{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T22:16:44Z","timestamp":1777933004723,"version":"3.51.4"},"reference-count":56,"publisher":"SAGE Publications","issue":"1","license":[{"start":{"date-parts":[[2025,1,28]],"date-time":"2025-01-28T00:00:00Z","timestamp":1738022400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2025,1,28]],"date-time":"2025-01-28T00:00:00Z","timestamp":1738022400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Rejuvenation Research"],"published-print":{"date-parts":[[2025,2]]},"abstract":"<jats:p>\n                    Arterial stiffness is an emerging indicator of cardiovascular risk, but its causal relationship with a variety of age-related diseases is unclear. The objective is to assess the causal relationship between arterial stiffness index (ASI) and age-related diseases by Mendelian randomization (MR) analysis. We obtained instrumental variables associated with age-related diseases from genome-wide association studies (GWAS) of 484,598 European individuals, and data for ASI were obtained from the UK Biobank GWAS of 127,127 participants. We used the inverse variance-weighted as the primary analysis method. In addition, several sensitivity analyses including MR-Egger, weighted-median (WM), Mendelian randomization pleiotropy residual sum and outlier, and Cochran\u2019s Q test were performed to test the robustness of the results. Reverse MR analysis was also performed to assess reverse causal relationships between age-related diseases and ASI. We verified the causal relationship between eight age-related diseases and ASI, of which cardiovascular disease (\n                    <jats:italic toggle=\"yes\">\u03b2<\/jats:italic>\n                    = 0.19), gallbladder disease (\n                    <jats:italic toggle=\"yes\">\u03b2<\/jats:italic>\n                    = 0.85), liver, biliary, or pancreas problem (\n                    <jats:italic toggle=\"yes\">\u03b2<\/jats:italic>\n                    = 1.02), hypertension (\n                    <jats:italic toggle=\"yes\">\u03b2<\/jats:italic>\n                    = 0.19), joint disorder (\n                    <jats:italic toggle=\"yes\">\u03b2<\/jats:italic>\n                    = 0.53), and esophageal disorder (\n                    <jats:italic toggle=\"yes\">\u03b2<\/jats:italic>\n                    = 2.10) elevated ASI. In contrast, hyperthyroidism or thyrotoxicosis (\n                    <jats:italic toggle=\"yes\">\u03b2<\/jats:italic>\n                    = \u22122.17) and bowel problems (\n                    <jats:italic toggle=\"yes\">\u03b2<\/jats:italic>\n                    = \u22121.83) may reduce ASI. This MR analysis reveals causal relationships between ASI and several age-related diseases. ASI is expected to be a potential indicator of health conditions for older populations.\n                  <\/jats:p>","DOI":"10.1089\/rej.2024.0041","type":"journal-article","created":{"date-parts":[[2024,9,18]],"date-time":"2024-09-18T07:28:54Z","timestamp":1726644534000},"page":"9-16","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["Association Between Arterial Stiffness Index and Age-Related Diseases: A Mendelian Randomization Study"],"prefix":"10.1177","volume":"28","author":[{"given":"Xiaojie","family":"Yu","sequence":"first","affiliation":[{"name":"Department of Anesthesiology, Guangzhou Red Cross Hospital, Jinan University, Guangzhou, China."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yang","family":"Cao","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology, Guangzhou Red Cross Hospital, Jinan University, Guangzhou, China."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xinyi","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology, Guangzhou Red Cross Hospital, Jinan University, Guangzhou, China."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qingchun","family":"Liang","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology, The Third Affiliated Hospital, Southern Medical University, Guangzhou, China."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaodan","family":"Dong","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology, Guangzhou Red Cross Hospital, Jinan University, Guangzhou, China."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bing","family":"Liang","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology, Guangzhou Red Cross Hospital, Jinan University, Guangzhou, China."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2025,1,28]]},"reference":[{"key":"e_1_3_6_2_2","volume-title":"Global Age-Friendly Cities: A Guide","author":"World Health Organization","year":"2007","unstructured":"World Health Organization. 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