{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,3]],"date-time":"2026-09-03T04:53:02Z","timestamp":1788411182583,"version":"build-2803163510"},"reference-count":43,"publisher":"SAGE Publications","issue":"9","license":[{"start":{"date-parts":[[2025,4,10]],"date-time":"2025-04-10T00:00:00Z","timestamp":1744243200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Respiratory Care"],"published-print":{"date-parts":[[2025,9]]},"abstract":"<jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>We evaluated the impact of noninvasive respiratory support (NRS) and invasive mechanical ventilation duration before venovenous extracorporeal membrane oxygenation (VV-ECMO) on weaning from venovenous ECMO and survival.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>In a retrospective single-center study, we studied subjects with COVID-19 ARDS treated with VV-ECMO. The subjects were divided and analyzed according to the cut-off of NRS, invasive ventilation, and total duration of respiratory support.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>\n                      We identified a cut-off of NRS duration of 4\u2009days, invasive ventilation duration of 5\u2009days, and total respiratory support duration of 8\u2009days. Weaning from VV-ECMO was observed in 63% (15\/24) of subjects with NRS duration \u2264 4\u2009days and in 16% (4\/25) of subjects with NRS &gt; 4\u2009days (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      = .001), in 50% (17\/34) of subjects with invasive ventilation duration \u2264 5\u2009days, in 13% (2\/15) of subjects with invasive ventilation duration &gt; 5\u2009days (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      = .02), in 68% (13\/19) of subjects with total support duration &lt; 8\u2009days, and in 20% (6\/30) of subjects with total support duration &gt; 8\u2009days (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      = .001). The survival probability at 200\u2009days demonstrated a statistically significant difference in NRS and total support duration comparison (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      = .001 and\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      = .004, respectively). We did not find a statistically significant survival difference according to invasive ventilation duration (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      = .13).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions:<\/jats:title>\n                    <jats:p>In our population, the increase in NRS and total support days before ECMO could hamper weaning from VV-ECMO support. However, due to the pandemic, the small sample size, and the lack of precise data on ventilation settings, caution should be exercised in universalizing these results.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1089\/respcare.12246","type":"journal-article","created":{"date-parts":[[2025,4,10]],"date-time":"2025-04-10T04:52:01Z","timestamp":1744260721000},"page":"1140-1147","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":1,"title":["Effect of Respiratory Support Type and Total Duration on Weaning From Venovenous Extracorporeal Membrane Oxygenation in COVID-19 Patients"],"prefix":"10.1177","volume":"70","author":[{"given":"Alberto","family":"Marabotti","sequence":"first","affiliation":[{"name":"Drs. Marabotti, Cianchi, Ciapetti, Franci, Socci, Fulceri, Lazzeri, Bonizzoli, and Peris are affiliated with Intensive Care Unit and Regional ECMO Referral Centre, Azienda Ospedaliero-Universitaria Careggi, Florence, Italy."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giovanni","family":"Cianchi","sequence":"additional","affiliation":[{"name":"Drs. Marabotti, Cianchi, Ciapetti, Franci, Socci, Fulceri, Lazzeri, Bonizzoli, and Peris are affiliated with Intensive Care Unit and Regional ECMO Referral Centre, Azienda Ospedaliero-Universitaria Careggi, Florence, Italy."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Filippo","family":"Pelagatti","sequence":"additional","affiliation":[{"name":"Dr. Pelagatti is affiliated with Department of Anesthesia and Intensive Care, Careggi Hospital, University of Florence, Florence, Italy."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marco","family":"Ciapetti","sequence":"additional","affiliation":[{"name":"Drs. Marabotti, Cianchi, Ciapetti, Franci, Socci, Fulceri, Lazzeri, Bonizzoli, and Peris are affiliated with Intensive Care Unit and Regional ECMO Referral Centre, Azienda Ospedaliero-Universitaria Careggi, Florence, Italy."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrea","family":"Franci","sequence":"additional","affiliation":[{"name":"Drs. Marabotti, Cianchi, Ciapetti, Franci, Socci, Fulceri, Lazzeri, Bonizzoli, and Peris are affiliated with Intensive Care Unit and Regional ECMO Referral Centre, Azienda Ospedaliero-Universitaria Careggi, Florence, Italy."