{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,27]],"date-time":"2026-05-27T18:01:06Z","timestamp":1779904866365,"version":"3.53.1"},"reference-count":31,"publisher":"SAGE Publications","issue":"5","license":[{"start":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T00:00:00Z","timestamp":1759276800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Rejuvenation Research"],"published-print":{"date-parts":[[2025,10]]},"abstract":"<jats:p>\n                    To study the mechanism through which moxibustion alleviates inflammatory injury of synovial tissue in rheumatoid arthritis (RA) rats model by determining moxibustion\u2019s effect on ferroptosis regulation by the tumor suppressor protein p53 and solute carrier family 7 member 11 (SLC7A11). Rats were developed as RA models by the administration of Freund\u2019s complete adjuvant. In the corresponding groups, moxibustion treatment was carried out using cigarette-like moxa strips that were suspended near \u201cShenshu\u201d (BL23) and \u201cZusanli\u201d (ST36) once daily for 15 days, and the p53 agonist NSC59984 was administered intraperitoneally. After 15 days of treatment, histomorphological changes were noted by transmission electron microscopy; p53, glutathione peroxidase 4 (GPX4), and SLC7A11 expression were detected by Western blot; serum levels of reactive oxygen species (ROS), glutathione (GSH), and Fe\n                    <jats:sup>2+<\/jats:sup>\n                    were estimated with the colorimetric and fluorescent probe methods; and serum levels of tumor necrosis factor alpha (TNF-\u03b1) and interleukin 1 beta (IL-1\u03b2) were quantified by enzyme linked immunosorbent assay. Compared with the model group and agonist group, the mitochondrial damage in the moxibustion and moxibustion + agonist groups were showed varying degrees of reduction. The levels of p53, ROS, Fe\n                    <jats:sup>2+<\/jats:sup>\n                    , TNF-\u03b1, and IL-1\u03b2 in the model group were significantly higher than those in the normal group, the agonist group was significantly higher than the model group, and the moxibustion and moxibustion + agonists groups were lower than the model and agonist groups. The levels of SLC7A11, GPX4, and GSH were the opposite. Moxibustion can improve RA synovial inflammatory injury by regulating ferroptosis through inhibition of p53 protein expression.\n                  <\/jats:p>","DOI":"10.1089\/rej.2024.0110","type":"journal-article","created":{"date-parts":[[2025,4,4]],"date-time":"2025-04-04T12:27:22Z","timestamp":1743769642000},"page":"217-225","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":3,"title":["Moxibustion\u2019s Impact on Ferroptosis Regulation: A Key to Relieving Inflammatory Injury in Rheumatoid Arthritis"],"prefix":"10.1177","volume":"28","author":[{"given":"Tiancheng","family":"Wang","sequence":"first","affiliation":[{"name":"School of Integrated Traditional and Western Medicine, Anhui University of Chinese Medicine, Hefei, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0000-5020-8238","authenticated-orcid":false,"given":"Chuanyu","family":"Peng","sequence":"additional","affiliation":[{"name":"School of Acupuncture-Moxibustion and Tuina, Anhui University of Chinese Medicine, Hefei, China."},{"name":"Research Institute of Acupuncture-Moxibustion and Meridian, Anhui Academy of Chinese Medical Sciences, Hefei, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dong","family":"Gao","sequence":"additional","affiliation":[{"name":"School of Nursing, Anhui University of Chinese Medicine, Hefei, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chuanying","family":"Zhang","sequence":"additional","affiliation":[{"name":"School of Nursing, Anhui University of Chinese Medicine, Hefei, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Feng","family":"Hao","sequence":"additional","affiliation":[{"name":"School of Acupuncture-Moxibustion and Tuina, Nanjing University of Chinese Medicine, Nanjing, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lu","family":"He","sequence":"additional","affiliation":[{"name":"School of Acupuncture-Moxibustion and Tuina, Anhui University of Chinese Medicine, Hefei, China."},{"name":"Research Institute of Acupuncture-Moxibustion and Meridian, Anhui Academy of Chinese Medical Sciences, Hefei, China."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2025,10,6]]},"reference":[{"key":"e_1_3_7_2_2","first-page":"2365","article-title":"Analysis and thinking on the mechanism of moxibustion in the treatment of rheumatoid arthritis","volume":"10","author":"Xiong Y","year":"2018","unstructured":"Xiong Y, , Wu P, , Bai Y, et al. 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Chinese J Exper Traditional Med Formulae, 2022; 28:44\u201352.","journal-title":"Chinese J Exper Traditional Med Formulae"},{"key":"e_1_3_7_5_2","first-page":"677","article-title":"Effects of total glucosides of paeony on proliferation, apoptosis and inflammatory factors of synovial cells in rheumatoid arthritis","volume":"39","author":"Ma YF","year":"2022","unstructured":"Ma YF, , Han XF, , Su GL, et al. Effects of total glucosides of paeony on proliferation, apoptosis and inflammatory factors of synovial cells in rheumatoid arthritis. J Shenyang Pharmaceutical University, 2022; 39:677\u2013683.","journal-title":"J Shenyang Pharmaceutical University"},{"key":"e_1_3_7_6_2","first-page":"837","article-title":"Research prospect of ferroptosis in rheumatoid arthritis","volume":"25","author":"Ma YY","year":"2021","unstructured":"Ma YY, , Zhao YP, , Zhang J, et al. Research prospect of ferroptosis in rheumatoid arthritis. Chinese J Rheumatol, 2021; 25:837\u2013841.","journal-title":"Chinese J Rheumatol"},{"key":"e_1_3_7_7_2","first-page":"1302","article-title":"Research status of ferroptosis and lnflammatory diseases","volume":"27","author":"Li B","year":"2021","unstructured":"Li B, , Tian SY, , Guo ZJ, et al. Research status of ferroptosis and lnflammatory diseases. Med Recapitulate, 2021; 27:1302\u20131306.","journal-title":"Med Recapitulate"},{"key":"e_1_3_7_8_2","first-page":"2299","article-title":"Emerging roles of p53 in ferroptosis and its potential application","volume":"35","author":"Zhang LY","year":"2019","unstructured":"Zhang LY, , Li FR, , Wang C, et al. Emerging roles of p53 in ferroptosis and its potential application. Chinese J Pathophysiol, 2019; 35:2299\u20132304.","journal-title":"Chinese J Pathophysiol"},{"key":"e_1_3_7_9_2","first-page":"5","article-title":"The role and mechanism of long noncoding RNA MT1JP regulating p53 to inhibit inflammatory reaction of rheumatoid arthritis","volume":"6","author":"Hong HH","year":"2017","unstructured":"Hong HH, , Wang Z, , Xia Y. The role and mechanism of long noncoding RNA MT1JP regulating p53 to inhibit inflammatory reaction of rheumatoid arthritis. Rheumatism and Arthritis, 2017; 6:5\u20139.","journal-title":"Rheumatism and Arthritis"},{"key":"e_1_3_7_10_2","first-page":"303","article-title":"Clinical effects of moxibustion treatment of rheumatoid arthritis and a study of its blood IL-6, CRP levels","volume":"31","author":"Chen KH","year":"2015","unstructured":"Chen KH, , Li RB, , Li K, et al. Clinical effects of moxibustion treatment of rheumatoid arthritis and a study of its blood IL-6, CRP levels. 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