food mixture prevented galactose-induced alterations in the muscle. The observed anti-inflammatory, insulin-sensitizing, mitochondria-protective, and antiapoptotic effects of the functional food could be the underlying mechanisms in displaying positive effects against galactose-induced muscle atrophy and, hence, may be useful for the prevention of age-related muscle disorders.\n                  <\/jats:p>","DOI":"10.1089\/rej.2024.0030","type":"journal-article","created":{"date-parts":[[2024,8,20]],"date-time":"2024-08-20T11:09:05Z","timestamp":1724152145000},"page":"181-190","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":4,"title":["Functional Food Mixture Extricates D-Galactose-Induced Skeletal Muscle Impairment in Rats"],"prefix":"10.1177","volume":"27","author":[{"given":"M.","family":"Nagaraju","sequence":"first","affiliation":[{"name":"Biochemistry Division, ICMR\u2014National Institute of Nutrition, Hyderabad, India."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pandarinath","family":"Savitikadi","sequence":"additional","affiliation":[{"name":"Biochemistry Division, ICMR\u2014National Institute of Nutrition, Hyderabad, India."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Krishna Kalyan","family":"Kalahasti","sequence":"additional","affiliation":[{"name":"Biochemistry Division, ICMR\u2014National Institute of Nutrition, Hyderabad, India."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Utkarsh R.","family":"Addi","sequence":"additional","affiliation":[{"name":"Biochemistry Division, ICMR\u2014National Institute of Nutrition, Hyderabad, India."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G. Bhanuprakash","family":"Reddy","sequence":"additional","affiliation":[{"name":"Biochemistry Division, ICMR\u2014National Institute of Nutrition, Hyderabad, India."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3777-407X","authenticated-orcid":false,"given":"S. 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