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Filippo","family":"Socci","sequence":"additional","affiliation":[{"name":"Drs. Marabotti, Cianchi, Ciapetti, Franci, Socci, Fulceri, Lazzeri, Bonizzoli, and Peris are affiliated with Intensive Care Unit and Regional ECMO Referral Centre, Azienda Ospedaliero-Universitaria Careggi, Florence, Italy."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giorgio Enzo","family":"Fulceri","sequence":"additional","affiliation":[{"name":"Drs. Marabotti, Cianchi, Ciapetti, Franci, Socci, Fulceri, Lazzeri, Bonizzoli, and Peris are affiliated with Intensive Care Unit and Regional ECMO Referral Centre, Azienda Ospedaliero-Universitaria Careggi, Florence, Italy."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chiara","family":"Lazzeri","sequence":"additional","affiliation":[{"name":"Drs. Marabotti, Cianchi, Ciapetti, Franci, Socci, Fulceri, Lazzeri, Bonizzoli, and Peris are affiliated with Intensive Care Unit and Regional ECMO Referral Centre, Azienda Ospedaliero-Universitaria Careggi, Florence, Italy."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manuela","family":"Bonizzoli","sequence":"additional","affiliation":[{"name":"Drs. Marabotti, Cianchi, Ciapetti, Franci, Socci, Fulceri, Lazzeri, Bonizzoli, and Peris are affiliated with Intensive Care Unit and Regional ECMO Referral Centre, Azienda Ospedaliero-Universitaria Careggi, Florence, Italy."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adriano","family":"Peris","sequence":"additional","affiliation":[{"name":"Drs. Marabotti, Cianchi, Ciapetti, Franci, Socci, Fulceri, Lazzeri, Bonizzoli, and Peris are affiliated with Intensive Care Unit and Regional ECMO Referral Centre, Azienda Ospedaliero-Universitaria Careggi, Florence, Italy."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2025,4,10]]},"reference":[{"key":"e_1_3_4_2_2","doi-asserted-by":"publisher","DOI":"10.1080\/17476348.2020.1804365"},{"key":"e_1_3_4_3_2","doi-asserted-by":"publisher","DOI":"10.3390\/jcm11175180"},{"key":"e_1_3_4_4_2","doi-asserted-by":"publisher","DOI":"10.1186\/s13054-021-03697-0"},{"key":"e_1_3_4_5_2","doi-asserted-by":"publisher","DOI":"10.7326\/M20-2306"},{"key":"e_1_3_4_6_2","doi-asserted-by":"publisher","DOI":"10.1186\/s40560-021-00593-1"},{"key":"e_1_3_4_7_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2020.6825"},{"key":"e_1_3_4_8_2","doi-asserted-by":"publisher","DOI":"10.1186\/s13613-020-00708-1"},{"key":"e_1_3_4_9_2","doi-asserted-by":"publisher","DOI":"10.1155\/2022\/9914081"},{"key":"e_1_3_4_10_2","doi-asserted-by":"publisher","DOI":"10.1186\/s13613-020-00692-6"},{"key":"e_1_3_4_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(09)61069-2"},{"key":"e_1_3_4_12_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1800385"},{"key":"e_1_3_4_13_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00134-020-06248-3"},{"key":"e_1_3_4_14_2","doi-asserted-by":"publisher","DOI":"10.1186\/s40560-023-00654-7"},{"key":"e_1_3_4_15_2","doi-asserted-by":"publisher","DOI":"10.1053\/j.jvca.2021.11.006"},{"key":"e_1_3_4_16_2","doi-asserted-by":"publisher","DOI":"10.1097\/MAT.0000000000001173"},{"key":"e_1_3_4_17_2","doi-asserted-by":"publisher","DOI":"10.1097\/MAT.0000000000001422"},{"key":"e_1_3_4_18_2","doi-asserted-by":"publisher","DOI":"10.1097\/MAT.0000000000001626"},{"key":"e_1_3_4_19_2","doi-asserted-by":"publisher","DOI":"10.1097\/MAT.0000000000001810"},{"key":"e_1_3_4_20_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12890-023-02605-2"},{"key":"e_1_3_4_21_2","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(1950)3:1<32::aid-cncr2820030106>3.0.co;2-3"},{"key":"e_1_3_4_22_2","doi-asserted-by":"publisher","DOI":"10.4330\/wjc.v15.i4.165"},{"key":"e_1_3_4_23_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra1208707"},{"key":"e_1_3_4_24_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM200005043421801"},{"key":"e_1_3_4_25_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMsa1410639"},{"key":"e_1_3_4_26_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00134-016-4505-2"},{"key":"e_1_3_4_27_2","doi-asserted-by":"publisher","DOI":"10.1097\/MAT.0000000000001432"},{"key":"e_1_3_4_28_2","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.201311-2023OC"},{"key":"e_1_3_4_29_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00134-013-3037-2"},{"key":"e_1_3_4_30_2","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.201606-1306OC"},{"key":"e_1_3_4_31_2","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.201604-0748CP"},{"key":"e_1_3_4_32_2","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.201303-0539OC"},{"key":"e_1_3_4_33_2","doi-asserted-by":"publisher","DOI":"10.1016\/S2213-2600(21)00414-8"},{"key":"e_1_3_4_34_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2021.4682"},{"key":"e_1_3_4_35_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2022.0028"},{"key":"e_1_3_4_36_2","unstructured":"Anonymous. 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