{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T22:17:04Z","timestamp":1777933024621,"version":"3.51.4"},"reference-count":22,"publisher":"SAGE Publications","issue":"7","license":[{"start":{"date-parts":[[2025,7,1]],"date-time":"2025-07-01T00:00:00Z","timestamp":1751328000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Respiratory Care"],"published-print":{"date-parts":[[2025,7]]},"abstract":"<jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>Prone positioning in mechanically ventilated patients with severe ARDS is associated with reduced mortality. COVID-19 causes variable pulmonary involvement in some patients suffering from severe respiratory failure and ARDS. Although proning in the COVID-19 patient population is increasingly common, more data are needed to fully understand its utility in those with ARDS due to COVID-19.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>We conducted a single-center retrospective study, inclusive of 100 consecutive subjects intubated for ARDS from COVID-19, admitted to the ICU from September 2020 to December 2020. Data were collected daily from time of intubation for 7\u2009d along with 30-d outcomes.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>\n                      The study included a total of 53 subjects proned and 47 nonproned during their hospitalization. Proned subjects had a mean age of 61.8\u2009years and 56.6% were male, compared with a mean age of 66.3\u2009years and 57.4% male in the nonproned group. Age, sex, other baseline characteristics, and treatments were similar between groups, except that proned subjects had a higher body mass index than nonproned subjects (34.1 \u00b1 7.5 vs 30.5 \u00b1 7.4, kg\/m\n                      <jats:sup>2<\/jats:sup>\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      = .02) and lower initial P\/F ratios (119.1 \u00b1 54.5 vs 154.0 \u00b1 92.7\u2009mm\u2009Hg,\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      = .047). Proned subjects received more neuromuscular blockade (OR 6.63, 95% CI 3.25\u201313.12,\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      &lt; .001) and higher sedation levels (two sedatives: OR = 3.00, 95% CI 1.77\u20135.08; \u22653 sedatives: OR = 7.13, 95% CI 3.96\u201312.81) with similar ICU stays, ventilator days, newly initiated renal replacement therapy, and 30-d outcomes including being alive, out of the ICU, or discharged from the hospital when compared with nonproned subjects. There were a total of 15 (28.3%) complications related to proning. Proned subjects were reintubated significantly less than the nonproned group (1.9% vs 19.1%,\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      = .006).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions:<\/jats:title>\n                    <jats:p>Proning mechanically ventilated COVID-19 subjects was associated with more frequent use of neuromuscular blockade and sedation, and lower rates of re-intubation, for respiratory failure when compared with nonproned subjects.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1089\/respcare.11259","type":"journal-article","created":{"date-parts":[[2025,3,3]],"date-time":"2025-03-03T07:23:07Z","timestamp":1740986587000},"page":"830-837","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["Outcomes of Prone Positioning in Mechanically Ventilated COVID-19 Patients"],"prefix":"10.1177","volume":"70","author":[{"given":"Jonathan K.","family":"Chandler","sequence":"first","affiliation":[{"name":"Dr. Chandler, Jandali, Joyce, Smith, and Brownback are affiliated with Division of Pulmonary Disease, Critical Care and Sleep Medicine, The University of Kansas School of Medicine, Kansas City, Kansas, USA."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Badr","family":"Jandali","sequence":"additional","affiliation":[{"name":"Dr. Chandler, Jandali, Joyce, Smith, and Brownback are affiliated with Division of Pulmonary Disease, Critical Care and Sleep Medicine, The University of Kansas School of Medicine, Kansas City, Kansas, USA."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Katie","family":"Joyce","sequence":"additional","affiliation":[{"name":"Dr. Chandler, Jandali, Joyce, Smith, and Brownback are affiliated with Division of Pulmonary Disease, Critical Care and Sleep Medicine, The University of Kansas School of Medicine, Kansas City, Kansas, USA."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dale","family":"Smith","sequence":"additional","affiliation":[{"name":"Dr. Chandler, Jandali, Joyce, Smith, and Brownback are affiliated with Division of Pulmonary Disease, Critical Care and Sleep Medicine, The University of Kansas School of Medicine, Kansas City, Kansas, USA."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lynn","family":"Chollet-Hinton","sequence":"additional","affiliation":[{"name":"Dr. Chollet-Hinton and Ratnayake are affiliated with Department of Biostatistics &amp; Data Science, The University of Kansas School of Medicine, Kansas City, Kansas, USA."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Isuru","family":"Ratnayake","sequence":"additional","affiliation":[{"name":"Dr. Chollet-Hinton and Ratnayake are affiliated with Department of Biostatistics &amp; Data Science, The University of Kansas School of Medicine, Kansas City, Kansas, USA."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kyle R.","family":"Brownback","sequence":"additional","affiliation":[{"name":"Dr. Chandler, Jandali, Joyce, Smith, and Brownback are affiliated with Division of Pulmonary Disease, Critical Care and Sleep Medicine, The University of Kansas School of Medicine, Kansas City, Kansas, USA."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2025,7,2]]},"reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1002\/path.5653"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1136\/bmj-2021-069761"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1214103"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.1513\/AnnalsATS.201704-343OT"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00134-013-3194-3"},{"key":"e_1_3_3_7_2","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.201703-0548ST"},{"key":"e_1_3_3_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.chest.2022.09.020"},{"key":"e_1_3_3_9_2","doi-asserted-by":"publisher","DOI":"10.1186\/s40001-022-00953-z"},{"key":"e_1_3_3_10_2","doi-asserted-by":"publisher","DOI":"10.1177\/0885066620980399"},{"key":"e_1_3_3_11_2","doi-asserted-by":"publisher","DOI":"10.3390\/jcm10204783"},{"key":"e_1_3_3_12_2","doi-asserted-by":"publisher","DOI":"10.1097\/CCM.0000000000004363"},{"key":"e_1_3_3_13_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2012.5669"},{"key":"e_1_3_3_14_2","doi-asserted-by":"publisher","DOI":"10.1097\/CCM.0000000000004938"},{"key":"e_1_3_3_15_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jclinane.2021.110258"},{"key":"e_1_3_3_16_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00134-020-06294-x"},{"key":"e_1_3_3_17_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00134-017-4996-5"},{"key":"e_1_3_3_18_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2016.029"},{"key":"e_1_3_3_19_2","doi-asserted-by":"publisher","DOI":"10.1186\/2110-5820-2-33"},{"key":"e_1_3_3_20_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1901686"},{"key":"e_1_3_3_21_2","doi-asserted-by":"publisher","DOI":"10.1186\/s13054-022-03983-5"},{"key":"e_1_3_3_22_2","doi-asserted-by":"publisher","unstructured":"Coronavirus Disease 2019 (COVID-19) Treatment Guidelines. 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