{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T22:16:55Z","timestamp":1777933015299,"version":"3.51.4"},"reference-count":23,"publisher":"SAGE Publications","issue":"1","license":[{"start":{"date-parts":[[2024,11,12]],"date-time":"2024-11-12T00:00:00Z","timestamp":1731369600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2024,11,12]],"date-time":"2024-11-12T00:00:00Z","timestamp":1731369600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Respiratory Care"],"published-print":{"date-parts":[[2025,1]]},"abstract":"<jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>A noninvasive ventilation (NIV) mask has been designed to deliver NIV with expiratory washout to improve efficacy of ventilation by optimizing clearance of expired gases from the anatomic dead space. This study compared the performance and comfort of a novel investigational mask with expiratory washout with a conventional mask during NIV therapy.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>In this pilot crossover study, participants with severe stable COPD attended a single visit to receive bi-level NIV through 2 masks; the investigational mask with expiratory washout and a conventional mask. The order of mask use was randomly allocated, and each mask was used for 60 min with a 30\u201360-min washout in between. The primary outcome was transcutaneous carbon dioxide at 60 min. Other physiologic and NIV device variables were also assessed.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>\n                      The mean difference (95% CI) in the transcutaneous carbon dioxide between the investigational and conventional masks at 60 min, adjusted for baseline, was \u20130.74 mm Hg, 95% CI \u20132.81 to 1.33 mm Hg (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      = .45). The investigational mask with expiratory washout elicited a lower tidal volume (\u2013128.7 mL, 95% CI \u2013190.0 to \u201367.3 mL;\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      &lt; .001) and minute ventilation (\u20132.28 L\/min,\n                      <jats:sup>,<\/jats:sup>\n                      95% CI \u20133.12 to \u20131.43 L\/min;\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      &lt; .001), and a higher leak (7.96 L\/min, 95% CI 4.39-11.54 L\/min;\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      &lt; .001) than the conventional mask. There were no differences in other physiologic responses or ratings of dyspnea or comfort.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions:<\/jats:title>\n                    <jats:p>NIV therapy delivered by using a novel mask with expiratory washout was similarly effective at reducing transcutaneous carbon dioxide, whereas the delivered tidal volume and minute ventilation were significantly lower when compared with a conventional mask in participants with severe COPD.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1089\/respcare.11876","type":"journal-article","created":{"date-parts":[[2025,1,13]],"date-time":"2025-01-13T11:57:23Z","timestamp":1736769443000},"page":"29-37","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":2,"title":["Efficacy of Noninvasive Ventilation With Expiratory Washout in Stable COPD Patients"],"prefix":"10.1177","volume":"70","author":[{"given":"Stacey","family":"Kung","sequence":"first","affiliation":[{"name":"Ms. Kung, Dr. Ruth Semprini, and Ms Eathorne are affiliated with Medical Research Institute of New Zealand, Wellington, New Zealand."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alex C.","family":"Semprini","sequence":"additional","affiliation":[{"name":"Drs. Alex Semprini, Kirton, and Beasley are affiliated with Medical Research Institute of New Zealand, Wellington, New Zealand; and Victoria University Wellington, Wellington, New Zealand."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Louis W.","family":"Kirton","sequence":"additional","affiliation":[{"name":"Drs. Alex Semprini, Kirton, and Beasley are affiliated with Medical Research Institute of New Zealand, Wellington, New Zealand; and Victoria University Wellington, Wellington, New Zealand."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jess R.","family":"Fogarin","sequence":"additional","affiliation":[{"name":"Ms. Fogarin and Mr. Zoellner are affiliated with Fisher &amp; Paykel Healthcare, Auckland, New Zealand."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sascha K.","family":"Zoellner","sequence":"additional","affiliation":[{"name":"Ms. Fogarin and Mr. Zoellner are affiliated with Fisher &amp; Paykel Healthcare, Auckland, New Zealand."