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This study aimed to assess the antidepressant and anxiolytic properties of luteolin (LTN), a potent antioxidant and anti-inflammatory component, using a 6-hydroxydopamine (6-OHDA)-induced animal model of PD. Rats were administered LTN (10, 25, and 50 mg\/kg, per oral) and fluoxetine (10 mg\/kg\/per oral) over a 28-day period. Behavioral tests were employed to estimate the depression- and anxiety-like behaviors. Rats treated with LTN exhibited significant improvement in 6-OHDA-induced mood alterations, as per behavioral tests. Additionally, LTN treatment led to increased hippocampal levels of catalase and superoxide dismutase, and a reduction in malondialdehyde. LTN downregulated the gene expression of nuclear factor kappa B (NF-\u03baB)\/nod-like receptor (NLR) pyrin domain-containing 3 (NLRP3) axis components, including NF-\u03baB, NLRP3, ASC, and Caspase1 and reduced the protein level of pro-inflammatory cytokines, including interleukin (IL)-6, interleukin (IL)-1\u03b2, and tumor necrosis factor alpha (TNF-\u03b1), in addition to augmenting the protein levels of TNF-\u03b1, IL-1\u03b2, and IL-6. Furthermore, LTN exhibited an upregulatory effect on the anti-inflammatory cytokine IL-10 within the hippocampus of 6-OHDA-induced PD rats. Also, molecular docking showed higher affinity between LTN and NF-\u03baB\/NLRP3 axis components. These findings highlight the potential anxiolytic and antidepressant impacts of LTN through its antioxidant and anti-inflammatory mechanisms against 6-OHDA-induced alterations in a rat PD model.<\/jats:p>","DOI":"10.1089\/rej.2024.0045","type":"journal-article","created":{"date-parts":[[2024,12,27]],"date-time":"2024-12-27T11:05:51Z","timestamp":1735297551000},"page":"67-82","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":16,"title":["Luteolin Exhibits Anxiolytic and Antidepressant Potential in Parkinson\u2019s Disease Rat: Antioxidant and Anti-Inflammatory Effects"],"prefix":"10.1177","volume":"28","author":[{"given":"Ruifang","family":"She","sequence":"first","affiliation":[{"name":"Department of Neurology, Jinan Central Hospital, Shandong University, Jinan City, People\u2019s Republic of China."},{"name":"Department of Neurology, The Affiliated Taian City Central Hospital of Qingdao University, Taian City, People\u2019s Republic of China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhaoting","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Neurology, The Second People\u2019s Hospital of Lianyungang City, Lianyungang City, People\u2019s Republic of China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Miaomiao","family":"Han","sequence":"additional","affiliation":[{"name":"Encephalopathy Department, Zibo Hospital of Integrated Traditional Chinese and Western Medicine, Zibo City, People\u2019s Republic of China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dapeng","family":"Zhao","sequence":"additional","affiliation":[{"name":"Department of Neurology, The Affiliated Taian City Central Hospital of Qingdao University, Taian City, People\u2019s Republic of China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiangting","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Pulmonary and Critical Care Medicine, The Affiliated Taian City Central Hospital of Qingdao University, Taian City, People\u2019s Republic of China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jian","family":"Zhou","sequence":"additional","affiliation":[{"name":"Department of Radiology, The Affiliated Taian City Central Hospital of Qingdao University, Taian City, People\u2019s Republic of China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanyan","family":"Chang","sequence":"additional","affiliation":[{"name":"Department of Neurology, The Affiliated Taian City Central Hospital of Qingdao University, Taian City, People\u2019s Republic of China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinping","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Neurology, The Affiliated Taian City Central Hospital of Qingdao University, Taian City, People\u2019s Republic of China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaohong","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Neurology, Jinan Central Hospital, Shandong University, Jinan City, People\u2019s Republic of China."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2025,3,11]]},"reference":[{"key":"e_1_3_6_2_2","doi-asserted-by":"publisher","DOI":"10.1002\/mds.28345"},{"key":"e_1_3_6_3_2","doi-asserted-by":"publisher","DOI":"10.1007\/s40801-023-00410-1"},{"key":"e_1_3_6_4_2","doi-asserted-by":"publisher","DOI":"10.1002\/acn3.246"},{"key":"e_1_3_6_5_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.95.11.6469"},{"key":"e_1_3_6_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.neubiorev.2018.10.004"},{"key":"e_1_3_6_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.parkreldis.2012.02.002"},{"key":"e_1_3_6_8_2","article-title":"Neurobiology of depression and anxiety in Parkinson\u2019s disease","volume":"2011","author":"Kano O","year":"2011","unstructured":"Kano O, , Ikeda K, , Cridebring D, et al. 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