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Richard","family":"Beasley","sequence":"additional","affiliation":[{"name":"Drs. Alex Semprini, Kirton, and Beasley are affiliated with Medical Research Institute of New Zealand, Wellington, New Zealand; and Victoria University Wellington, Wellington, New Zealand."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Allie","family":"Eathorne","sequence":"additional","affiliation":[{"name":"Ms. Kung, Dr. Ruth Semprini, and Ms Eathorne are affiliated with Medical Research Institute of New Zealand, Wellington, New Zealand."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ruth A.C.","family":"Semprini","sequence":"additional","affiliation":[{"name":"Ms. Kung, Dr. Ruth Semprini, and Ms Eathorne are affiliated with Medical Research Institute of New Zealand, Wellington, New Zealand."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2024,11,12]]},"reference":[{"issue":"7","key":"e_1_3_4_2_2","first-page":"CD004104","article-title":"Non-invasive ventilation for the management of acute hypercapnic respiratory failure due to exacerbation of chronic obstructive pulmonary disease","volume":"7","author":"Osadnik CR","year":"2017","unstructured":"Osadnik CR, , Tee VS, , Carson-Chahhoud KV, , Picot J, , Wedzicha JA, , Smith BJ. Non-invasive ventilation for the management of acute hypercapnic respiratory failure due to exacerbation of chronic obstructive pulmonary disease. Cochrane Database Syst Rev. 2017; 7(7):CD004104.","journal-title":"Cochrane Database Syst Rev"},{"key":"e_1_3_4_3_2","doi-asserted-by":"publisher","DOI":"10.1183\/13993003.02426-2016"},{"key":"e_1_3_4_4_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra2204556"},{"key":"e_1_3_4_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.smrv.2009.02.004"},{"key":"e_1_3_4_6_2","doi-asserted-by":"publisher","DOI":"10.1136\/thoraxjnl-2015-208209"},{"key":"e_1_3_4_7_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00134-010-2066-3"},{"key":"e_1_3_4_8_2","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.03.00039503"},{"key":"e_1_3_4_9_2","doi-asserted-by":"publisher","DOI":"10.1097\/CCM.0b013e31819b575f"},{"key":"e_1_3_4_10_2","doi-asserted-by":"publisher","DOI":"10.1152\/japplphysiol.00692.2022"},{"key":"e_1_3_4_11_2","doi-asserted-by":"publisher","DOI":"10.1152\/japplphysiol.00769.2021"},{"key":"e_1_3_4_12_2","doi-asserted-by":"publisher","DOI":"10.1183\/13993003.00239-2023"},{"key":"e_1_3_4_13_2","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.201908-1590ST"},{"key":"e_1_3_4_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0099-1767(00)90093-X"},{"key":"e_1_3_4_15_2","doi-asserted-by":"publisher","DOI":"10.1177\/0962280215588241"},{"key":"e_1_3_4_16_2","doi-asserted-by":"publisher","DOI":"10.1378\/chest.11-0485"},{"key":"e_1_3_4_17_2","doi-asserted-by":"publisher","DOI":"10.5152\/TurkThoracJ.2018.177"},{"key":"e_1_3_4_18_2","doi-asserted-by":"publisher","DOI":"10.3389\/fmed.2022.874250"},{"key":"e_1_3_4_19_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra1208707"},{"key":"e_1_3_4_20_2","doi-asserted-by":"publisher","DOI":"10.1097\/CCM.0000000000001379"},{"key":"e_1_3_4_21_2","doi-asserted-by":"publisher","DOI":"10.1186\/cc9206"},{"key":"e_1_3_4_22_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa012835"},{"key":"e_1_3_4_23_2","doi-asserted-by":"publisher","DOI":"10.1097\/CCM.0000000000005921"},{"key":"e_1_3_4_24_2","doi-asserted-by":"publisher","DOI":"10.1136\/thoraxjnl-2017-211466"}],"container-title":["Respiratory Care"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1089\/respcare.11876","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1089\/respcare.11876","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1089\/respcare.11876","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,2]],"date-time":"2026-05-02T01:36:36Z","timestamp":1777685796000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1089\/respcare.11876"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,11,12]]},"references-count":23,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2025,1]]}},"alternative-id":["10.1089\/respcare.11876"],"URL":"https:\/\/doi.org\/10.1089\/respcare.11876","relation":{},"ISSN":["1943-3654","1943-3654"],"issn-type":[{"value":"1943-3654","type":"print"},{"value":"1943-3654","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,11,12]]}}}